Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-02-10

AUTHORS

Michael D. Ehlers

ABSTRACT

Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with corresponding increases or decreases in ubiquitin conjugation of synaptic proteins and required proteasome-mediated degradation. These modifications, in turn, reciprocally altered synaptic signaling to the downstream effectors CREB (cyclic AMP response element binding protein) and ERK-MAPK (extracellular signal regulated kinase–MAP kinase). These results indicate that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses. More... »

PAGES

231-242

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1013

DOI

http://dx.doi.org/10.1038/nn1013

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002194598

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12577062


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "A Kinase Anchor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP Response Element-Binding Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine Endopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multienzyme Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteasome Endopeptidase Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, N-Methyl-D-Aspartate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptic Transmission", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehlers", 
        "givenName": "Michael D.", 
        "id": "sg:person.0644135240.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644135240.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/36103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033478989", 
          "https://doi.org/10.1038/36103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35086595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027471556", 
          "https://doi.org/10.1038/35086595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/76615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025068815", 
          "https://doi.org/10.1038/76615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050290970", 
          "https://doi.org/10.1038/nn835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35056583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031974910", 
          "https://doi.org/10.1038/35056583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004563075", 
          "https://doi.org/10.1038/nrn961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/46574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044921753", 
          "https://doi.org/10.1038/46574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042024374", 
          "https://doi.org/10.1038/88380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/83976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046226014", 
          "https://doi.org/10.1038/83976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042452005", 
          "https://doi.org/10.1038/4540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016811928", 
          "https://doi.org/10.1038/75714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/12175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013676929", 
          "https://doi.org/10.1038/12175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037622183", 
          "https://doi.org/10.1038/nn717"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-02-10", 
    "datePublishedReg": "2003-02-10", 
    "description": "Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with corresponding increases or decreases in ubiquitin conjugation of synaptic proteins and required proteasome-mediated degradation. These modifications, in turn, reciprocally altered synaptic signaling to the downstream effectors CREB (cyclic AMP response element binding protein) and ERK-MAPK (extracellular signal regulated kinase\u2013MAP kinase). These results indicate that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nn1013", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2559285", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2550006", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "ubiquitin-proteasome system", 
      "protein turnover", 
      "postsynaptic composition", 
      "postsynaptic density", 
      "experience-dependent remodeling", 
      "ubiquitin conjugation", 
      "activity-dependent remodeling", 
      "ERK MAPK", 
      "PSD proteins", 
      "global change", 
      "synaptic activity", 
      "mechanistic link", 
      "synapse formation", 
      "cultured rat hippocampal neurons", 
      "synaptic proteins", 
      "mammalian brain", 
      "rat hippocampal neurons", 
      "molecular composition", 
      "protein", 
      "hippocampal neurons", 
      "turnover", 
      "remodeling", 
      "functional reorganization", 
      "CREB", 
      "activity", 
      "activity levels", 
      "plasticity", 
      "composition", 
      "corresponding increase", 
      "multiple classes", 
      "reorganization", 
      "synaptic", 
      "degradation", 
      "synapses", 
      "neurons", 
      "modification", 
      "changes", 
      "brain", 
      "conjugation", 
      "formation", 
      "levels", 
      "turn", 
      "link", 
      "decrease", 
      "increase", 
