A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08

AUTHORS

Gao Guo, Ke Gong, Sonia Ali, Neha Ali, Shahzad Shallwani, Kimmo J Hatanpaa, Edward Pan, Bruce Mickey, Sandeep Burma, David H Wang, Santosh Kesari, Jann N Sarkaria, Dawen Zhao, Amyn A Habib

ABSTRACT

Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition has not been effective in treating this tumor. Here we propose that primary resistance to EGFR inhibition in glioma cells results from a rapid compensatory response to EGFR inhibition that mediates cell survival. We show that in glioma cells expressing either EGFR wild type or the mutant EGFRvIII, EGFR inhibition triggers a rapid adaptive response driven by increased tumor necrosis factor (TNF) secretion, which leads to activation in turn of c-Jun N-terminal kinase (JNK), the Axl receptor tyrosine kinase and extracellular signal-regulated kinases (ERK). Inhibition of this adaptive axis at multiple nodes rendered glioma cells with primary resistance sensitive to EGFR inhibition. Our findings provide a possible explanation for the failures of anti-EGFR therapy in GBM and suggest a new approach to the treatment of EGFR-expressing GBM using a combination of EGFR and TNF inhibition. More... »

PAGES

1074-1084

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.4584

DOI

http://dx.doi.org/10.1038/nn.4584

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085985609

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28604685


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Signal-Regulated MAP Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "JNK Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Gao", 
        "id": "sg:person.01313067104.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313067104.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gong", 
        "givenName": "Ke", 
        "id": "sg:person.0636762223.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636762223.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Sonia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Neha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shallwani", 
        "givenName": "Shahzad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatanpaa", 
        "givenName": "Kimmo J", 
        "id": "sg:person.01053241133.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053241133.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pan", 
        "givenName": "Edward", 
        "id": "sg:person.0741244140.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741244140.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mickey", 
        "givenName": "Bruce", 
        "id": "sg:person.01266111766.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266111766.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burma", 
        "givenName": "Sandeep", 
        "id": "sg:person.01142321463.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142321463.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA North Texas Health Care System", 
          "id": "https://www.grid.ac/institutes/grid.422201.7", 
          "name": [
            "Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.", 
            "Veterans Affairs North Texas Health Care System, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "David H", 
        "id": "sg:person.0632563206.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632563206.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Saint John's Health Center", 
          "id": "https://www.grid.ac/institutes/grid.416507.1", 
          "name": [
            "Department of Translational Neuro-Oncology and Neurotherapeutics, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kesari", 
        "givenName": "Santosh", 
        "id": "sg:person.01225062701.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225062701.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarkaria", 
        "givenName": "Jann N", 
        "id": "sg:person.0723676266.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723676266.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wake Forest University", 
          "id": "https://www.grid.ac/institutes/grid.241167.7", 
          "name": [
            "Departments of Biomedical Engineering and Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Dawen", 
        "id": "sg:person.01363422303.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363422303.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA North Texas Health Care System", 
          "id": "https://www.grid.ac/institutes/grid.422201.7", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.", 
            "Veterans Affairs North Texas Health Care System, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Habib", 
        "givenName": "Amyn A", 
        "id": "sg:person.01173330633.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173330633.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000003659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-08-0479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005240651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1241328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006262915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1241328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006262915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.7.2965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006551667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008704784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008704784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009110560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.08.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010003551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.12.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011371017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1890510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013978784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2014.02.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014545985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015457461", 
          "https://doi.org/10.1038/nn.4295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa051918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015724931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa051918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015724931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2014.448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016926114", 
          "https://doi.org/10.1038/onc.2014.448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017673370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021657597", 
          "https://doi.org/10.1038/sj.cdd.4401189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021657597", 
          "https://doi.org/10.1038/sj.cdd.4401189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023006309", 
