GSK-3 is a master regulator of neural progenitor homeostasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10-04

AUTHORS

Woo-Yang Kim, Xinshuo Wang, Yaohong Wu, Bradley W Doble, Satish Patel, James R Woodgett, William D Snider

ABSTRACT

The authors report the conditional deletion of the alpha and beta forms of glycogen synthase kinase 3 (GSK-3) in mouse neural progenitors. This deletion is associated with dysregulations in β-catenin, Sonic Hedgehog, Notch and fibroblast growth factor signaling pathways and leads to markedly increased proliferation of neural progenitors.

PAGES

1390-1397

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2408

DOI

http://dx.doi.org/10.1038/nn.2408

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012323259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19801986


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