5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Yong Xu, Eric D Berglund, Jong-Woo Sohn, William L Holland, Jen-Chieh Chuang, Makoto Fukuda, Jari Rossi, Kevin W Williams, Juli E Jones, Jeffrey M Zigman, Bradford B Lowell, Philipp E Scherer, Joel K Elmquist

ABSTRACT

Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished the anti-diabetic effects of meta-chlorophenylpiperazine (a 5-HT(2C)R agonist); these effects were restored when 5-HT(2C)Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver. More... »

PAGES

1457

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2664

DOI

http://dx.doi.org/10.1038/nn.2664

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023036195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21037584


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