Skn-1a (Pou2f3) specifies taste receptor cell lineage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Ichiro Matsumoto, Makoto Ohmoto, Masataka Narukawa, Yoshihiro Yoshihara, Keiko Abe

ABSTRACT

Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells. More... »

PAGES

685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2820

DOI

http://dx.doi.org/10.1038/nn.2820

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011933189

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21572433


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