Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07-28

AUTHORS

Arnold J Heynen, Bong-June Yoon, Cheng-Hang Liu, Hee J Chung, Richard L Huganir, Mark F Bear

ABSTRACT

A dramatic form of experience-dependent synaptic plasticity is revealed in visual cortex when one eye is temporarily deprived of vision during early postnatal life. Monocular deprivation (MD) alters synaptic transmission such that cortical neurons cease to respond to stimulation of the deprived eye, but how this occurs is poorly understood. Here we show in rat visual cortex that brief MD sets in motion the same molecular and functional changes as the experimental model of homosynaptic long-term depression (LTD), and that prior synaptic depression by MD occludes subsequent induction of LTD. The mechanisms of LTD, about which there is now a detailed understanding, therefore contribute to visual cortical plasticity. More... »

PAGES

854-862

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1100

DOI

http://dx.doi.org/10.1038/nn1100

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015641249

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12886226


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