Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-02-10

AUTHORS

Michael D. Ehlers

ABSTRACT

Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with corresponding increases or decreases in ubiquitin conjugation of synaptic proteins and required proteasome-mediated degradation. These modifications, in turn, reciprocally altered synaptic signaling to the downstream effectors CREB (cyclic AMP response element binding protein) and ERK-MAPK (extracellular signal regulated kinase–MAP kinase). These results indicate that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses. More... »

PAGES

231-242

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1013

DOI

http://dx.doi.org/10.1038/nn1013

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002194598

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12577062


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "A Kinase Anchor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP Response Element-Binding Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine Endopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multienzyme Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteasome Endopeptidase Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, N-Methyl-D-Aspartate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptic Transmission", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehlers", 
        "givenName": "Michael D.", 
        "id": "sg:person.0644135240.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644135240.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/36103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033478989", 
          "https://doi.org/10.1038/36103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35086595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027471556", 
          "https://doi.org/10.1038/35086595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/76615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025068815", 
          "https://doi.org/10.1038/76615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050290970", 
          "https://doi.org/10.1038/nn835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35056583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031974910", 
          "https://doi.org/10.1038/35056583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004563075", 
          "https://doi.org/10.1038/nrn961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/46574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044921753", 
          "https://doi.org/10.1038/46574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/88380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042024374", 
          "https://doi.org/10.1038/88380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/83976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046226014", 
          "https://doi.org/10.1038/83976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042452005", 
          "https://doi.org/10.1038/4540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016811928", 
          "https://doi.org/10.1038/75714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/12175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013676929", 
          "https://doi.org/10.1038/12175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037622183", 
          "https://doi.org/10.1038/nn717"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-02-10", 
    "datePublishedReg": "2003-02-10", 
    "description": "Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with corresponding increases or decreases in ubiquitin conjugation of synaptic proteins and required proteasome-mediated degradation. These modifications, in turn, reciprocally altered synaptic signaling to the downstream effectors CREB (cyclic AMP response element binding protein) and ERK-MAPK (extracellular signal regulated kinase\u2013MAP kinase). These results indicate that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nn1013", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2559285", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2550006", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "ubiquitin-proteasome system", 
      "protein turnover", 
      "postsynaptic composition", 
      "postsynaptic density", 
      "experience-dependent remodeling", 
      "ubiquitin conjugation", 
      "activity-dependent remodeling", 
      "ERK MAPK", 
      "PSD proteins", 
      "global change", 
      "synaptic activity", 
      "mechanistic link", 
      "synapse formation", 
      "cultured rat hippocampal neurons", 
      "synaptic proteins", 
      "mammalian brain", 
      "rat hippocampal neurons", 
      "molecular composition", 
      "protein", 
      "hippocampal neurons", 
      "turnover", 
      "remodeling", 
      "functional reorganization", 
      "CREB", 
      "activity", 
      "activity levels", 
      "plasticity", 
      "composition", 
      "corresponding increase", 
      "multiple classes", 
      "reorganization", 
      "synaptic", 
      "degradation", 
      "synapses", 
      "neurons", 
      "modification", 
      "changes", 
      "brain", 
      "conjugation", 
      "formation", 
      "levels", 
      "turn", 
      "link", 
      "decrease", 
      "increase", 
      "class", 
      "system", 
      "density", 
      "results"
    ], 
    "name": "Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system", 
