Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-08-22

AUTHORS

Géraldine S Maro, Matthieu Vermeren, Octavian Voiculescu, Lisa Melton, James Cohen, Patrick Charnay, Piotr Topilko

ABSTRACT

Boundary cap (BC) cells are neural crest derivatives that form clusters at the surface of the neural tube, at entry and exit points of peripheral nerve roots. Using various knock-in alleles of the mouse gene Egr2 (also known as Krox20), the expression of which, in trunk regions, is initially restricted to BC cells, we were able to trace BC cell progeny during development and analyze their fate. Trunk BC-derived cells migrated along peripheral axons and colonized spinal nerve roots and dorsal root ganglia (DRG). All Schwann cell precursors occupying the dorsal roots were derived from BC cells. In the DRG, BC-derived cells were the progenitors of both neurons, mainly nociceptive afferents, and satellite cells. These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS. More... »

PAGES

930-938

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1299

DOI

http://dx.doi.org/10.1038/nn1299

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006661347

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15322547


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