      "class", 
      "system", 
      "density", 
      "results"
    ], 
    "name": "Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system", 
    "pagination": "231-242", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002194598"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn1013"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12577062"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn1013", 
      "https://app.dimensions.ai/details/publication/pub.1002194598"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_377.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nn1013"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn1013'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn1013'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn1013'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn1013'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      105 URIs      84 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn1013 schema:about N0e3d128e3e104a6d8cdd7d8050cde54a
2 N141c50490f444363a37463053d4b0ec9
3 N1f2d93a00bdc471fa9384a3e01b03663
4 N53b07e635e7744e19ec7806a741b1926
5 N5f67d5687f414d61bbbe64dd25fa45a5
6 N829b1ea8ce53422baf8cedd95fedfb85
7 N860a537b21c44dcc965b0eb364ea44df
8 N8fba094723df4b1a843f483114f7a871
9 N9ba7c45bf2ca423195a079c11c05d253
10 N9ffe0c0f1e024fe0a421c4df8dfa3294
11 Na7c9e0b8c5a346b9b5f0a43bdd71cb89
12 Na9db9c62961f4acdbf71209b9b47d3f4
13 Nb4936ef9ad8449fdbe5ceee1ca0b7419
14 Nb6ed067f09414b8bbd2879af0e324d64
15 Nbe46142dcbcf4f2caa1379abab6b6bc7
16 Ndb31c58967344b0b9869d2fd9f5856e6
17 Ndb4390b481de4f339571ec7c4a41f708
18 Ndb5fbd779bfd42f6bdabcb0ce0b25bbe
19 anzsrc-for:11
20 anzsrc-for:1109
21 schema:author N3a5baf905e074477bf813796e7a6e8c6
22 schema:citation sg:pub.10.1038/12175
23 sg:pub.10.1038/35056583
24 sg:pub.10.1038/35086595
25 sg:pub.10.1038/36103
26 sg:pub.10.1038/4540
27 sg:pub.10.1038/46574
28 sg:pub.10.1038/75714
29 sg:pub.10.1038/76615
30 sg:pub.10.1038/83976
31 sg:pub.10.1038/88380
32 sg:pub.10.1038/nn717
33 sg:pub.10.1038/nn835
34 sg:pub.10.1038/nrn961
35 schema:datePublished 2003-02-10
36 schema:datePublishedReg 2003-02-10
37 schema:description Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with corresponding increases or decreases in ubiquitin conjugation of synaptic proteins and required proteasome-mediated degradation. These modifications, in turn, reciprocally altered synaptic signaling to the downstream effectors CREB (cyclic AMP response element binding protein) and ERK-MAPK (extracellular signal regulated kinase–MAP kinase). These results indicate that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses.
38 schema:genre article
39 schema:isAccessibleForFree false
40 schema:isPartOf N0a39e8328add4e57a7fcbcd185dd17c9
41 Ncbed84dc9e15492b9daf3c4908d6155a
42 sg:journal.1118362
43 schema:keywords CREB
44 ERK MAPK
45 PSD proteins
46 activity
47 activity levels
48 activity-dependent remodeling
49 brain
50 changes
51 class
52 composition
53 conjugation
54 corresponding increase
55 cultured rat hippocampal neurons
56 decrease
57 degradation
58 density
59 experience-dependent remodeling
60 formation
61 functional reorganization
62 global change
63 hippocampal neurons
64 increase
65 levels
66 link
67 mammalian brain
68 mechanistic link
69 modification
70 molecular composition
71 multiple classes
72 neurons
73 plasticity
74 postsynaptic composition
75 postsynaptic density
76 protein
77 protein turnover
78 rat hippocampal neurons
79 remodeling
80 reorganization
81 results
82 synapse formation
83 synapses
84 synaptic
85 synaptic activity
86 synaptic proteins
87 system
88 turn
89 turnover
90 ubiquitin conjugation
91 ubiquitin-proteasome system
92 schema:name Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
93 schema:pagination 231-242
94 schema:productId N35bbebc2043b4633b6c6946ec127601f
95 Nb0d0d35f090e492c8a967f8e02afc05b
96 Nefe28f3f555c468dae789d4b0393c8ad
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002194598
98 https://doi.org/10.1038/nn1013
99 schema:sdDatePublished 2022-09-02T15:50
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N5f9e9db592b94bc1ac93dc6976fc638f
102 schema:url https://doi.org/10.1038/nn1013
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0a39e8328add4e57a7fcbcd185dd17c9 schema:issueNumber 3
107 rdf:type schema:PublicationIssue
108 N0e3d128e3e104a6d8cdd7d8050cde54a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cells, Cultured
110 rdf:type schema:DefinedTerm
111 N141c50490f444363a37463053d4b0ec9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Receptors, N-Methyl-D-Aspartate
113 rdf:type schema:DefinedTerm
114 N1f2d93a00bdc471fa9384a3e01b03663 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Carrier Proteins
116 rdf:type schema:DefinedTerm
117 N35bbebc2043b4633b6c6946ec127601f schema:name pubmed_id
118 schema:value 12577062
119 rdf:type schema:PropertyValue
120 N3a5baf905e074477bf813796e7a6e8c6 rdf:first sg:person.0644135240.98
121 rdf:rest rdf:nil
122 N53b07e635e7744e19ec7806a741b1926 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Proteasome Endopeptidase Complex
124 rdf:type schema:DefinedTerm
125 N5f67d5687f414d61bbbe64dd25fa45a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cysteine Endopeptidases
