Tau promotes neurodegeneration through global chromatin relaxation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

Bess Frost, Martin Hemberg, Jada Lewis, Mel B Feany

ABSTRACT

The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer's disease. Previous studies have linked oxidative stress and subsequent DNA damage to neuronal death in Alzheimer's disease and related tauopathies. Given that DNA damage can substantially alter chromatin structure, we examined epigenetic changes in tau-induced neurodegeneration. We found widespread loss of heterochromatin in tau transgenic Drosophila and mice and in human Alzheimer's disease. Notably, genetic rescue of tau-induced heterochromatin loss substantially reduced neurodegeneration in Drosophila. We identified oxidative stress and subsequent DNA damage as a mechanistic link between transgenic tau expression and heterochromatin relaxation, and found that heterochromatin loss permitted aberrant gene expression in tauopathies. Furthermore, large-scale analyses from the brains of individuals with Alzheimer's disease revealed a widespread transcriptional increase in genes that were heterochromatically silenced in controls. Our results establish heterochromatin loss as a toxic effector of tau-induced neurodegeneration and identify chromatin structure as a potential therapeutic target in Alzheimer's disease. More... »

PAGES

357-366

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.3639

DOI

http://dx.doi.org/10.1038/nn.3639

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022076812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24464041


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterochromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Degeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tauopathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "tau Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frost", 
        "givenName": "Bess", 
        "id": "sg:person.01262325312.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262325312.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Department of Ophthalmology and Program in Neurobiology, Boston Children's Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hemberg", 
        "givenName": "Martin", 
        "id": "sg:person.0777452173.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777452173.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida", 
          "id": "https://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewis", 
        "givenName": "Jada", 
        "id": "sg:person.01166043302.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166043302.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feany", 
        "givenName": "Mel B", 
        "id": "sg:person.01171055310.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171055310.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrn2967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000024338", 
          "https://doi.org/10.1038/nrn2967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001245785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001428427", 
          "https://doi.org/10.1038/nn1774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001506500", 
          "https://doi.org/10.1038/nature04916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001506500", 
          "https://doi.org/10.1038/nature04916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001506500", 
          "https://doi.org/10.1038/nature04916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2010.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002766973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003714959", 
          "https://doi.org/10.1038/nmeth.1906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2005.12.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003730529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci28769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004657509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0308512100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007985703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906811106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008649415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.01.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008754622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010823915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(04)00017-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011095495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/78078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013225417", 
          "https://doi.org/10.1038/78078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/78078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013225417", 
          "https://doi.org/10.1038/78078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013385393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e07-04-0327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015074057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms12095461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015074823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016020461", 
          "https://doi.org/10.1038/nature01126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016020461", 
          "https://doi.org/10.1038/nature01126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2010.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017331469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a011585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017885288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-genet-110410-132541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017940960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0002600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019117739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021556015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.229102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022792016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0024134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024460279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026324467", 
          "https://doi.org/10.1038/ng1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026324467", 
          "https://doi.org/10.1038/ng1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90216-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026628495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027602190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029225241", 
          "https://doi.org/10.1038/nature04917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029225241", 
          "https://doi.org/10.1038/nature04917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029225241", 
          "https://doi.org/10.1038/nature04917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-4580(90)90542-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029525712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-4580(90)90542-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029525712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029769991", 
          "https://doi.org/10.1038/nrn2985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410430617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030056826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030094308", 
          "https://doi.org/10.1038/ncb1528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030094308", 
          "https://doi.org/10.1038/ncb1528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318669", 
          "https://doi.org/10.1038/31508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318669", 
          "https://doi.org/10.1038/31508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030549218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2012.06.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031159843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111692200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032061155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032994501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035645372", 
          "https://doi.org/10.1038/nm1784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036070274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddm011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036516030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2012.156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037111415", 
          "https://doi.org/10.1038/nrneurol.2012.156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65721-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037136929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2006.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038551375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1062382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039022937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biolcel.2004.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040582651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/459927a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043448162", 
          "https://doi.org/10.1038/459927a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/459927a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043448162", 
          "https://doi.org/10.1038/459927a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808759200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043864473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044654423", 
          "https://doi.org/10.1038/nsmb.1644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044654423", 
          "https://doi.org/10.1038/nsmb.1644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.24.1.1121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045688590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046161035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2202-9-42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048107887", 
          "https://doi.org/10.1186/1471-2202-9-42"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1010-1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048301228", 
          "https://doi.org/10.1038/nbt1010-1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2011.00778.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048392547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2009-10-3-r25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583368", 
          "https://doi.org/10.1186/gb-2009-10-3-r25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.02.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050800227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.12.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052695631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/5.10.1277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059452691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083259853", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.18-20-08126.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083326123"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-03", 
    "datePublishedReg": "2014-03-01", 
    "description": "The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer's disease. Previous studies have linked oxidative stress and subsequent DNA damage to neuronal death in Alzheimer's disease and related tauopathies. Given that DNA damage can substantially alter chromatin structure, we examined epigenetic changes in tau-induced neurodegeneration. We found widespread loss of heterochromatin in tau transgenic Drosophila and mice and in human Alzheimer's disease. Notably, genetic rescue of tau-induced heterochromatin loss substantially reduced neurodegeneration in Drosophila. We identified oxidative stress and subsequent DNA damage as a mechanistic link between transgenic tau expression and heterochromatin relaxation, and found that heterochromatin loss permitted aberrant gene expression in tauopathies. Furthermore, large-scale analyses from the brains of individuals with Alzheimer's disease revealed a widespread transcriptional increase in genes that were heterochromatically silenced in controls. Our results establish heterochromatin loss as a toxic effector of tau-induced neurodegeneration and identify chromatin structure as a potential therapeutic target in Alzheimer's disease. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nn.3639", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2449081", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3109462", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439252", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696450", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2448533", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2617826", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2369323", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2520074", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Tau promotes neurodegeneration through global chromatin relaxation", 
    "pagination": "357-366", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "692dc00c67fe8adfea668e5b86714d926f71b5c7520d5e6cc23f8bb33e3666fe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24464041"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9809671"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn.3639"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022076812"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn.3639", 
      "https://app.dimensions.ai/details/publication/pub.1022076812"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/neuro/journal/v17/n3/full/nn.3639.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn.3639'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn.3639'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn.3639'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn.3639'