    "pagination": "231-242", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002194598"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn1013"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12577062"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn1013", 
      "https://app.dimensions.ai/details/publication/pub.1002194598"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_377.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nn1013"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn1013'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn1013'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn1013'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn1013'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      105 URIs      84 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn1013 schema:about N043c0e95d51b4eb4a56ba788e3e6d91f
2 N05cb882053d94e92a85e5eb7c2e4cf37
3 N3273aaf9e66e4e7ea5963e1675426b76
4 N38fa49d9106d48ba8a267613e7acf882
5 N4a3b04dfaeb0480aac5a3a82bf2761a9
6 N955a5e9aa6844dd4aeea5f335203343d
7 Nae17e8f6317c4803926f3ad0679b4408
8 Nb3c7d067ef864275b17c44bf6017c71a
9 Nb7a0af25413d442bb1279d0e0898cf59
10 Nbd2fc2e87475431bb7ebef95b3725e08
11 Nc767eb73d173483d9de617a5271ebf6d
12 Nc8e612051a174c62b1e7f81536177003
13 Ne1262f34e281479b921b0e844ddb9bcf
14 Nf03e6111237e4208b48988708c56eef1
15 Nf0790833efaf479fae0d95911a85aa41
16 Nf0f7156874714f5b91ec8f5b185f39d2
17 Nf21fdd843fe646ad822e6d4965d5a50f
18 Nf82f580c6c8f448da15eb53982a3b64d
19 anzsrc-for:11
20 anzsrc-for:1109
21 schema:author N6b093cb2ab77474db52efd733901c3b0
22 schema:citation sg:pub.10.1038/12175
23 sg:pub.10.1038/35056583
24 sg:pub.10.1038/35086595
25 sg:pub.10.1038/36103
26 sg:pub.10.1038/4540
27 sg:pub.10.1038/46574
28 sg:pub.10.1038/75714
29 sg:pub.10.1038/76615
30 sg:pub.10.1038/83976
31 sg:pub.10.1038/88380
32 sg:pub.10.1038/nn717
33 sg:pub.10.1038/nn835
34 sg:pub.10.1038/nrn961
35 schema:datePublished 2003-02-10
36 schema:datePublishedReg 2003-02-10
37 schema:description Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I found long-lasting, global changes in the molecular composition of the PSD dictated by synaptic activity. These changes were bidirectional, reversible, modular, and involved multiple classes of PSD proteins. Moreover, activity-dependent remodeling was accompanied by altered protein turnover, occurred with corresponding increases or decreases in ubiquitin conjugation of synaptic proteins and required proteasome-mediated degradation. These modifications, in turn, reciprocally altered synaptic signaling to the downstream effectors CREB (cyclic AMP response element binding protein) and ERK-MAPK (extracellular signal regulated kinase–MAP kinase). These results indicate that activity regulates postsynaptic composition and signaling through the ubiquitin-proteasome system, providing a mechanistic link between synaptic activity, protein turnover and the functional reorganization of synapses.
38 schema:genre article
39 schema:isAccessibleForFree false
40 schema:isPartOf N377700e069c941f88b38ad136d00ea58
41 N3e4463b4b14b4156b1768703215b4535
42 sg:journal.1118362
43 schema:keywords CREB
44 ERK MAPK
45 PSD proteins
46 activity
47 activity levels
48 activity-dependent remodeling
49 brain
50 changes
51 class
52 composition
53 conjugation
54 corresponding increase
55 cultured rat hippocampal neurons
56 decrease
57 degradation
58 density
59 experience-dependent remodeling
60 formation
61 functional reorganization
62 global change
63 hippocampal neurons
64 increase
65 levels
66 link
67 mammalian brain
68 mechanistic link
69 modification
70 molecular composition
71 multiple classes
72 neurons
73 plasticity
74 postsynaptic composition
75 postsynaptic density
76 protein
77 protein turnover
78 rat hippocampal neurons
79 remodeling
80 reorganization
81 results
82 synapse formation
83 synapses
84 synaptic
85 synaptic activity
86 synaptic proteins
87 system
88 turn
89 turnover
90 ubiquitin conjugation
91 ubiquitin-proteasome system
92 schema:name Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
93 schema:pagination 231-242
94 schema:productId N2685f69c7a6848fbbdd538e13e457a99
95 N6fe33cfad74744a1b12a4a6d132ff90c
96 Ndc69ae13fc944b0d90b0803f54365a5c
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002194598
98 https://doi.org/10.1038/nn1013
99 schema:sdDatePublished 2022-09-02T15:50
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N1393df0a9ea94d35b1a19539a9167377
102 schema:url https://doi.org/10.1038/nn1013
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N043c0e95d51b4eb4a56ba788e3e6d91f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cysteine Endopeptidases
108 rdf:type schema:DefinedTerm
109 N05cb882053d94e92a85e5eb7c2e4cf37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hippocampus
111 rdf:type schema:DefinedTerm
112 N1393df0a9ea94d35b1a19539a9167377 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N2685f69c7a6848fbbdd538e13e457a99 schema:name pubmed_id
115 schema:value 12577062
116 rdf:type schema:PropertyValue
117 N3273aaf9e66e4e7ea5963e1675426b76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Mitogen-Activated Protein Kinases
119 rdf:type schema:DefinedTerm
120 N377700e069c941f88b38ad136d00ea58 schema:issueNumber 3
121 rdf:type schema:PublicationIssue
122 N38fa49d9106d48ba8a267613e7acf882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Proteasome Endopeptidase Complex