          "https://doi.org/10.1038/nrc3918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.09230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024945449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025118294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2013.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025297721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nou348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026946190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1606508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027514498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027602247", 
          "https://doi.org/10.1038/ncomms6811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-1514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027812448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-11-0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029033130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2013.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029875727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2013.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029875727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032628685", 
          "https://doi.org/10.1038/nrc2088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033628784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035590916", 
          "https://doi.org/10.1038/onc.2013.400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035590916", 
          "https://doi.org/10.1038/onc.2013.400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-15-0989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036385614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037457908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037457908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038374700", 
          "https://doi.org/10.1038/nature10868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0705158104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040257663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.10688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041756186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1744-8069-6-64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041763134", 
          "https://doi.org/10.1186/1744-8069-6-64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042530519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-009-0067-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043638462", 
          "https://doi.org/10.1007/s11060-009-0067-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-009-0067-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043638462", 
          "https://doi.org/10.1007/s11060-009-0067-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.0612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043769312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2003.12565.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044039308", 
          "https://doi.org/10.1046/j.1523-1747.2003.12565.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.287re6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044153797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044316748", 
          "https://doi.org/10.1038/nm.3388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-12-128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047655581", 
          "https://doi.org/10.1186/1479-5876-12-128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-006-9225-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049763858", 
          "https://doi.org/10.1007/s11060-006-9225-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.02.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050986624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052112015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2014.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053077790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2014.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053077790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1142946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062456066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-16-0125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063277721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.9.focus14520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.9.focus14520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.9.focus14520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.9.focus14520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.9.focus14520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.9.focus14520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.28585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082671947", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08", 
    "datePublishedReg": "2017-08-01", 
    "description": "Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition has not been effective in treating this tumor. Here we propose that primary resistance to EGFR inhibition in glioma cells results from a rapid compensatory response to EGFR inhibition that mediates cell survival. We show that in glioma cells expressing either EGFR wild type or the mutant EGFRvIII, EGFR inhibition triggers a rapid adaptive response driven by increased tumor necrosis factor (TNF) secretion, which leads to activation in turn of c-Jun N-terminal kinase (JNK), the Axl receptor tyrosine kinase and extracellular signal-regulated kinases (ERK). Inhibition of this adaptive axis at multiple nodes rendered glioma cells with primary resistance sensitive to EGFR inhibition. Our findings provide a possible explanation for the failures of anti-EGFR therapy in GBM and suggest a new approach to the treatment of EGFR-expressing GBM using a combination of EGFR and TNF inhibition.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nn.4584", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2480880", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5503436", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5125001", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3935879", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6619804", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2562268", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3802144", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma", 
    "pagination": "1074-1084", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e70bb64048b2faaa4e617d294d296c9de63e7b070f36b01a8f498c428494345e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28604685"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9809671"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn.4584"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085985609"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn.4584", 
      "https://app.dimensions.ai/details/publication/pub.1085985609"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87117_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/neuro/journal/v20/n8/full/nn.4584.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn.4584'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn.4584'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn.4584'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn.4584'