 

This table displays all metadata directly associated to this object as RDF triples.

378 TRIPLES      21 PREDICATES      106 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn.3639 schema:about N022a6815f8394677a8ba8b8ed35a5274
2 N0902b6bcb8d94f60880dfc731bc93640
3 N1bf65ac645574d6c87b13f8eb440639d
4 N1cf2d46b105744c0abe368f508cb23e8
5 N34008842498e4215a69ec62c945721b5
6 N3c397342b1b346b7adf3b54c77e2fe17
7 N6b85f3d7880d437494315b01dc9727e9
8 N96b10c95133e4916a9796eff5a422f37
9 Na5b8d4b500e84760b66fbbb524e52535
10 Na74fd5b0fd664a629aa36cde927849d7
11 Nc49ada0f870443b5ad965a6ca3e6139a
12 Ncc12764fdf6346f5ad5d0c9502e2d1ad
13 Nccc52081b0794def8b7823621f0a4191
14 Ne94f1f9cdf934a37963372ff54705adc
15 Nee970f5114c141c98ee41c8b3ea8084c
16 Nf038ad8a60b3499da1adacf7416cbf7f
17 Nfa363eba1fc84bf98c213fb262a729d7
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author N55c5afa5943a49919132fa8ed86a1930
21 schema:citation sg:pub.10.1038/31508
22 sg:pub.10.1038/459927a
23 sg:pub.10.1038/78078
24 sg:pub.10.1038/nature01126
25 sg:pub.10.1038/nature04916
26 sg:pub.10.1038/nature04917
27 sg:pub.10.1038/nbt1010-1045
28 sg:pub.10.1038/ncb1528
29 sg:pub.10.1038/ng1817
30 sg:pub.10.1038/nm1784
31 sg:pub.10.1038/nmeth.1906
32 sg:pub.10.1038/nn1774
33 sg:pub.10.1038/nrn2967
34 sg:pub.10.1038/nrn2985
35 sg:pub.10.1038/nrneurol.2012.156
36 sg:pub.10.1038/nsmb.1644
37 sg:pub.10.1186/1471-2202-9-42
38 sg:pub.10.1186/gb-2009-10-3-r25
39 https://app.dimensions.ai/details/publication/pub.1083259853
40 https://doi.org/10.1002/ana.410430617
41 https://doi.org/10.1016/0092-8674(95)90216-3
42 https://doi.org/10.1016/0197-4580(90)90542-8
43 https://doi.org/10.1016/j.biolcel.2004.06.003
44 https://doi.org/10.1016/j.cell.2007.01.043
45 https://doi.org/10.1016/j.cell.2012.12.033
46 https://doi.org/10.1016/j.cub.2005.12.042
47 https://doi.org/10.1016/j.febslet.2005.01.032
48 https://doi.org/10.1016/j.jhep.2010.12.021
49 https://doi.org/10.1016/j.molcel.2011.02.034
50 https://doi.org/10.1016/j.neurobiolaging.2006.08.004
51 https://doi.org/10.1016/j.neuron.2012.06.026
52 https://doi.org/10.1016/j.pneurobio.2010.01.001
53 https://doi.org/10.1016/s0002-9440(10)65721-5
54 https://doi.org/10.1016/s0896-6273(04)00017-0
55 https://doi.org/10.1073/pnas.0308512100
56 https://doi.org/10.1073/pnas.0906811106
57 https://doi.org/10.1074/jbc.m111692200
58 https://doi.org/10.1074/jbc.m808759200
59 https://doi.org/10.1091/mbc.e07-04-0327
60 https://doi.org/10.1093/carcin/5.10.1277
61 https://doi.org/10.1093/emboj/cdg082
62 https://doi.org/10.1093/hmg/ddm011
63 https://doi.org/10.1093/hmg/ddr432
64 https://doi.org/10.1093/nar/gki584
65 https://doi.org/10.1093/nar/gkm226
66 https://doi.org/10.1093/nar/gks1024
67 https://doi.org/10.1101/cshperspect.a011585
68 https://doi.org/10.1101/gr.229102
69 https://doi.org/10.1111/j.1474-9726.2011.00778.x
70 https://doi.org/10.1126/science.1062382
71 https://doi.org/10.1146/annurev-genet-110410-132541
72 https://doi.org/10.1146/annurev.neuro.24.1.1121
73 https://doi.org/10.1172/jci28769
74 https://doi.org/10.1242/jcs.02907
75 https://doi.org/10.1371/journal.pbio.1001371
76 https://doi.org/10.1371/journal.pgen.1000435
77 https://doi.org/10.1371/journal.pone.0002600
78 https://doi.org/10.1371/journal.pone.0024134
79 https://doi.org/10.1523/jneurosci.18-20-08126.1998
80 https://doi.org/10.3390/ijms12095461
81 schema:datePublished 2014-03
82 schema:datePublishedReg 2014-03-01
83 schema:description The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer's disease. Previous studies have linked oxidative stress and subsequent DNA damage to neuronal death in Alzheimer's disease and related tauopathies. Given that DNA damage can substantially alter chromatin structure, we examined epigenetic changes in tau-induced neurodegeneration. We found widespread loss of heterochromatin in tau transgenic Drosophila and mice and in human Alzheimer's disease. Notably, genetic rescue of tau-induced heterochromatin loss substantially reduced neurodegeneration in Drosophila. We identified oxidative stress and subsequent DNA damage as a mechanistic link between transgenic tau expression and heterochromatin relaxation, and found that heterochromatin loss permitted aberrant gene expression in tauopathies. Furthermore, large-scale analyses from the brains of individuals with Alzheimer's disease revealed a widespread transcriptional increase in genes that were heterochromatically silenced in controls. Our results establish heterochromatin loss as a toxic effector of tau-induced neurodegeneration and identify chromatin structure as a potential therapeutic target in Alzheimer's disease.
84 schema:genre research_article
85 schema:inLanguage en
86 schema:isAccessibleForFree true
87 schema:isPartOf N4b5d51deac254a92942b7cf43d3c6b78
88 Nbb25ff55031543b6bedacf8ad7aafdcb
89 sg:journal.1118362
90 schema:name Tau promotes neurodegeneration through global chromatin relaxation
91 schema:pagination 357-366
92 schema:productId N1ca5a472afb7487aab702ede31c2c242
93 N2394fd5e3d9548e496d9c92b9b769d6b
94 N50e0ff2066cf47b8839e224d69c95c2c
95 N9449a6c0131c41ea8c60c472b16b16fe
