LKB1 and AMPK regulate synaptic remodeling in old age View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-03

AUTHORS

Melanie A Samuel, P Emanuela Voinescu, Brendan N Lilley, Rafa de Cabo, Marc Foretz, Benoit Viollet, Basil Pawlyk, Michael A Sandberg, Demetrios G Vavvas, Joshua R Sanes

ABSTRACT

In this study, the authors show that age-related aberrant synaptic remodeling in the retinal outer plexiform layer is mediated by LBK1-AMPK signaling. They also show that treatments which elevate AMPK signaling, including caloric restriction or administration of metformin, can ameliorate these deficits.

PAGES

1190-1197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.3772

DOI

http://dx.doi.org/10.1038/nn.3772

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010704591

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25086610


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