Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01-06

AUTHORS

Francesco Ferrini, Tuan Trang, Theresa-Alexandra M. Mattioli, Sophie Laffray, Thomas Del’Guidice, Louis-Etienne Lorenzo, Annie Castonguay, Nicolas Doyon, Wenbo Zhang, Antoine G. Godin, Daniela Mohr, Simon Beggs, Karen Vandal, Jean-Martin Beaulieu, Catherine Cahill, Michael W. Salter, Yves De Koninck

ABSTRACT

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K(+)-Cl(-) co-transporter KCC2, impairing Cl(-) homeostasis in rat spinal lamina l neurons. Restoring the anion equilibrium potential reversed the morphine-induced hyperalgesia without affecting tolerance. The hyperalgesia was also reversed by ablating spinal microglia. Morphine hyperalgesia, but not tolerance, required μ opioid receptor-dependent expression of P2X4 receptors (P2X4Rs) in microglia and μ-independent gating of the release of brain-derived neurotrophic factor (BDNF) by P2X4Rs. Blocking BDNF-TrkB signaling preserved Cl(-) homeostasis and reversed the hyperalgesia. Gene-targeted mice in which Bdnf was deleted from microglia did not develop hyperalgesia to morphine. However, neither morphine antinociception nor tolerance was affected in these mice. Our findings dissociate morphine-induced hyperalgesia from tolerance and suggest the microglia-to-neuron P2X4-BDNF-KCC2 pathway as a therapeutic target for preventing hyperalgesia without affecting morphine analgesia. More... »

PAGES

183-192

Journal

TITLE

Nature Neuroscience

ISSUE

2

VOLUME

16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.3295

DOI

http://dx.doi.org/10.1038/nn.3295

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004976264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23292683


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