A Spinal Analogue of Memory Reconsolidation Enables Reversal of Hyperalgesia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-07-06

AUTHORS

Robert P. Bonin, Yves De Koninck

ABSTRACT

Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system. More... »

PAGES

1043-1045

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.3758

DOI

http://dx.doi.org/10.1038/nn.3758

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029642222

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24997764


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