HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07

AUTHORS

Feng Ye, Ying Chen, ThaoNguyen Hoang, Rusty L Montgomery, Xian-hui Zhao, Hong Bu, Tom Hu, Makoto M Taketo, Johan H van Es, Hans Clevers, Jenny Hsieh, Rhonda Bassel-Duby, Eric N Olson, Q Richard Lu

ABSTRACT

Oligodendrocyte development is regulated by the interaction of repressors and activators in a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 and HDAC2, were required for oligodendrocyte formation. Genetic deletion of both Hdac1 and Hdac2 in oligodendrocyte lineage cells resulted in stabilization and nuclear translocation of beta-catenin, which negatively regulates oligodendrocyte development by repressing Olig2 expression. We further identified the oligodendrocyte-restricted transcription factor TCF7L2/TCF4 as a bipartite co-effector of beta-catenin for regulating oligodendrocyte differentiation. Targeted disruption of Tcf7l2 in mice led to severe defects in oligodendrocyte maturation, whereas expression of its dominant-repressive form promoted precocious oligodendrocyte specification in developing chick neural tube. Transcriptional co-repressors HDAC1 and HDAC2 compete with beta-catenin for TCF7L2 interaction to regulate downstream genes involved in oligodendrocyte differentiation. Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation. More... »