127 rdf:type schema:DefinedTerm
128 N5f9e9db592b94bc1ac93dc6976fc638f schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N829b1ea8ce53422baf8cedd95fedfb85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Nerve Tissue Proteins
132 rdf:type schema:DefinedTerm
133 N860a537b21c44dcc965b0eb364ea44df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Multienzyme Complexes
135 rdf:type schema:DefinedTerm
136 N8fba094723df4b1a843f483114f7a871 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Synapses
138 rdf:type schema:DefinedTerm
139 N9ba7c45bf2ca423195a079c11c05d253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name A Kinase Anchor Proteins
141 rdf:type schema:DefinedTerm
142 N9ffe0c0f1e024fe0a421c4df8dfa3294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Ubiquitin
144 rdf:type schema:DefinedTerm
145 Na7c9e0b8c5a346b9b5f0a43bdd71cb89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Animals
147 rdf:type schema:DefinedTerm
148 Na9db9c62961f4acdbf71209b9b47d3f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Synaptic Transmission
150 rdf:type schema:DefinedTerm
151 Nb0d0d35f090e492c8a967f8e02afc05b schema:name dimensions_id
152 schema:value pub.1002194598
153 rdf:type schema:PropertyValue
154 Nb4936ef9ad8449fdbe5ceee1ca0b7419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mitogen-Activated Protein Kinases
156 rdf:type schema:DefinedTerm
157 Nb6ed067f09414b8bbd2879af0e324d64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Signal Transduction
159 rdf:type schema:DefinedTerm
160 Nbe46142dcbcf4f2caa1379abab6b6bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adaptor Proteins, Signal Transducing
162 rdf:type schema:DefinedTerm
163 Ncbed84dc9e15492b9daf3c4908d6155a schema:volumeNumber 6
164 rdf:type schema:PublicationVolume
165 Ndb31c58967344b0b9869d2fd9f5856e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Cyclic AMP Response Element-Binding Protein
167 rdf:type schema:DefinedTerm
168 Ndb4390b481de4f339571ec7c4a41f708 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Hippocampus
170 rdf:type schema:DefinedTerm
171 Ndb5fbd779bfd42f6bdabcb0ce0b25bbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Rats
173 rdf:type schema:DefinedTerm
174 Nefe28f3f555c468dae789d4b0393c8ad schema:name doi
175 schema:value 10.1038/nn1013
176 rdf:type schema:PropertyValue
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
181 schema:name Neurosciences
182 rdf:type schema:DefinedTerm
183 sg:grant.2550006 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1013
184 rdf:type schema:MonetaryGrant
185 sg:grant.2559285 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1013
186 rdf:type schema:MonetaryGrant
187 sg:journal.1118362 schema:issn 1097-6256
188 1546-1726
189 schema:name Nature Neuroscience
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.0644135240.98 schema:affiliation grid-institutes:grid.26009.3d
193 schema:familyName Ehlers
194 schema:givenName Michael D.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644135240.98
196 rdf:type schema:Person
197 sg:pub.10.1038/12175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013676929
198 https://doi.org/10.1038/12175
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/35056583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031974910
201 https://doi.org/10.1038/35056583
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/35086595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027471556
204 https://doi.org/10.1038/35086595
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/36103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033478989
207 https://doi.org/10.1038/36103
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/4540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042452005
210 https://doi.org/10.1038/4540
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/46574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044921753
213 https://doi.org/10.1038/46574
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/75714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016811928
216 https://doi.org/10.1038/75714
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/76615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025068815
219 https://doi.org/10.1038/76615
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/83976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046226014
222 https://doi.org/10.1038/83976
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/88380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042024374
225 https://doi.org/10.1038/88380
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nn717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037622183
228 https://doi.org/10.1038/nn717
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nn835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050290970
231 https://doi.org/10.1038/nn835
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nrn961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004563075
234 https://doi.org/10.1038/nrn961
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.26009.3d schema:alternateName Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA
237 schema:name Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...