Piezo2 is the principal mechanotransduction channel for proprioception View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-09

AUTHORS

Seung-Hyun Woo, Viktor Lukacs, Joriene C de Nooij, Dasha Zaytseva, Connor R Criddle, Allain Francisco, Thomas M Jessell, Katherine A Wilkinson, Ardem Patapoutian

ABSTRACT

Proprioception, the perception of body and limb position, is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the stretch and tension experienced by muscles, tendons, skin and joints. In mammals, the molecular identity of the stretch-sensitive channel that mediates proprioception is unknown. We found that the mechanically activated nonselective cation channel Piezo2 was expressed in sensory endings of proprioceptors innervating muscle spindles and Golgi tendon organs in mice. Two independent mouse lines that lack Piezo2 in proprioceptive neurons showed severely uncoordinated body movements and abnormal limb positions. Moreover, the mechanosensitivity of parvalbumin-expressing neurons that predominantly mark proprioceptors was dependent on Piezo2 expression in vitro, and the stretch-induced firing of proprioceptors in muscle-nerve recordings was markedly reduced in Piezo2-deficient mice. Together, our results indicate that Piezo2 is the major mechanotransducer of mammalian proprioceptors. More... »

PAGES

1756-1762

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.4162

DOI

http://dx.doi.org/10.1038/nn.4162

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036465760

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26551544


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