A proportional but slower NMDA potentiation follows AMPA potentiation in LTP View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-03-28

AUTHORS

Alanna J Watt, Per Jesper Sjöström, Michael Häusser, Sacha B Nelson, Gina G Turrigiano

ABSTRACT

Most excitatory glutamatergic synapses contain both AMPA and NMDA receptors, but whether these receptors are regulated together or independently during synaptic plasticity has been controversial. Although long-term potentiation (LTP) is thought to selectively enhance AMPA currents and alter the NMDA-to-AMPA ratio, this ratio is well conserved across synapses onto the same neuron. This suggests that the NMDA-to-AMPA ratio is only transiently perturbed by LTP. To test this, we induced LTP at rat neocortical synapses and recorded mixed AMPA-NMDA currents. We observed rapid LTP of AMPA currents, as well as delayed potentiation of NMDA currents that required previous AMPA potentiation. The delayed potentiation of NMDA currents restored the original NMDA-to-AMPA ratio within 2 h of LTP induction. These data suggest that recruitment of AMPA receptors to synapses eventually induces a proportional increase in NMDA current. This may ensure that LTP does not alter the relative contributions of these two receptors to synaptic transmission and information processing. More... »

PAGES

518-524

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1220

DOI

http://dx.doi.org/10.1038/nn1220

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017737108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15048122


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