Coordinated multivesicular release at a mammalian ribbon synapse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-07-04

AUTHORS

Joshua H Singer, Luisa Lassová, Noga Vardi, Jeffrey S Diamond

ABSTRACT

Traditional models of synaptic transmission hold that release sites within an active zone operate independently. Although the release of multiple vesicles (multivesicular release; MVR) from single active zones occurs at some central synapses, MVR is not thought to require coordination among release sites. Ribbon synapses seem to be optimized to release many vesicles over an extended period, but the dynamics of MVR at ribbon synapses is unknown. We examined MVR at a ribbon synapse in a retinal slice preparation using paired recordings from presynaptic rod bipolar and postsynaptic AII amacrine cells. When evoked release was highly desynchronized, discrete postsynaptic events were larger than quantal miniature excitatory postsynaptic currents (mEPSCs) but had the same time course. The amplitude of these multiquantal mEPSCs, which seem to arise from the essentially simultaneous release of multiple vesicles, was reduced by lowering release probability. The release synchrony reflected in these multivesicular events suggests that release within an active zone is coordinated during MVR. More... »

PAGES

826-833

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1280

DOI

http://dx.doi.org/10.1038/nn1280

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014186723

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15235608


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