Genome-wide identification and characterization of functional neuronal activity–dependent enhancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

Athar N Malik, Thomas Vierbuchen, Martin Hemberg, Alex A Rubin, Emi Ling, Cameron H Couch, Hume Stroud, Ivo Spiegel, Kyle Kai-How Farh, David A Harmin, Michael E Greenberg

ABSTRACT

Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function across the genome to mediate activity-dependent transcription in mouse cortical neurons. We find that the subset of enhancers enriched for monomethylation of histone H3 Lys4 (H3K4me1) and binding of the transcriptional coactivator CREBBP (also called CBP) that shows increased acetylation of histone H3 Lys27 (H3K27ac) after membrane depolarization of cortical neurons functions to regulate activity-dependent transcription. A subset of these enhancers appears to require binding of FOS, which was previously thought to bind primarily to promoters. These findings suggest that FOS functions at enhancers to control activity-dependent gene programs that are critical for nervous system function and provide a resource of functional cis-regulatory elements that may give insight into the genetic variants that contribute to brain development and disease. More... »

PAGES

1330-1339

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.3808

DOI

http://dx.doi.org/10.1038/nn.3808

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039681422

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25195102


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