Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-09

AUTHORS

Qingchun Tong, Chian-Ping Ye, Juli E Jones, Joel K Elmquist, Bradford B Lowell

ABSTRACT

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance. More... »

PAGES

998-1000

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2167

DOI

http://dx.doi.org/10.1038/nn.2167

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002524182

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19160495


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