96 Nd3ea9d4d95854b238d4495e37e183e9d
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022076812
98 https://doi.org/10.1038/nn.3639
99 schema:sdDatePublished 2019-04-10T20:03
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N0984a58563404ee69416738ca3dde4e9
102 schema:url http://www.nature.com/neuro/journal/v17/n3/full/nn.3639.html
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N022a6815f8394677a8ba8b8ed35a5274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N0902b6bcb8d94f60880dfc731bc93640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Heterochromatin
111 rdf:type schema:DefinedTerm
112 N0984a58563404ee69416738ca3dde4e9 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N174145bac1b14633b9d3ab0feaf8c6e7 rdf:first sg:person.01171055310.28
115 rdf:rest rdf:nil
116 N1bf65ac645574d6c87b13f8eb440639d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 N1ca5a472afb7487aab702ede31c2c242 schema:name pubmed_id
120 schema:value 24464041
121 rdf:type schema:PropertyValue
122 N1cf2d46b105744c0abe368f508cb23e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Alzheimer Disease
124 rdf:type schema:DefinedTerm
125 N2394fd5e3d9548e496d9c92b9b769d6b schema:name readcube_id
126 schema:value 692dc00c67fe8adfea668e5b86714d926f71b5c7520d5e6cc23f8bb33e3666fe
127 rdf:type schema:PropertyValue
128 N23b01d4d6c7c4de488085e643a6a361b schema:name Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
129 rdf:type schema:Organization
130 N34008842498e4215a69ec62c945721b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals, Genetically Modified
132 rdf:type schema:DefinedTerm
133 N3c397342b1b346b7adf3b54c77e2fe17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Aged, 80 and over
135 rdf:type schema:DefinedTerm
136 N4b5d51deac254a92942b7cf43d3c6b78 schema:issueNumber 3
137 rdf:type schema:PublicationIssue
138 N50e0ff2066cf47b8839e224d69c95c2c schema:name dimensions_id
139 schema:value pub.1022076812
140 rdf:type schema:PropertyValue
141 N55c5afa5943a49919132fa8ed86a1930 rdf:first sg:person.01262325312.54
142 rdf:rest Nd0f55ee65bcb45008eca3d3ac36da08e
143 N6b85f3d7880d437494315b01dc9727e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Drosophila melanogaster
145 rdf:type schema:DefinedTerm
146 N9449a6c0131c41ea8c60c472b16b16fe schema:name nlm_unique_id
147 schema:value 9809671
148 rdf:type schema:PropertyValue
149 N96b10c95133e4916a9796eff5a422f37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Aged
151 rdf:type schema:DefinedTerm
152 N98ccf41dd4fb4da2801064f9a3f62a33 schema:name Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
153 rdf:type schema:Organization
154 Na5b8d4b500e84760b66fbbb524e52535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Animals
156 rdf:type schema:DefinedTerm
157 Na67e327e6eef40a7b2036a817e47f91b rdf:first sg:person.01166043302.04
158 rdf:rest N174145bac1b14633b9d3ab0feaf8c6e7
159 Na74fd5b0fd664a629aa36cde927849d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mice
161 rdf:type schema:DefinedTerm
162 Nbb25ff55031543b6bedacf8ad7aafdcb schema:volumeNumber 17
163 rdf:type schema:PublicationVolume
164 Nc49ada0f870443b5ad965a6ca3e6139a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name tau Proteins
166 rdf:type schema:DefinedTerm
167 Ncc12764fdf6346f5ad5d0c9502e2d1ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Female
169 rdf:type schema:DefinedTerm
170 Nccc52081b0794def8b7823621f0a4191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Brain
172 rdf:type schema:DefinedTerm
173 Nd0f55ee65bcb45008eca3d3ac36da08e rdf:first sg:person.0777452173.73
174 rdf:rest Na67e327e6eef40a7b2036a817e47f91b
175 Nd3ea9d4d95854b238d4495e37e183e9d schema:name doi
176 schema:value 10.1038/nn.3639
177 rdf:type schema:PropertyValue
178 Ne94f1f9cdf934a37963372ff54705adc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Mice, Inbred C57BL
180 rdf:type schema:DefinedTerm
181 Nee970f5114c141c98ee41c8b3ea8084c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Disease Models, Animal
183 rdf:type schema:DefinedTerm
184 Nf038ad8a60b3499da1adacf7416cbf7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Tauopathies
186 rdf:type schema:DefinedTerm
187 Nfa363eba1fc84bf98c213fb262a729d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Nerve Degeneration
189 rdf:type schema:DefinedTerm
190 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biological Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
194 schema:name Genetics
195 rdf:type schema:DefinedTerm
196 sg:grant.2369323 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
197 rdf:type schema:MonetaryGrant
198 sg:grant.2439252 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
199 rdf:type schema:MonetaryGrant
200 sg:grant.2448533 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
201 rdf:type schema:MonetaryGrant
202 sg:grant.2449081 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
203 rdf:type schema:MonetaryGrant
204 sg:grant.2520074 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
205 rdf:type schema:MonetaryGrant
206 sg:grant.2617826 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
