Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-04-01

AUTHORS

Karun K Singh, Katya J Park, Elizabeth J Hong, Bianca M Kramer, Michael E Greenberg, David R Kaplan, Freda D Miller

ABSTRACT

The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning. Specifically, we found that pruning of rat and mouse sympathetic axons that project to the eye requires both activity-dependent BDNF and p75NTR. p75NTR and BDNF are also essential for activity-dependent axon pruning in culture, where they mediate pruning by directly causing axon degeneration. p75NTR, which is enriched in losing axons, causes axonal degeneration by suppressing TrkA-mediated signaling that is essential for axonal maintenance. These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration. More... »

PAGES

649-658

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn.2114

DOI

http://dx.doi.org/10.1038/nn.2114

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031858688

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18382462


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