Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05

AUTHORS

Stephen Soonthornvacharin, Ariel Rodriguez-Frandsen, Yingyao Zhou, Felipe Galvez, Nicholas J. Huffmaster, Shashank Tripathi, Vinod R. M. T. Balasubramaniam, Atsushi Inoue, Elisa de Castro, Hong Moulton, David A. Stein, María Teresa Sánchez-Aparicio, Paul D. De Jesus, Quy Nguyen, Renate König, Nevan J. Krogan, Adolfo García-Sastre, Sunnie M. Yoh, Sumit K. Chanda

ABSTRACT

Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular cofactors that regulate RIG-I signalling, we performed two global RNA interference analyses to identify both positive and negative regulatory nodes operating on the signalling pathway during virus infection. These factors were integrated with experimentally and computationally derived interactome data to build a RIG-I protein interaction network. Our analysis revealed diverse cellular processes, including the unfolded protein response, Wnt signalling and RNA metabolism, as critical cellular components governing innate responses to non-self RNA species. Importantly, we identified K-Homology Splicing Regulatory Protein (KHSRP) as a negative regulator of this pathway. We find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). Consistent with increased RIG-I antiviral signalling in the absence of KHSRP, viral replication is reduced when KHSRP expression is knocked down both in vitro and in vivo. Taken together, these data indicate that KHSRP functions as a checkpoint regulator of the innate immune response to pathogen challenge. More... »

PAGES

nmicrobiol201722

References to SciGraph publications

  • 2006-02. Antiviral innate immunity pathways in CELL RESEARCH
  • 2014-09. The SKIV2L RNA exosome limits activation of the RIG-I-like receptors in NATURE IMMUNOLOGY
  • 2012-11. Basal and stress-induced Hsp70 are modulated by ataxin-3 in CELL STRESS AND CHAPERONES
  • 2006-06. Negative regulation of interferon-regulatory factor 3–dependent innate antiviral response by the prolyl isomerase Pin1 in NATURE IMMUNOLOGY
  • 2004-07. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses in NATURE IMMUNOLOGY
  • 2007-10. A probability-based approach for the analysis of large-scale RNAi screens in NATURE METHODS
  • 2009-07. Regulation of the innate immune response by threonine-phosphatase of Eyes absent in NATURE
  • 2006-12. New low-viscosity overlay medium for viral plaque assays in VIROLOGY JOURNAL
  • 2012-01. Global landscape of HIV–human protein complexes in NATURE
  • 2005-10. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus in NATURE
  • 2006-05. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses in NATURE
  • 2013-11. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2013-09-18. Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection in NATURE
  • 2007-04. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity in NATURE
  • 2010-02-11. Human host factors required for influenza virus replication in NATURE
  • 2008-07. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA in NATURE
  • 2009-12. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmicrobiol.2017.22