PAGES

829-838

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2333

DOI

http://dx.doi.org/10.1038/nn.2333

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006528138

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19503085


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chick Embryo", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligodendroglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred F344", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Cord", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TCF Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor 7-Like 2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA.", 
            "Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ye", 
        "givenName": "Feng", 
        "id": "sg:person.01102216623.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102216623.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Ying", 
        "id": "sg:person.01313444453.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313444453.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoang", 
        "givenName": "ThaoNguyen", 
        "id": "sg:person.0636153553.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636153553.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montgomery", 
        "givenName": "Rusty L", 
        "id": "sg:person.01174150014.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174150014.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Xian-hui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bu", 
        "givenName": "Hong", 
        "id": "sg:person.01205213405.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205213405.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Tom", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taketo", 
        "givenName": "Makoto M", 
        "id": "sg:person.011203742777.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011203742777.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hubrecht Institute", 
          "id": "https://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Hubrecht Institute, Utrecht, The Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Es", 
        "givenName": "Johan H", 
        "id": "sg:person.01064467353.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064467353.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hubrecht Institute", 
          "id": "https://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Hubrecht Institute, Utrecht, The Netherlands."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clevers", 
        "givenName": "Hans", 
        "id": "sg:person.0662243670.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662243670.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsieh", 
        "givenName": "Jenny", 
        "id": "sg:person.014504376417.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014504376417.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bassel-Duby", 
        "givenName": "Rhonda", 
        "id": "sg:person.0666540614.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666540614.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olson", 
        "givenName": "Eric N", 
        "id": "sg:person.0745133622.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745133622.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West China Second University Hospital of Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.461863.e", 
          "name": [
            "Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA.", 
            "Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.", 
            "West China Second University Hospital, Sichuan University, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Q Richard", 
        "id": "sg:person.0644244251.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644244251.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jnr.10080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001712167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695839", 
          "https://doi.org/10.1038/1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002695839", 
          "https://doi.org/10.1038/1270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00926-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006917223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00677-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007590081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)80026-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008426340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80515-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008870486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2004.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009145923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/364501a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009978279", 
          "https://doi.org/10.1038/364501a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0434590100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011199984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012375459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00248-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016525326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mod.2005.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017040125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017708293", 
          "https://doi.org/10.1038/sj.onc.1210320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/21.10.2303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019819891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022626729", 
          "https://doi.org/10.1038/nprot.2007.149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022626729", 
          "https://doi.org/10.1038/nprot.2007.149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023003326", 
          "https://doi.org/10.1038/nrd2133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023003326", 
          "https://doi.org/10.1038/nrd2133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(03)00637-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024313365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024975353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025905692", 
          "https://doi.org/10.1038/nn.2172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2005.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026222306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2005.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026222306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)00237-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027869714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111635200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029834842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1563807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029849617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.9.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030817666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030839891", 