207 rdf:type schema:MonetaryGrant
208 sg:grant.2696450 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
209 rdf:type schema:MonetaryGrant
210 sg:grant.3109462 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.3639
211 rdf:type schema:MonetaryGrant
212 sg:journal.1118362 schema:issn 1097-6256
213 1546-1726
214 schema:name Nature Neuroscience
215 rdf:type schema:Periodical
216 sg:person.01166043302.04 schema:affiliation https://www.grid.ac/institutes/grid.15276.37
217 schema:familyName Lewis
218 schema:givenName Jada
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166043302.04
220 rdf:type schema:Person
221 sg:person.01171055310.28 schema:affiliation N23b01d4d6c7c4de488085e643a6a361b
222 schema:familyName Feany
223 schema:givenName Mel B
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171055310.28
225 rdf:type schema:Person
226 sg:person.01262325312.54 schema:affiliation N98ccf41dd4fb4da2801064f9a3f62a33
227 schema:familyName Frost
228 schema:givenName Bess
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262325312.54
230 rdf:type schema:Person
231 sg:person.0777452173.73 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
232 schema:familyName Hemberg
233 schema:givenName Martin
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777452173.73
235 rdf:type schema:Person
236 sg:pub.10.1038/31508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030318669
237 https://doi.org/10.1038/31508
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/459927a schema:sameAs https://app.dimensions.ai/details/publication/pub.1043448162
240 https://doi.org/10.1038/459927a
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/78078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013225417
243 https://doi.org/10.1038/78078
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nature01126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016020461
246 https://doi.org/10.1038/nature01126
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nature04916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001506500
249 https://doi.org/10.1038/nature04916
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature04917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029225241
252 https://doi.org/10.1038/nature04917
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nbt1010-1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048301228
255 https://doi.org/10.1038/nbt1010-1045
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/ncb1528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030094308
258 https://doi.org/10.1038/ncb1528
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/ng1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026324467
261 https://doi.org/10.1038/ng1817
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nm1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035645372
264 https://doi.org/10.1038/nm1784
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nmeth.1906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003714959
267 https://doi.org/10.1038/nmeth.1906
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nn1774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001428427
270 https://doi.org/10.1038/nn1774
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nrn2967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000024338
273 https://doi.org/10.1038/nrn2967
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nrn2985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029769991
276 https://doi.org/10.1038/nrn2985
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nrneurol.2012.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037111415
279 https://doi.org/10.1038/nrneurol.2012.156
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/nsmb.1644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044654423
282 https://doi.org/10.1038/nsmb.1644
283 rdf:type schema:CreativeWork
284 sg:pub.10.1186/1471-2202-9-42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048107887
285 https://doi.org/10.1186/1471-2202-9-42
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/gb-2009-10-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583368
288 https://doi.org/10.1186/gb-2009-10-3-r25
289 rdf:type schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1083259853 schema:CreativeWork
291 https://doi.org/10.1002/ana.410430617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030056826
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/0092-8674(95)90216-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026628495
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/0197-4580(90)90542-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029525712
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.biolcel.2004.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040582651
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.cell.2007.01.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008754622
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.cell.2012.12.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052695631
