Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02

AUTHORS

Roman A Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz, Raju Tomer, Alán Alpár, Jan Mulder, Frédéric Clotman, Erik Keimpema, Brian Hsueh, Ailey K Crow, Henrik Martens, Christian Schwindling, Daniela Calvigioni, Jaideep S Bains, Zoltán Máté, Gábor Szabó, Yuchio Yanagawa, Ming-Dong Zhang, Andre Rendeiro, Matthias Farlik, Mathias Uhlén, Peer Wulff, Christoph Bock, Christian Broberger, Karl Deisseroth, Tomas Hökfelt, Sten Linnarsson, Tamas L Horvath, Tibor Harkany

ABSTRACT

The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S+ neurons of the suprachiasmatic nucleus. These neuroendocrine dopamine cells may contribute to the dopaminergic inhibition of prolactin secretion diurnally, as their neuromedin S+ inputs originate from neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian fashion. Overall, our catalog of neuronal subclasses provides new understanding of hypothalamic organization and function. More... »

PAGES

176-188

References to SciGraph publications

  • 2014-07. Advanced CLARITY for rapid and high-resolution imaging of intact tissues in NATURE PROTOCOLS
  • 1990-05. Peptides and transmitter enzymes in hypothalamic magnocellular neurons after administration of hyperosmotic stimuli: comparison between messenger RNA and peptide/protein levels in CELL AND TISSUE RESEARCH
  • 2016-02. Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes in NATURE BIOTECHNOLOGY
  • 2009-08. Myelin Proteomics: Molecular Anatomy of an Insulating Sheath in MOLECULAR NEUROBIOLOGY
  • 1998-10. Leptin and the regulation of body weight in mammals in NATURE
  • 2015-09. A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion in NATURE
  • 2008-07. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex in NATURE REVIEWS NEUROSCIENCE
  • 2014-02. Quantitative single-cell RNA-seq with unique molecular identifiers in NATURE METHODS
  • 2011-05. Global quantification of mammalian gene expression control in NATURE
  • 2014-02-02. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger in NATURE
  • 2016-03. Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis in NATURE METHODS
  • 2016-02. Adult mouse cortical cell taxonomy revealed by single cell transcriptomics in NATURE NEUROSCIENCE
  • 2013-05. Spatiotemporal expression pattern of DsRedT3/CCK gene construct during postnatal development of myenteric plexus in transgenic mice in CELL AND TISSUE RESEARCH
  • 2014-12. Complex molecular regulation of tyrosine hydroxylase in JOURNAL OF NEURAL TRANSMISSION
  • 2011-03. Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nn.4462

    DOI

    http://dx.doi.org/10.1038/nn.4462

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020765465

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27991900


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