 

This table displays all metadata directly associated to this object as RDF triples.

395 TRIPLES      21 PREDICATES      90 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn.4584 schema:about N07d2ba77d5b54840bc70fece25390aaa
2 N324d51b3e8a64f43bf092de1211f88bb
3 N474eec54d7224b1789d38a9e6459b964
4 N4a2ee0b37a754d9da8691d2903ab20cd
5 N4f1c544f85de41919ac5ad8c2bb7e1ad
6 N67f003a8d2774bd0aad1cd55ae22b0a7
7 N71e3aa7b1ccb4bb4bdbab836fba9c176
8 N84a7ebb06d6f42e1a8faedcdb8768a06
9 Nc46b2089747942668277aeb15dbc47fe
10 Ndc37e51fe1b44fb8964375c1afe9d801
11 Ne1b2ac5d31d347188ac7d873e56a6114
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N07aca692faac45f6a18faaa081ef4827
15 schema:citation sg:pub.10.1007/s11060-006-9225-y
16 sg:pub.10.1007/s11060-009-0067-2
17 sg:pub.10.1038/nature10868
18 sg:pub.10.1038/ncomms6811
19 sg:pub.10.1038/nm.3388
20 sg:pub.10.1038/nn.4295
21 sg:pub.10.1038/nrc2088
22 sg:pub.10.1038/nrc3918
23 sg:pub.10.1038/onc.2013.400
24 sg:pub.10.1038/onc.2014.448
25 sg:pub.10.1038/sj.cdd.4401189
26 sg:pub.10.1046/j.1523-1747.2003.12565.x
27 sg:pub.10.1186/1479-5876-12-128
28 sg:pub.10.1186/1744-8069-6-64
29 https://app.dimensions.ai/details/publication/pub.1082671947
30 https://doi.org/10.1016/j.ccr.2009.12.020
31 https://doi.org/10.1016/j.ccr.2013.09.004
32 https://doi.org/10.1016/j.ccr.2014.02.025
33 https://doi.org/10.1016/j.ccr.2014.05.019
34 https://doi.org/10.1016/j.cell.2012.02.053
35 https://doi.org/10.1016/j.cell.2012.12.032
36 https://doi.org/10.1016/j.celrep.2013.07.025
37 https://doi.org/10.1016/j.celrep.2015.03.012
38 https://doi.org/10.1056/nejmoa043330
39 https://doi.org/10.1056/nejmoa051918
40 https://doi.org/10.1073/pnas.0705158104
41 https://doi.org/10.1073/pnas.89.7.2965
42 https://doi.org/10.1093/neuonc/nou348
43 https://doi.org/10.1101/gad.1606508
44 https://doi.org/10.1101/gad.1890510
45 https://doi.org/10.1126/science.1142946
46 https://doi.org/10.1126/science.1241328
47 https://doi.org/10.1126/scisignal.287re6
48 https://doi.org/10.1158/0008-5472.can-05-2753
49 https://doi.org/10.1158/0008-5472.can-10-2668
50 https://doi.org/10.1158/0008-5472.can-11-1514
51 https://doi.org/10.1158/0008-5472.can-14-2004
52 https://doi.org/10.1158/0008-5472.can-15-0989
53 https://doi.org/10.1158/1078-0432.ccr-05-2510
54 https://doi.org/10.1158/1078-0432.ccr-07-0352
55 https://doi.org/10.1158/1541-7786.mcr-08-0479
56 https://doi.org/10.1158/1541-7786.mcr-16-0125
57 https://doi.org/10.1158/2159-8290.cd-11-0287
58 https://doi.org/10.1158/2159-8290.cd-12-0502
59 https://doi.org/10.1200/jco.2004.08.110
60 https://doi.org/10.1200/jco.2008.18.0612
61 https://doi.org/10.1593/neo.09230
62 https://doi.org/10.1593/neo.10688
63 https://doi.org/10.3171/2014.9.focus14520
64 https://doi.org/10.4161/cbt.28585
65 schema:datePublished 2017-08
66 schema:datePublishedReg 2017-08-01
67 schema:description Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition has not been effective in treating this tumor. Here we propose that primary resistance to EGFR inhibition in glioma cells results from a rapid compensatory response to EGFR inhibition that mediates cell survival. We show that in glioma cells expressing either EGFR wild type or the mutant EGFRvIII, EGFR inhibition triggers a rapid adaptive response driven by increased tumor necrosis factor (TNF) secretion, which leads to activation in turn of c-Jun N-terminal kinase (JNK), the Axl receptor tyrosine kinase and extracellular signal-regulated kinases (ERK). Inhibition of this adaptive axis at multiple nodes rendered glioma cells with primary resistance sensitive to EGFR inhibition. Our findings provide a possible explanation for the failures of anti-EGFR therapy in GBM and suggest a new approach to the treatment of EGFR-expressing GBM using a combination of EGFR and TNF inhibition.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N0fc7d5f505be4b24b89f4f6b4daa4213
72 N65a1eefe85dc49b387e068d34605bd57
73 sg:journal.1118362
74 schema:name A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma
75 schema:pagination 1074-1084
76 schema:productId N20ad4fabc76b4652a243a4398a37caf7
77 N3cf4731790af47c4b9f51e3f11a06351
78 N508b6bda043f4d638d5a198216eebf2c
79 Nb9df871a98be49efa0751ca7c4a16730
80 Ncb2c6d24c5c8421995558bbdcdad97a7
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085985609
82 https://doi.org/10.1038/nn.4584
83 schema:sdDatePublished 2019-04-11T12:27
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N22390c506742477c95b75897f74d8032
86 schema:url http://www.nature.com/neuro/journal/v20/n8/full/nn.4584.html
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N041c8e93570d44dfac0bf883e06aa3bd rdf:first sg:person.01225062701.28
91 rdf:rest Nafbe2974e64648238c76e052097f95ad
92 N07aca692faac45f6a18faaa081ef4827 rdf:first sg:person.01313067104.16
93 rdf:rest N8334f7d64ad140a6be1592e3105878ee
94 N07d2ba77d5b54840bc70fece25390aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Cell Line, Tumor
96 rdf:type schema:DefinedTerm
97 N0fc7d5f505be4b24b89f4f6b4daa4213 schema:issueNumber 8
98 rdf:type schema:PublicationIssue
99 N1a95a2a2bf1d4fea8ac7ec8434bdd997 rdf:first N52d1cffc9bfb44309470d413eb935e7a
100 rdf:rest N72786fd635a24289a00f1e4556d65c6c
101 N20ad4fabc76b4652a243a4398a37caf7 schema:name readcube_id