    DOI

    http://dx.doi.org/10.1038/nmicrobiol.2017.22

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084129348

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28248290


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DEAD Box Protein 58", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HEK293 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Influenza A Virus, H1N1 Subtype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Interaction Mapping", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Interaction Maps", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA", 
                "Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soonthornvacharin", 
            "givenName": "Stephen", 
            "id": "sg:person.01032051536.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032051536.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodriguez-Frandsen", 
            "givenName": "Ariel", 
            "id": "sg:person.01162655176.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162655176.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Institute of the Novartis Research Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418185.1", 
              "name": [
                "Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Yingyao", 
            "id": "sg:person.01102561516.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102561516.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Galvez", 
            "givenName": "Felipe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huffmaster", 
            "givenName": "Nicholas J.", 
            "id": "sg:person.01317250141.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317250141.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai", 
              "id": "https://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA", 
                "Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tripathi", 
            "givenName": "Shashank", 
            "id": "sg:person.01175654043.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175654043.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai", 
              "id": "https://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA", 
                "Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Balasubramaniam", 
            "givenName": "Vinod R. M. T.", 
            "id": "sg:person.01062036517.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062036517.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Inoue", 
            "givenName": "Atsushi", 
            "id": "sg:person.012673345265.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012673345265.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai", 
              "id": "https://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA", 
                "Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Castro", 
            "givenName": "Elisa", 
            "id": "sg:person.0662322003.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662322003.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oregon State University", 
              "id": "https://www.grid.ac/institutes/grid.4391.f", 
              "name": [
                "Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, 450 SW 30th Street, Oregon 97331, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moulton", 
            "givenName": "Hong", 
            "id": "sg:person.01264246230.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264246230.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oregon State University", 
              "id": "https://www.grid.ac/institutes/grid.4391.f", 
              "name": [
                "Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, 450 SW 30th Street, Oregon 97331, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stein", 
            "givenName": "David A.", 
            "id": "sg:person.01073751341.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073751341.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai", 
              "id": "https://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA", 
                "Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00e1nchez-Aparicio", 
            "givenName": "Mar\u00eda Teresa", 
            "id": "sg:person.0671716101.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671716101.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Jesus", 
            "givenName": "Paul D.", 
            "id": "sg:person.01121140573.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121140573.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "Quy", 
            "id": "sg:person.01235367173.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235367173.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Paul Ehrlich Institut", 
              "id": "https://www.grid.ac/institutes/grid.425396.f", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "Host-Pathogen-Interactions, Paul-Ehrlich-Institute, German Center for Infection Research (DZIF), Paul-Ehrlich-Stra\u00dfe 51\u201359, 63225 Langen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "K\u00f6nig", 
            "givenName": "Renate", 
            "id": "sg:person.0764674043.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764674043.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Cellular and Molecular Pharmacology, University of California San Francisco, 1700 4th Street, Byers Hall 308D, Box 2530, San Francisco, California 94158, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krogan", 
            "givenName": "Nevan J.", 
            "id": "sg:person.0613100042.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613100042.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Icahn School of Medicine at Mount Sinai", 
              "id": "https://www.grid.ac/institutes/grid.59734.3c", 
              "name": [
                "Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA", 
                "Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA", 
                "Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garc\u00eda-Sastre", 
            "givenName": "Adolfo", 
            "id": "sg:person.01370061066.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370061066.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoh", 
            "givenName": "Sunnie M.", 
            "id": "sg:person.01333444233.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333444233.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chanda", 
            "givenName": "Sumit K.", 
            "id": "sg:person.01205153066.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205153066.16"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0960-9822(01)00487-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000785187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-422x-3-63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000911842", 
              "https://doi.org/10.1186/1743-422x-3-63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01258-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002166598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002914189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/jir.2013.0143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003453275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2004.08.071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003770331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003910485", 
              "https://doi.org/10.1038/nature08138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003910485", 
              "https://doi.org/10.1038/nature08138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth1089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003969366", 
              "https://doi.org/10.1038/nmeth1089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.18.1.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004644354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1004081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005794652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007004360", 
              "https://doi.org/10.1038/nature04193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007004360", 
              "https://doi.org/10.1038/nature04193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01265-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008684515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2012.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009074101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5453.664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009295156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1209126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009514309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2011.06220.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009725261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2009.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011020668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011334518", 
              "https://doi.org/10.1038/ni1347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011334518", 
              "https://doi.org/10.1038/ni1347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012209674", 