          "https://doi.org/10.1038/5007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030839891", 
          "https://doi.org/10.1038/5007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033300049", 
          "https://doi.org/10.1038/nrc1779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033300049", 
          "https://doi.org/10.1038/nrc1779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m107742200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033714108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3034-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036141070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1686208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036394820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(03)00360-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037746945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00678-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039454879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.03.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039799535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040006580", 
          "https://doi.org/10.1038/ng1521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040006580", 
          "https://doi.org/10.1038/ng1521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040497371", 
          "https://doi.org/10.1038/ng1095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040497371", 
          "https://doi.org/10.1038/ng1095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041684641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200412101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041950086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200412101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041950086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-1-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042905963", 
          "https://doi.org/10.1186/1471-213x-1-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.7.1410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046408423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.8.4088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047498147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.18.6882-6890.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049037140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200308101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049313883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.21.5931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049664537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4547(19960201)43:3<299::aid-jnr5>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052056451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490380602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053279506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075035367", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-21-09221.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075186199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-23-10333.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075195988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082430284", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082615421", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-07", 
    "datePublishedReg": "2009-07-01", 
    "description": "Oligodendrocyte development is regulated by the interaction of repressors and activators in a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 and HDAC2, were required for oligodendrocyte formation. Genetic deletion of both Hdac1 and Hdac2 in oligodendrocyte lineage cells resulted in stabilization and nuclear translocation of beta-catenin, which negatively regulates oligodendrocyte development by repressing Olig2 expression. We further identified the oligodendrocyte-restricted transcription factor TCF7L2/TCF4 as a bipartite co-effector of beta-catenin for regulating oligodendrocyte differentiation. Targeted disruption of Tcf7l2 in mice led to severe defects in oligodendrocyte maturation, whereas expression of its dominant-repressive form promoted precocious oligodendrocyte specification in developing chick neural tube. Transcriptional co-repressors HDAC1 and HDAC2 compete with beta-catenin for TCF7L2 interaction to regulate downstream genes involved in oligodendrocyte differentiation. Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nn.2333", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2561225", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the \u03b2-catenin\u2013TCF interaction", 
    "pagination": "829-838", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1f183d374b29644b7307d792eab9df3fc27750095bfb8f9e6f4971f62765b71a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19503085"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9809671"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn.2333"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006528138"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn.2333", 
      "https://app.dimensions.ai/details/publication/pub.1006528138"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nn.2333"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn.2333'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn.2333'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn.2333'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn.2333'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      21 PREDICATES      103 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn.2333 schema:about N11620d5eea6a4b96ac8f99bb8163b720
2 N1679dcf013e3448ab8b1f6798b3be778
3 N181b671e14ba428790f8669aab7fd520
4 N2222f00fde0e4d56b599ca60d30e13c6
5 N3760fe632a774944a4bc2c6b7bc8f353
6 N3ea88ae328a747f0bf51a9c0aabb34a1
7 N556f66ec1f794cf3b6f0a5807ee4c33c
8 N65ffc94222f84b679d73d787eadee242
9 N6c99884b95574051878975e95429d683
10 N6fc86a83576a454288c4e8cd81b8b9c6
11 N7458170b1bc3480abbd01b6c368b472a
12 N7c531469815c4441879164e29703718f
13 N811b452750b24e07969d68c833a986ee
14 N9e87bc89667c4fbbb12918f7c8bce9b2
15 Nb75752d2b4ce410f80e070dc48cbb1d1
16 Nc88a299d924641c4bdbf15898e9d0fdd
17 Ncebea34609304652b3bbdd45e8ff5eaa
18 Ne6d7dd6e693b4c13b1da849d17a5d19c
19 Ne7152f56d6444662b9e829f2be9b207a
20 Nf27de487fe0c450796c29be35f3c796d
21 Nf2fc6b5763694f938f711b11f8655d1a
22 Nf4d7f7b3a5cc4b6e862c98be030bb27e
23 Nf5bbe4a0231e44659848f343453e9fa3
24 Nfe06e2c4b8cb4b179bbcf09cc11c4bac
25 anzsrc-for:06
26 anzsrc-for:0604
27 schema:author N85c6f863e235407eb95a089148abfdcf
28 schema:citation sg:pub.10.1038/1270
29 sg:pub.10.1038/364501a0
30 sg:pub.10.1038/5007
31 sg:pub.10.1038/ng1095
32 sg:pub.10.1038/ng1521
33 sg:pub.10.1038/nn.2172
34 sg:pub.10.1038/nprot.2007.149
35 sg:pub.10.1038/nrc1779
36 sg:pub.10.1038/nrd2133
37 sg:pub.10.1038/sj.onc.1210320
38 sg:pub.10.1186/1471-213x-1-4
39 https://app.dimensions.ai/details/publication/pub.1075035367