102 schema:value e70bb64048b2faaa4e617d294d296c9de63e7b070f36b01a8f498c428494345e
103 rdf:type schema:PropertyValue
104 N22390c506742477c95b75897f74d8032 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N2d3097611f6a44d490d8c9c9336e95e4 rdf:first N7035d30f8b0c4639b63ba1fe196f3983
107 rdf:rest N1a95a2a2bf1d4fea8ac7ec8434bdd997
108 N324d51b3e8a64f43bf092de1211f88bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name JNK Mitogen-Activated Protein Kinases
110 rdf:type schema:DefinedTerm
111 N3cf4731790af47c4b9f51e3f11a06351 schema:name doi
112 schema:value 10.1038/nn.4584
113 rdf:type schema:PropertyValue
114 N3e8fa197308c4d848baf0f1b8dabde2c rdf:first sg:person.01053241133.39
115 rdf:rest N89b69d62a95645e1bf51be02593d9c8a
116 N41a942f450404925be14481143e0b6d8 rdf:first sg:person.0632563206.13
117 rdf:rest N041c8e93570d44dfac0bf883e06aa3bd
118 N474eec54d7224b1789d38a9e6459b964 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antineoplastic Agents
120 rdf:type schema:DefinedTerm
121 N4a2ee0b37a754d9da8691d2903ab20cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 N4f1c544f85de41919ac5ad8c2bb7e1ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cell Survival
126 rdf:type schema:DefinedTerm
127 N508b6bda043f4d638d5a198216eebf2c schema:name pubmed_id
128 schema:value 28604685
129 rdf:type schema:PropertyValue
130 N52d1cffc9bfb44309470d413eb935e7a schema:affiliation https://www.grid.ac/institutes/grid.267313.2
131 schema:familyName Ali
132 schema:givenName Neha
133 rdf:type schema:Person
134 N65a1eefe85dc49b387e068d34605bd57 schema:volumeNumber 20
135 rdf:type schema:PublicationVolume
136 N67f003a8d2774bd0aad1cd55ae22b0a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cell Proliferation
138 rdf:type schema:DefinedTerm
139 N7035d30f8b0c4639b63ba1fe196f3983 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
140 schema:familyName Ali
141 schema:givenName Sonia
142 rdf:type schema:Person
143 N71e3aa7b1ccb4bb4bdbab836fba9c176 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name ErbB Receptors
145 rdf:type schema:DefinedTerm
146 N72786fd635a24289a00f1e4556d65c6c rdf:first Ndb6c8cc7e2ae471cb4d01f350c10d82f
147 rdf:rest N3e8fa197308c4d848baf0f1b8dabde2c
148 N8334f7d64ad140a6be1592e3105878ee rdf:first sg:person.0636762223.51
149 rdf:rest N2d3097611f6a44d490d8c9c9336e95e4
150 N84a7ebb06d6f42e1a8faedcdb8768a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Signal Transduction
152 rdf:type schema:DefinedTerm
153 N873db9ff8761477789239f4586154b50 rdf:first sg:person.01363422303.95
154 rdf:rest N939efdb3d7054a21a25e02e44cb1389a
155 N89b69d62a95645e1bf51be02593d9c8a rdf:first sg:person.0741244140.25
156 rdf:rest Nc2cedd11e16a495fb77c108a74572cf9
157 N939efdb3d7054a21a25e02e44cb1389a rdf:first sg:person.01173330633.42
158 rdf:rest rdf:nil
159 Nafbe2974e64648238c76e052097f95ad rdf:first sg:person.0723676266.73
160 rdf:rest N873db9ff8761477789239f4586154b50
161 Nb954bc7ef47646c1933fa10be1801e33 rdf:first sg:person.01142321463.18
162 rdf:rest N41a942f450404925be14481143e0b6d8
163 Nb9df871a98be49efa0751ca7c4a16730 schema:name nlm_unique_id
164 schema:value 9809671
165 rdf:type schema:PropertyValue
166 Nc2cedd11e16a495fb77c108a74572cf9 rdf:first sg:person.01266111766.56
167 rdf:rest Nb954bc7ef47646c1933fa10be1801e33
168 Nc46b2089747942668277aeb15dbc47fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Extracellular Signal-Regulated MAP Kinases
170 rdf:type schema:DefinedTerm
171 Ncb2c6d24c5c8421995558bbdcdad97a7 schema:name dimensions_id
172 schema:value pub.1085985609
173 rdf:type schema:PropertyValue
174 Ndb6c8cc7e2ae471cb4d01f350c10d82f schema:affiliation https://www.grid.ac/institutes/grid.267313.2
175 schema:familyName Shallwani
176 schema:givenName Shahzad
177 rdf:type schema:Person
178 Ndc37e51fe1b44fb8964375c1afe9d801 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Brain Neoplasms
180 rdf:type schema:DefinedTerm
181 Ne1b2ac5d31d347188ac7d873e56a6114 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Glioblastoma
183 rdf:type schema:DefinedTerm
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
188 schema:name Oncology and Carcinogenesis
189 rdf:type schema:DefinedTerm
190 sg:grant.2480880 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
191 rdf:type schema:MonetaryGrant
192 sg:grant.2562268 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
193 rdf:type schema:MonetaryGrant
194 sg:grant.3802144 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
195 rdf:type schema:MonetaryGrant
196 sg:grant.3935879 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
197 rdf:type schema:MonetaryGrant
198 sg:grant.5125001 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
199 rdf:type schema:MonetaryGrant
200 sg:grant.5503436 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
201 rdf:type schema:MonetaryGrant
202 sg:grant.6619804 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.4584
203 rdf:type schema:MonetaryGrant
204 sg:journal.1118362 schema:issn 1097-6256
205 1546-1726
206 schema:name Nature Neuroscience
207 rdf:type schema:Periodical
208 sg:person.01053241133.39 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
209 schema:familyName Hatanpaa
210 schema:givenName Kimmo J
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053241133.39
212 rdf:type schema:Person
