A readily retrievable pool of synaptic vesicles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

Yunfeng Hua, Raunak Sinha, Cora S Thiel, Roman Schmidt, Jana Hüve, Henrik Martens, Stefan W Hell, Alexander Egner, Jurgen Klingauf

ABSTRACT

Although clathrin-mediated endocytosis is thought to be the predominant mechanism of synaptic vesicle recycling, it seems to be too slow for fast recycling. Therefore, it was suggested that a presorted and preassembled pool of synaptic vesicle proteins on the presynaptic membrane might support a first wave of fast clathrin-mediated endocytosis. In this study we monitored the temporal dynamics of such a 'readily retrievable pool' of synaptic vesicle proteins in rat hippocampal neurons using a new type of probe. By applying cypHer5E, a new cyanine dye-based pH-sensitive exogenous marker, coupled to antibodies to luminal domains of synaptic vesicle proteins, we could reliably monitor synaptic vesicle recycling and demonstrate the preferential recruitment of a surface pool of synaptic vesicle proteins upon stimulated endocytosis. By using fluorescence nanoscopy of surface-labeled synaptotagmin 1, we could resolve the spatial distribution of the surface pool at the periactive zone in hippocampal boutons, which represent putative sites of endocytosis. More... »

PAGES

833

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nn.2838

    DOI

    http://dx.doi.org/10.1038/nn.2838

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004205120

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21666673


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