124 rdf:type schema:DefinedTerm
125 N3e4463b4b14b4156b1768703215b4535 schema:volumeNumber 6
126 rdf:type schema:PublicationVolume
127 N4a3b04dfaeb0480aac5a3a82bf2761a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Synaptic Transmission
129 rdf:type schema:DefinedTerm
130 N6b093cb2ab77474db52efd733901c3b0 rdf:first sg:person.0644135240.98
131 rdf:rest rdf:nil
132 N6fe33cfad74744a1b12a4a6d132ff90c schema:name dimensions_id
133 schema:value pub.1002194598
134 rdf:type schema:PropertyValue
135 N955a5e9aa6844dd4aeea5f335203343d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Synapses
137 rdf:type schema:DefinedTerm
138 Nae17e8f6317c4803926f3ad0679b4408 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Nerve Tissue Proteins
140 rdf:type schema:DefinedTerm
141 Nb3c7d067ef864275b17c44bf6017c71a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Carrier Proteins
143 rdf:type schema:DefinedTerm
144 Nb7a0af25413d442bb1279d0e0898cf59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name A Kinase Anchor Proteins
146 rdf:type schema:DefinedTerm
147 Nbd2fc2e87475431bb7ebef95b3725e08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cells, Cultured
149 rdf:type schema:DefinedTerm
150 Nc767eb73d173483d9de617a5271ebf6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cyclic AMP Response Element-Binding Protein
152 rdf:type schema:DefinedTerm
153 Nc8e612051a174c62b1e7f81536177003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Signal Transduction
155 rdf:type schema:DefinedTerm
156 Ndc69ae13fc944b0d90b0803f54365a5c schema:name doi
157 schema:value 10.1038/nn1013
158 rdf:type schema:PropertyValue
159 Ne1262f34e281479b921b0e844ddb9bcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Animals
161 rdf:type schema:DefinedTerm
162 Nf03e6111237e4208b48988708c56eef1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adaptor Proteins, Signal Transducing
164 rdf:type schema:DefinedTerm
165 Nf0790833efaf479fae0d95911a85aa41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Rats
167 rdf:type schema:DefinedTerm
168 Nf0f7156874714f5b91ec8f5b185f39d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Multienzyme Complexes
170 rdf:type schema:DefinedTerm
171 Nf21fdd843fe646ad822e6d4965d5a50f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Ubiquitin
173 rdf:type schema:DefinedTerm
174 Nf82f580c6c8f448da15eb53982a3b64d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Receptors, N-Methyl-D-Aspartate
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
181 schema:name Neurosciences
182 rdf:type schema:DefinedTerm
183 sg:grant.2550006 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1013
184 rdf:type schema:MonetaryGrant
185 sg:grant.2559285 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1013
186 rdf:type schema:MonetaryGrant
187 sg:journal.1118362 schema:issn 1097-6256
188 1546-1726
189 schema:name Nature Neuroscience
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.0644135240.98 schema:affiliation grid-institutes:grid.26009.3d
193 schema:familyName Ehlers
194 schema:givenName Michael D.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644135240.98
196 rdf:type schema:Person
197 sg:pub.10.1038/12175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013676929
198 https://doi.org/10.1038/12175
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/35056583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031974910
201 https://doi.org/10.1038/35056583
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/35086595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027471556
204 https://doi.org/10.1038/35086595
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/36103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033478989
207 https://doi.org/10.1038/36103
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/4540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042452005
210 https://doi.org/10.1038/4540
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/46574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044921753
213 https://doi.org/10.1038/46574
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/75714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016811928
216 https://doi.org/10.1038/75714
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/76615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025068815
219 https://doi.org/10.1038/76615
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/83976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046226014
222 https://doi.org/10.1038/83976
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/88380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042024374
225 https://doi.org/10.1038/88380
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nn717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037622183
228 https://doi.org/10.1038/nn717
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nn835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050290970
231 https://doi.org/10.1038/nn835
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nrn961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004563075
234 https://doi.org/10.1038/nrn961
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.26009.3d schema:alternateName Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA
237 schema:name Department of Neurobiology, Box 3209, Duke University Medical Center, 27710, Durham, North Carolina, USA
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...