213 sg:person.01142321463.18 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
214 schema:familyName Burma
215 schema:givenName Sandeep
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142321463.18
217 rdf:type schema:Person
218 sg:person.01173330633.42 schema:affiliation https://www.grid.ac/institutes/grid.422201.7
219 schema:familyName Habib
220 schema:givenName Amyn A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173330633.42
222 rdf:type schema:Person
223 sg:person.01225062701.28 schema:affiliation https://www.grid.ac/institutes/grid.416507.1
224 schema:familyName Kesari
225 schema:givenName Santosh
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225062701.28
227 rdf:type schema:Person
228 sg:person.01266111766.56 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
229 schema:familyName Mickey
230 schema:givenName Bruce
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266111766.56
232 rdf:type schema:Person
233 sg:person.01313067104.16 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
234 schema:familyName Guo
235 schema:givenName Gao
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313067104.16
237 rdf:type schema:Person
238 sg:person.01363422303.95 schema:affiliation https://www.grid.ac/institutes/grid.241167.7
239 schema:familyName Zhao
240 schema:givenName Dawen
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363422303.95
242 rdf:type schema:Person
243 sg:person.0632563206.13 schema:affiliation https://www.grid.ac/institutes/grid.422201.7
244 schema:familyName Wang
245 schema:givenName David H
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632563206.13
247 rdf:type schema:Person
248 sg:person.0636762223.51 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
249 schema:familyName Gong
250 schema:givenName Ke
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636762223.51
252 rdf:type schema:Person
253 sg:person.0723676266.73 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
254 schema:familyName Sarkaria
255 schema:givenName Jann N
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723676266.73
257 rdf:type schema:Person
258 sg:person.0741244140.25 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
259 schema:familyName Pan
260 schema:givenName Edward
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741244140.25
262 rdf:type schema:Person
263 sg:pub.10.1007/s11060-006-9225-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1049763858
264 https://doi.org/10.1007/s11060-006-9225-y
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s11060-009-0067-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043638462
267 https://doi.org/10.1007/s11060-009-0067-2
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nature10868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038374700
270 https://doi.org/10.1038/nature10868
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/ncomms6811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027602247
273 https://doi.org/10.1038/ncomms6811
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nm.3388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044316748
276 https://doi.org/10.1038/nm.3388
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nn.4295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015457461
279 https://doi.org/10.1038/nn.4295
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/nrc2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032628685
282 https://doi.org/10.1038/nrc2088
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nrc3918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023006309
285 https://doi.org/10.1038/nrc3918
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/onc.2013.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035590916
288 https://doi.org/10.1038/onc.2013.400
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/onc.2014.448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016926114
291 https://doi.org/10.1038/onc.2014.448
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/sj.cdd.4401189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021657597
294 https://doi.org/10.1038/sj.cdd.4401189
295 rdf:type schema:CreativeWork
296 sg:pub.10.1046/j.1523-1747.2003.12565.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044039308
297 https://doi.org/10.1046/j.1523-1747.2003.12565.x
298 rdf:type schema:CreativeWork
299 sg:pub.10.1186/1479-5876-12-128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047655581
300 https://doi.org/10.1186/1479-5876-12-128
301 rdf:type schema:CreativeWork
302 sg:pub.10.1186/1744-8069-6-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041763134
303 https://doi.org/10.1186/1744-8069-6-64
304 rdf:type schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1082671947 schema:CreativeWork
306 https://doi.org/10.1016/j.ccr.2009.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009110560
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ccr.2013.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025297721
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ccr.2014.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014545985
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.ccr.2014.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053077790