40 https://app.dimensions.ai/details/publication/pub.1082430284
41 https://app.dimensions.ai/details/publication/pub.1082615421
42 https://doi.org/10.1002/(sici)1097-4547(19960201)43:3<299::aid-jnr5>3.0.co;2-e
43 https://doi.org/10.1002/jnr.10080
44 https://doi.org/10.1002/jnr.490380602
45 https://doi.org/10.1016/j.ceb.2005.09.002
46 https://doi.org/10.1016/j.cell.2006.10.018
47 https://doi.org/10.1016/j.jmb.2004.02.006
48 https://doi.org/10.1016/j.mod.2005.10.005
49 https://doi.org/10.1016/j.ydbio.2005.03.020
50 https://doi.org/10.1016/s0092-8674(02)00677-3
51 https://doi.org/10.1016/s0092-8674(02)00678-5
52 https://doi.org/10.1016/s0092-8674(04)00248-x
53 https://doi.org/10.1016/s0896-6273(00)80515-2
54 https://doi.org/10.1016/s0896-6273(01)00237-9
55 https://doi.org/10.1016/s0896-6273(01)80026-x
56 https://doi.org/10.1016/s0896-6273(03)00637-8
57 https://doi.org/10.1016/s0960-9822(02)00926-0
58 https://doi.org/10.1016/s1534-5807(03)00360-5
59 https://doi.org/10.1073/pnas.0434590100
60 https://doi.org/10.1074/jbc.m107742200
61 https://doi.org/10.1074/jbc.m111635200
62 https://doi.org/10.1083/jcb.200308101
63 https://doi.org/10.1083/jcb.200412101
64 https://doi.org/10.1093/emboj/18.21.5931
65 https://doi.org/10.1093/emboj/19.9.1998
66 https://doi.org/10.1093/emboj/21.10.2303
67 https://doi.org/10.1093/nar/29.7.1410
68 https://doi.org/10.1101/gad.1563807
69 https://doi.org/10.1101/gad.1686208
70 https://doi.org/10.1126/science.275.5307.1784
71 https://doi.org/10.1128/mcb.16.8.4088
72 https://doi.org/10.1128/mcb.20.18.6882-6890.2000
73 https://doi.org/10.1242/dev.01881
74 https://doi.org/10.1242/dev.02522
75 https://doi.org/10.1523/jneurosci.22-21-09221.2002
76 https://doi.org/10.1523/jneurosci.22-23-10333.2002
77 https://doi.org/10.1523/jneurosci.3034-04.2005
78 schema:datePublished 2009-07
79 schema:datePublishedReg 2009-07-01
80 schema:description Oligodendrocyte development is regulated by the interaction of repressors and activators in a complex transcriptional network. We found that two histone-modifying enzymes, HDAC1 and HDAC2, were required for oligodendrocyte formation. Genetic deletion of both Hdac1 and Hdac2 in oligodendrocyte lineage cells resulted in stabilization and nuclear translocation of beta-catenin, which negatively regulates oligodendrocyte development by repressing Olig2 expression. We further identified the oligodendrocyte-restricted transcription factor TCF7L2/TCF4 as a bipartite co-effector of beta-catenin for regulating oligodendrocyte differentiation. Targeted disruption of Tcf7l2 in mice led to severe defects in oligodendrocyte maturation, whereas expression of its dominant-repressive form promoted precocious oligodendrocyte specification in developing chick neural tube. Transcriptional co-repressors HDAC1 and HDAC2 compete with beta-catenin for TCF7L2 interaction to regulate downstream genes involved in oligodendrocyte differentiation. Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree true
84 schema:isPartOf N2a973d9660774834ba31af1b2a172b1b
85 N3cd941386f564fb29f41aac1acf045ab
86 sg:journal.1118362
87 schema:name HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction
88 schema:pagination 829-838
89 schema:productId N2378ea3c0876403caa0157d77ec9ecd3
90 N42021636a00f46ee91a3a9e6c27a58dc
91 N49e37e1b3b684055ba0b06507bb80b82
92 Ne818b715539b4ab9922aaccce5336561
93 Nfb41a5602ccd4e448e4dded5679dac8a
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006528138
95 https://doi.org/10.1038/nn.2333
96 schema:sdDatePublished 2019-04-10T16:28
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher Nd0bc6444906348fd8d1d7673d624a58a
99 schema:url http://www.nature.com/articles/nn.2333
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N11620d5eea6a4b96ac8f99bb8163b720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N1679dcf013e3448ab8b1f6798b3be778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Chick Embryo
108 rdf:type schema:DefinedTerm
109 N181b671e14ba428790f8669aab7fd520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Wnt Proteins
111 rdf:type schema:DefinedTerm
112 N1d527d3481b8403ba0288b6873d81105 rdf:first N418581eebe6742a78017fd5d390cc8a1
113 rdf:rest N9b4470a766074cd3b46b16def897965a
114 N2222f00fde0e4d56b599ca60d30e13c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Repressor Proteins
116 rdf:type schema:DefinedTerm
117 N2378ea3c0876403caa0157d77ec9ecd3 schema:name nlm_unique_id
118 schema:value 9809671
119 rdf:type schema:PropertyValue
120 N24d421af40fc45f3aeb3741f3ef83e96 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
121 schema:familyName Hu
122 schema:givenName Tom
123 rdf:type schema:Person
124 N2a973d9660774834ba31af1b2a172b1b schema:volumeNumber 12
125 rdf:type schema:PublicationVolume
126 N3760fe632a774944a4bc2c6b7bc8f353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name TCF Transcription Factors
128 rdf:type schema:DefinedTerm
129 N3bd47af648634544b0c952434cfe9d48 rdf:first sg:person.01313444453.07
130 rdf:rest N5f4c586481704bf38e4beb2712b850cd
131 N3cd941386f564fb29f41aac1acf045ab schema:issueNumber 7
132 rdf:type schema:PublicationIssue
133 N3ea88ae328a747f0bf51a9c0aabb34a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mice
135 rdf:type schema:DefinedTerm
136 N418581eebe6742a78017fd5d390cc8a1 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
137 schema:familyName Zhao
138 schema:givenName Xian-hui
139 rdf:type schema:Person
140 N42021636a00f46ee91a3a9e6c27a58dc schema:name doi
141 schema:value 10.1038/nn.2333
142 rdf:type schema:PropertyValue
143 N49e37e1b3b684055ba0b06507bb80b82 schema:name pubmed_id
144 schema:value 19503085
145 rdf:type schema:PropertyValue
146 N516c132d73d44c1cae988a6ae8279d80 rdf:first sg:person.014504376417.85
147 rdf:rest Nd741bd0aca274f4ba972bf793b3e33fc
148 N556f66ec1f794cf3b6f0a5807ee4c33c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name beta Catenin
150 rdf:type schema:DefinedTerm
151 N5f4c586481704bf38e4beb2712b850cd rdf:first sg:person.0636153553.59
152 rdf:rest Nff58623beb78499ab5115e7e38304d14
153 N65ffc94222f84b679d73d787eadee242 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Rats
155 rdf:type schema:DefinedTerm
156 N6c99884b95574051878975e95429d683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mutation
158 rdf:type schema:DefinedTerm
159 N6fc86a83576a454288c4e8cd81b8b9c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Rats, Inbred F344
161 rdf:type schema:DefinedTerm
162 N7458170b1bc3480abbd01b6c368b472a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Histone Deacetylase 1
164 rdf:type schema:DefinedTerm
165 N7c531469815c4441879164e29703718f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 N7f07129ce5c44eddacb6916811659d1d schema:name Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, China.
169 rdf:type schema:Organization
170 N811b452750b24e07969d68c833a986ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Histone Deacetylase 2
172 rdf:type schema:DefinedTerm
173 N85c6f863e235407eb95a089148abfdcf rdf:first sg:person.01102216623.15
174 rdf:rest N3bd47af648634544b0c952434cfe9d48