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.cub.2005.12.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003730529
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.febslet.2005.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010823915
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jhep.2010.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017331469
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.molcel.2011.02.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050800227
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.neurobiolaging.2006.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038551375
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.neuron.2012.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031159843
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.pneurobio.2010.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002766973
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0002-9440(10)65721-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037136929
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0896-6273(04)00017-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011095495
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.0308512100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007985703
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.0906811106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008649415
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.m111692200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032061155
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1074/jbc.m808759200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043864473
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1091/mbc.e07-04-0327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015074057
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/carcin/5.10.1277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059452691
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/emboj/cdg082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027602190
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/hmg/ddm011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036516030
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/hmg/ddr432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021556015
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/nar/gki584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032994501
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/nar/gkm226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001245785
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1093/nar/gks1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013385393
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1101/cshperspect.a011585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017885288
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1101/gr.229102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022792016
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1111/j.1474-9726.2011.00778.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048392547
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1062382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039022937
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1146/annurev-genet-110410-132541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017940960
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1146/annurev.neuro.24.1.1121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045688590
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1172/jci28769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004657509
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1242/jcs.02907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046161035
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1371/journal.pbio.1001371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036070274
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1371/journal.pgen.1000435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030549218
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1371/journal.pone.0002600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019117739
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1371/journal.pone.0024134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024460279
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1523/jneurosci.18-20-08126.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083326123
370 rdf:type schema:CreativeWork
371 https://doi.org/10.3390/ijms12095461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015074823
372 rdf:type schema:CreativeWork
373 https://www.grid.ac/institutes/grid.15276.37 schema:alternateName University of Florida
374 schema:name Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, USA.
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
377 schema:name Department of Ophthalmology and Program in Neurobiology, Boston Children's Hospital, Boston, Massachusetts, USA.
378 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...