Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-05-17

AUTHORS

Andrée Gauthier-Fisher, Dan C Lin, Melissa Greeve, David R Kaplan, Robert Rottapel, Freda D Miller

ABSTRACT

Neurogenesis requires a switch of progenitor divisions from symmetrical and self-renewing to asymmetrical. This study shows that the Rho-activating protein Lcf is required for neurogenesis in the murine cortex and that its negative regulator Tctex-1 conversely acts to allow self-renewing symmetrical progenitor division.

PAGES

735-744

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2339

DOI

http://dx.doi.org/10.1038/nn.2339

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052868780

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19448628


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