              "https://doi.org/10.1038/nature04734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012209674", 
              "https://doi.org/10.1038/nature04734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012209674", 
              "https://doi.org/10.1038/nature04734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2013.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012859224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2008.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013322900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2008.126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015039534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015293498", 
              "https://doi.org/10.1038/nature10719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016015496", 
              "https://doi.org/10.1038/nature05732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.11.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016295820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7310019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016411836", 
              "https://doi.org/10.1038/sj.cr.7310019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7310019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016411836", 
              "https://doi.org/10.1038/sj.cr.7310019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2013.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017005864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12192-012-0346-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017379684", 
              "https://doi.org/10.1007/s12192-012-0346-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283025ed4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018849333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0b013e3283025ed4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018849333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.05073-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019003836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00583-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019077225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diacare.27.3.813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019161418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1231143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019873131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.11.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021800213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1132998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023018481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2012.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023527609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023590081", 
              "https://doi.org/10.1038/ni.1815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.10.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026886470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201592586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030108901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2015.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030292768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2015.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030292768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2015.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030292768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.76.15.7453-7459.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031807816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032197443", 
              "https://doi.org/10.1038/nature12542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032695282", 
              "https://doi.org/10.1038/ni1087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032695282", 
              "https://doi.org/10.1038/ni1087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.8.5260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032921461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032984965", 
              "https://doi.org/10.1038/nature08699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032984965", 
              "https://doi.org/10.1038/nature08699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471250953.bi0819s49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033173762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034720331", 
              "https://doi.org/10.1038/nature07106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m510326200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037783115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2010.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040606833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2010.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040606833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2014.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040618299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0903748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042421750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mmbr.05015-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042998980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1005077107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045391764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2006.03.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045837952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.04.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047383113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.04.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047383113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0901646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048334007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncel.2014.00438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048527313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2008.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050977475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051223800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051273727", 
              "https://doi.org/10.1038/ni.2948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1239303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052744398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3791/51415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071424344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.172.2.747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076620721"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05", 
        "datePublishedReg": "2017-05-01", 
        "description": "Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular cofactors that regulate RIG-I signalling, we performed two global RNA interference analyses to identify both positive and negative regulatory nodes operating on the signalling pathway during virus infection. These factors were integrated with experimentally and computationally derived interactome data to build a RIG-I protein interaction network. Our analysis revealed diverse cellular processes, including the unfolded protein response, Wnt signalling and RNA metabolism, as critical cellular components governing innate responses to non-self RNA species. Importantly, we identified K-Homology Splicing Regulatory Protein (KHSRP) as a negative regulator of this pathway. We find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). Consistent with increased RIG-I antiviral signalling in the absence of KHSRP, viral replication is reduced when KHSRP expression is knocked down both in vitro and in vivo. Taken together, these data indicate that KHSRP functions as a checkpoint regulator of the innate immune response to pathogen challenge.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nmicrobiol.2017.22", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438843", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3857079", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440541", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2695907", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1052984", 
            "issn": [
              "2058-5276"
            ], 
            "name": "Nature Microbiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation", 
        "pagination": "nmicrobiol201722", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f5d9e372cdd0bef8f3b0721eb75508a4bbc1dcac5af64bd8febc3fc8cf0b9a49"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28248290"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101674869"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nmicrobiol.2017.22"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084129348"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nmicrobiol.2017.22", 
          "https://app.dimensions.ai/details/publication/pub.1084129348"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29207_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nmicrobiol201722"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nmicrobiol.2017.22'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nmicrobiol.2017.22'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nmicrobiol.2017.22'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nmicrobiol.2017.22'


