A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Susana Mato, Vivien Chevaleyre, David Robbe, Angel Pazos, Pablo E Castillo, Olivier J Manzoni

ABSTRACT

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors. More... »

PAGES

585-586

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1251

DOI

http://dx.doi.org/10.1038/nn1251

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042563359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15146190


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