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.cell.2012.02.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050986624
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.cell.2012.12.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011371017
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.celrep.2013.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029875727
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.celrep.2015.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037457908
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1056/nejmoa051918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015724931
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.0705158104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040257663
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.89.7.2965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006551667
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/neuonc/nou348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026946190
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1101/gad.1606508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027514498
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1101/gad.1890510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013978784
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1126/science.1142946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456066
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1126/science.1241328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006262915
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1126/scisignal.287re6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044153797
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1158/0008-5472.can-05-2753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025118294
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1158/0008-5472.can-10-2668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008704784
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1158/0008-5472.can-11-1514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027812448
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1158/0008-5472.can-14-2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000003659
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1158/0008-5472.can-15-0989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036385614
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1158/1078-0432.ccr-05-2510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033628784
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1158/1078-0432.ccr-07-0352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042530519
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1158/1541-7786.mcr-08-0479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005240651
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1158/1541-7786.mcr-16-0125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063277721
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1158/2159-8290.cd-11-0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029033130
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1158/2159-8290.cd-12-0502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017673370
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.2004.08.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010003551
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1200/jco.2008.18.0612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043769312
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1593/neo.09230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024945449
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1593/neo.10688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041756186
371 rdf:type schema:CreativeWork
372 https://doi.org/10.3171/2014.9.focus14520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071080689
373 rdf:type schema:CreativeWork
374 https://doi.org/10.4161/cbt.28585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293116
375 rdf:type schema:CreativeWork
376 https://www.grid.ac/institutes/grid.241167.7 schema:alternateName Wake Forest University
377 schema:name Departments of Biomedical Engineering and Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
380 schema:name Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
381 Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
382 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
383 Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.416507.1 schema:alternateName Saint John's Health Center
386 schema:name Department of Translational Neuro-Oncology and Neurotherapeutics, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California, USA.
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.422201.7 schema:alternateName VA North Texas Health Care System
389 schema:name Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
390 Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
391 Veterans Affairs North Texas Health Care System, Dallas, Texas, USA.
392 rdf:type schema:Organization
393 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
394 schema:name Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
395 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...