     

    This table displays all metadata directly associated to this object as RDF triples.

    478 TRIPLES      21 PREDICATES      105 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nmicrobiol.2017.22 schema:about N24b94393f9cf4753aaa794203e8b582e
    2 N31c0ff28fc3a4dd6bfa2ddd86a607015
    3 N566e8163ca914c05b1e4fb3a728e827d
    4 N6fbd44c8c2ae4417893031342b36dc52
    5 N7954d99c0f1b405b8995e470b0671758
    6 N8a9f8c4802ad4cd195180ac7e4c3f75f
    7 N8b512e238fa84a2d95ce172278317755
    8 N9e32105b87a543c2ab61d551253d9b42
    9 Nbb2ca6d0d2bc4063b316bd47fe866efe
    10 Ncd7a1592d9924f00894abf1f33373dfe
    11 Nf1c6a5e5328c427ab93e6ff5828a0f59
    12 Nfe9b4b021fde4efd88dd93eebf271ea7
    13 anzsrc-for:06
    14 anzsrc-for:0601
    15 schema:author N20c5a173a97c46c790e56790ee602958
    16 schema:citation sg:pub.10.1007/s12192-012-0346-2
    17 sg:pub.10.1038/nature04193
    18 sg:pub.10.1038/nature04734
    19 sg:pub.10.1038/nature05732
    20 sg:pub.10.1038/nature07106
    21 sg:pub.10.1038/nature08138
    22 sg:pub.10.1038/nature08699
    23 sg:pub.10.1038/nature10719
    24 sg:pub.10.1038/nature12542
    25 sg:pub.10.1038/ni.1815
    26 sg:pub.10.1038/ni.2948
    27 sg:pub.10.1038/ni1087
    28 sg:pub.10.1038/ni1347
    29 sg:pub.10.1038/nmeth1089
    30 sg:pub.10.1038/nprot.2013.143
    31 sg:pub.10.1038/sj.cr.7310019
    32 sg:pub.10.1186/1743-422x-3-63
    33 https://doi.org/10.1002/0471250953.bi0819s49
    34 https://doi.org/10.1016/j.cell.2009.04.042
    35 https://doi.org/10.1016/j.chom.2009.04.006
    36 https://doi.org/10.1016/j.chom.2012.02.002
    37 https://doi.org/10.1016/j.chom.2013.03.011
    38 https://doi.org/10.1016/j.chom.2015.11.002
    39 https://doi.org/10.1016/j.coi.2014.10.005
    40 https://doi.org/10.1016/j.cyto.2008.07.011
    41 https://doi.org/10.1016/j.febslet.2004.08.071
    42 https://doi.org/10.1016/j.immuni.2011.05.003
    43 https://doi.org/10.1016/j.immuni.2012.03.025
    44 https://doi.org/10.1016/j.immuni.2012.11.018
    45 https://doi.org/10.1016/j.it.2012.05.002
    46 https://doi.org/10.1016/j.molcel.2007.10.032
    47 https://doi.org/10.1016/j.molcel.2007.11.028
    48 https://doi.org/10.1016/j.virol.2006.03.022
    49 https://doi.org/10.1016/j.ymeth.2010.08.007
    50 https://doi.org/10.1016/s0960-9822(00)00583-2
    51 https://doi.org/10.1016/s0960-9822(01)00487-0
    52 https://doi.org/10.1038/emboj.2008.126
    53 https://doi.org/10.1038/embor.2008.136
    54 https://doi.org/10.1038/embor.2013.102
    55 https://doi.org/10.1073/pnas.1005077107
    56 https://doi.org/10.1074/jbc.m510326200
    57 https://doi.org/10.1089/jir.2013.0143
    58 https://doi.org/10.1097/bor.0b013e3283025ed4
    59 https://doi.org/10.1101/gr.1239303
    60 https://doi.org/10.1111/j.1749-6632.2011.06220.x
    61 https://doi.org/10.1126/science.1132998
    62 https://doi.org/10.1126/science.1209126
    63 https://doi.org/10.1126/science.1231143
    64 https://doi.org/10.1126/science.287.5453.664
    65 https://doi.org/10.1128/jvi.01258-12
    66 https://doi.org/10.1128/jvi.01265-06
    67 https://doi.org/10.1128/jvi.76.15.7453-7459.2002
    68 https://doi.org/10.1128/mcb.05073-11
    69 https://doi.org/10.1128/mmbr.05015-11
    70 https://doi.org/10.1146/annurev.immunol.18.1.143
    71 https://doi.org/10.1371/journal.ppat.1004081
    72 https://doi.org/10.15252/embj.201592586
    73 https://doi.org/10.2337/diacare.27.3.813
    74 https://doi.org/10.3389/fncel.2014.00438
    75 https://doi.org/10.3791/51415
    76 https://doi.org/10.4049/jimmunol.0901646
    77 https://doi.org/10.4049/jimmunol.0903748
    78 https://doi.org/10.4049/jimmunol.172.2.747