175 N96310a4058654deab4e920efdc8868b5 rdf:first sg:person.01064467353.67
176 rdf:rest Nde78017ec0cf4f04b0fcab7a7af0558b
177 N9b4470a766074cd3b46b16def897965a rdf:first sg:person.01205213405.06
178 rdf:rest Nc8107b994bdc4344b0b12fc524707ba0
179 N9e87bc89667c4fbbb12918f7c8bce9b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Brain
181 rdf:type schema:DefinedTerm
182 Na30468ed8a2b43938ad71fa782910043 rdf:first sg:person.0644244251.67
183 rdf:rest rdf:nil
184 Na8367a63f2c9480d8a9654506cc265d6 rdf:first sg:person.011203742777.08
185 rdf:rest N96310a4058654deab4e920efdc8868b5
186 Nb75752d2b4ce410f80e070dc48cbb1d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Motor Neurons
188 rdf:type schema:DefinedTerm
189 Nc8107b994bdc4344b0b12fc524707ba0 rdf:first N24d421af40fc45f3aeb3741f3ef83e96
190 rdf:rest Na8367a63f2c9480d8a9654506cc265d6
191 Nc88a299d924641c4bdbf15898e9d0fdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Cells, Cultured
193 rdf:type schema:DefinedTerm
194 Ncceb0d4252d04918bcb7d1c8c7bb01c6 rdf:first sg:person.0745133622.48
195 rdf:rest Na30468ed8a2b43938ad71fa782910043
196 Ncebea34609304652b3bbdd45e8ff5eaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Mice, Transgenic
198 rdf:type schema:DefinedTerm
199 Nd0bc6444906348fd8d1d7673d624a58a schema:name Springer Nature - SN SciGraph project
200 rdf:type schema:Organization
201 Nd741bd0aca274f4ba972bf793b3e33fc rdf:first sg:person.0666540614.00
202 rdf:rest Ncceb0d4252d04918bcb7d1c8c7bb01c6
203 Nde78017ec0cf4f04b0fcab7a7af0558b rdf:first sg:person.0662243670.45
204 rdf:rest N516c132d73d44c1cae988a6ae8279d80
205 Ne6d7dd6e693b4c13b1da849d17a5d19c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Astrocytes
207 rdf:type schema:DefinedTerm
208 Ne7152f56d6444662b9e829f2be9b207a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Signal Transduction
210 rdf:type schema:DefinedTerm
211 Ne818b715539b4ab9922aaccce5336561 schema:name dimensions_id
212 schema:value pub.1006528138
213 rdf:type schema:PropertyValue
214 Nf27de487fe0c450796c29be35f3c796d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Spinal Cord
216 rdf:type schema:DefinedTerm
217 Nf2fc6b5763694f938f711b11f8655d1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Oligodendroglia
219 rdf:type schema:DefinedTerm
220 Nf4d7f7b3a5cc4b6e862c98be030bb27e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Histone Deacetylases
222 rdf:type schema:DefinedTerm
223 Nf5bbe4a0231e44659848f343453e9fa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Cell Differentiation
225 rdf:type schema:DefinedTerm
226 Nfb41a5602ccd4e448e4dded5679dac8a schema:name readcube_id
227 schema:value 1f183d374b29644b7307d792eab9df3fc27750095bfb8f9e6f4971f62765b71a
228 rdf:type schema:PropertyValue
229 Nfe06e2c4b8cb4b179bbcf09cc11c4bac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Transcription Factor 7-Like 2 Protein
231 rdf:type schema:DefinedTerm
232 Nff58623beb78499ab5115e7e38304d14 rdf:first sg:person.01174150014.25
233 rdf:rest N1d527d3481b8403ba0288b6873d81105
234 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
235 schema:name Biological Sciences
236 rdf:type schema:DefinedTerm
237 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
238 schema:name Genetics
239 rdf:type schema:DefinedTerm
240 sg:grant.2561225 http://pending.schema.org/fundedItem sg:pub.10.1038/nn.2333
241 rdf:type schema:MonetaryGrant
242 sg:journal.1118362 schema:issn 1097-6256
243 1546-1726
244 schema:name Nature Neuroscience
245 rdf:type schema:Periodical
246 sg:person.01064467353.67 schema:affiliation https://www.grid.ac/institutes/grid.419927.0
247 schema:familyName van Es
248 schema:givenName Johan H
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064467353.67
250 rdf:type schema:Person
251 sg:person.01102216623.15 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
252 schema:familyName Ye
253 schema:givenName Feng
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102216623.15
255 rdf:type schema:Person
256 sg:person.011203742777.08 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
257 schema:familyName Taketo
258 schema:givenName Makoto M
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011203742777.08
260 rdf:type schema:Person
261 sg:person.01174150014.25 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
262 schema:familyName Montgomery
263 schema:givenName Rusty L
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174150014.25
265 rdf:type schema:Person
266 sg:person.01205213405.06 schema:affiliation N7f07129ce5c44eddacb6916811659d1d
267 schema:familyName Bu
268 schema:givenName Hong
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205213405.06
270 rdf:type schema:Person
271 sg:person.01313444453.07 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
272 schema:familyName Chen
273 schema:givenName Ying
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313444453.07
275 rdf:type schema:Person
276 sg:person.014504376417.85 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
277 schema:familyName Hsieh
278 schema:givenName Jenny
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014504376417.85
280 rdf:type schema:Person
281 sg:person.0636153553.59 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
282 schema:familyName Hoang
283 schema:givenName ThaoNguyen
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636153553.59
285 rdf:type schema:Person
286 sg:person.0644244251.67 schema:affiliation https://www.grid.ac/institutes/grid.461863.e
287 schema:familyName Lu
288 schema:givenName Q Richard
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644244251.67
290 rdf:type schema:Person
291 sg:person.0662243670.45 schema:affiliation https://www.grid.ac/institutes/grid.419927.0
292 schema:familyName Clevers
293 schema:givenName Hans
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662243670.45
295 rdf:type schema:Person
296 sg:person.0666540614.00 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
297 schema:familyName Bassel-Duby
298 schema:givenName Rhonda
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666540614.00
300 rdf:type schema:Person
301 sg:person.0745133622.48 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
302 schema:familyName Olson
303 schema:givenName Eric N
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745133622.48
305 rdf:type schema:Person
306 sg:pub.10.1038/1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002695839
307 https://doi.org/10.1038/1270
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/364501a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009978279
310 https://doi.org/10.1038/364501a0
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/5007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839891
313 https://doi.org/10.1038/5007
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/ng1095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040497371
316 https://doi.org/10.1038/ng1095
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/ng1521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040006580
319 https://doi.org/10.1038/ng1521
