In vivo imaging of synapse formation on a growing dendritic arbor View Full Text


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Article Info

DATE

2004-02-01

AUTHORS

Cristopher M Niell, Martin P Meyer, Stephen J Smith

ABSTRACT

The form of a neuron's dendritic arbor determines the set of axons with which it may form synaptic contacts, thus establishing connectivity within neural circuits. However, the dynamic relationship between dendrite growth and synaptogenesis is not well understood. To observe both processes simultaneously, we performed long-term imaging of non-spiny dendritic arbors expressing a fluorescent postsynaptic marker protein as they arborized within the optic tectum of live zebrafish larvae. Our results indicate that almost all synapses form initially on newly extended dendritic filopodia. A fraction of these nascent synapses are maintained, which in turn stabilizes the subset of filopodia on which they form. Stabilized filopodia mature into dendritic branches, and successive iterations of this process result in growth and branching of the arbor. These findings support a 'synaptotropic model' in which synapse formation can direct dendrite arborization. More... »

PAGES

254-260

References to SciGraph publications

  • 2002-07. Transmitter-evoked local calcium release stabilizes developing dendrites in NATURE
  • 2002-10-01. Activity-dependent regulation of dendritic growth and patterning in NATURE REVIEWS NEUROSCIENCE
  • 2000-04. Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo in NATURE
  • 2000-03-01. Growth cone and dendrite dynamics in zebrafish embryos: early events in synaptogenesis imaged in vivo in NATURE NEUROSCIENCE
  • 1990. The Visual System of Fish in NONE
  • 2002-09-30. BDNF release from single cells elicits local dendritic growth in nearby neurons in NATURE NEUROSCIENCE
  • 2001-04. Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis in NATURE NEUROSCIENCE
  • 2002-07-01. Rapid recruitment of NMDA receptor transport packets to nascent synapses in NATURE NEUROSCIENCE
  • 2002-10. Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases in NATURE
  • 2002-12. Long-term dendritic spine stability in the adult cortex in NATURE
  • 2003-02-03. Translocation of CaM kinase II to synaptic sites in vivo in NATURE NEUROSCIENCE
  • 2003-10-12. Activity-induced targeting of profilin and stabilization of dendritic spine morphology in NATURE NEUROSCIENCE
  • 2003-02-18. Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline in NATURE NEUROSCIENCE
  • 2001-10-09. Visualizing synapse formation in arborizing optic axons in vivo: dynamics and modulation by BDNF in NATURE NEUROSCIENCE
  • 2001-04. How do dendrites take their shape? in NATURE NEUROSCIENCE
  • 2003-10-05. β-catenin is critical for dendritic morphogenesis in NATURE NEUROSCIENCE
  • 2001-08-27. Rapid formation and remodeling of postsynaptic densities in developing dendrites in NATURE NEUROSCIENCE
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    URI

    http://scigraph.springernature.com/pub.10.1038/nn1191

    DOI

    http://dx.doi.org/10.1038/nn1191

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021111716

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14758365


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