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/nn.2172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025905692
322 https://doi.org/10.1038/nn.2172
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/nprot.2007.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022626729
325 https://doi.org/10.1038/nprot.2007.149
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/nrc1779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033300049
328 https://doi.org/10.1038/nrc1779
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/nrd2133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023003326
331 https://doi.org/10.1038/nrd2133
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/sj.onc.1210320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017708293
334 https://doi.org/10.1038/sj.onc.1210320
335 rdf:type schema:CreativeWork
336 sg:pub.10.1186/1471-213x-1-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042905963
337 https://doi.org/10.1186/1471-213x-1-4
338 rdf:type schema:CreativeWork
339 https://app.dimensions.ai/details/publication/pub.1075035367 schema:CreativeWork
340 https://app.dimensions.ai/details/publication/pub.1082430284 schema:CreativeWork
341 https://app.dimensions.ai/details/publication/pub.1082615421 schema:CreativeWork
342 https://doi.org/10.1002/(sici)1097-4547(19960201)43:3<299::aid-jnr5>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1052056451
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1002/jnr.10080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001712167
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1002/jnr.490380602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053279506
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/j.ceb.2005.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026222306
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/j.cell.2006.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684641
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/j.jmb.2004.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009145923
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/j.mod.2005.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017040125
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/j.ydbio.2005.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039799535
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s0092-8674(02)00677-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007590081
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0092-8674(02)00678-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039454879
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s0092-8674(04)00248-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016525326
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s0896-6273(00)80515-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008870486
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/s0896-6273(01)00237-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027869714
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/s0896-6273(01)80026-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008426340
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/s0896-6273(03)00637-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024313365
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/s0960-9822(02)00926-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006917223
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/s1534-5807(03)00360-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037746945
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1073/pnas.0434590100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011199984
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1074/jbc.m107742200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033714108
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1074/jbc.m111635200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029834842
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1083/jcb.200308101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049313883
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1083/jcb.200412101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041950086
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1093/emboj/18.21.5931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049664537
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1093/emboj/19.9.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030817666
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1093/emboj/21.10.2303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019819891
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1093/nar/29.7.1410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046408423
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1101/gad.1563807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029849617
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1101/gad.1686208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036394820
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1126/science.275.5307.1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556119
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1128/mcb.16.8.4088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047498147
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1128/mcb.20.18.6882-6890.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049037140
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1242/dev.01881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012375459
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1242/dev.02522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024975353
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1523/jneurosci.22-21-09221.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075186199
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1523/jneurosci.22-23-10333.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075195988
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1523/jneurosci.3034-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036141070
413 rdf:type schema:CreativeWork
414 https://www.grid.ac/institutes/grid.258799.8 schema:alternateName Kyoto University
415 schema:name Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
418 schema:name Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
419 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
420 Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University, China.
421 rdf:type schema:Organization
422 https://www.grid.ac/institutes/grid.419927.0 schema:alternateName Hubrecht Institute
423 schema:name Hubrecht Institute, Utrecht, The Netherlands.
424 rdf:type schema:Organization
425 https://www.grid.ac/institutes/grid.461863.e schema:alternateName West China Second University Hospital of Sichuan University
426 schema:name Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
427 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
428 West China Second University Hospital, Sichuan University, China.
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...