    79 https://doi.org/10.4049/jimmunol.175.8.5260
    80 schema:datePublished 2017-05
    81 schema:datePublishedReg 2017-05-01
    82 schema:description Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular cofactors that regulate RIG-I signalling, we performed two global RNA interference analyses to identify both positive and negative regulatory nodes operating on the signalling pathway during virus infection. These factors were integrated with experimentally and computationally derived interactome data to build a RIG-I protein interaction network. Our analysis revealed diverse cellular processes, including the unfolded protein response, Wnt signalling and RNA metabolism, as critical cellular components governing innate responses to non-self RNA species. Importantly, we identified K-Homology Splicing Regulatory Protein (KHSRP) as a negative regulator of this pathway. We find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). Consistent with increased RIG-I antiviral signalling in the absence of KHSRP, viral replication is reduced when KHSRP expression is knocked down both in vitro and in vivo. Taken together, these data indicate that KHSRP functions as a checkpoint regulator of the innate immune response to pathogen challenge.
    83 schema:genre research_article
    84 schema:inLanguage en
    85 schema:isAccessibleForFree true
    86 schema:isPartOf N476d95e2ba8649a89f78e204e9c25c1c
    87 N94c7f729c7464c29acec2abe6d3114b7
    88 sg:journal.1052984
    89 schema:name Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation
    90 schema:pagination nmicrobiol201722
    91 schema:productId N1f5d481bc3ef4f81af9842f5f173aa0d
    92 N4c9aedf5dd584ba3ba8f3734dcc944aa
    93 N53965cc243c6477dae1432b5ea07a4ee
    94 N5ecf52c81350441e908a16d58d555608
    95 Nd06cdbaf9b1d4296a649a0ab76cbbfaa
    96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129348
    97 https://doi.org/10.1038/nmicrobiol.2017.22
    98 schema:sdDatePublished 2019-04-11T11:55
    99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    100 schema:sdPublisher Nfc36202cd904469da6328de8b329225e
    101 schema:url http://www.nature.com/articles/nmicrobiol201722
    102 sgo:license sg:explorer/license/
    103 sgo:sdDataset articles
    104 rdf:type schema:ScholarlyArticle
    105 N198a0fcf36064fc58e27161c373aaa82 rdf:first sg:person.012673345265.90
    106 rdf:rest N6b53ae347f774059bc660d7015e253df
    107 N1f5d481bc3ef4f81af9842f5f173aa0d schema:name doi
    108 schema:value 10.1038/nmicrobiol.2017.22
    109 rdf:type schema:PropertyValue
    110 N20c5a173a97c46c790e56790ee602958 rdf:first sg:person.01032051536.52
    111 rdf:rest N4a751667297d4c6596519b6db099e1a2
    112 N24b94393f9cf4753aaa794203e8b582e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name HEK293 Cells
    114 rdf:type schema:DefinedTerm
    115 N26c27dfbb6324eb1a6ed6bbf4aed9bde rdf:first sg:person.01264246230.11
    116 rdf:rest Neb08c47494d1417b90a23e38ccc13d55
    117 N31c0ff28fc3a4dd6bfa2ddd86a607015 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Humans
    119 rdf:type schema:DefinedTerm
    120 N345a54fb60654a06b15b5092df2eb7e8 rdf:first sg:person.01062036517.84
    121 rdf:rest N198a0fcf36064fc58e27161c373aaa82
    122 N370d2761a9ff4cd1b7736bf53d80fa5a rdf:first sg:person.01333444233.21
    123 rdf:rest N54113f7785144cfbbf7e7ca66bdc8aab
    124 N4225de5af0d448ada3278df9900b7e7e rdf:first sg:person.01102561516.89
    125 rdf:rest Nb811cce144894c549660a6df7e641fa8
    126 N476d95e2ba8649a89f78e204e9c25c1c schema:volumeNumber 2
    127 rdf:type schema:PublicationVolume
    128 N4a751667297d4c6596519b6db099e1a2 rdf:first sg:person.01162655176.14
    129 rdf:rest N4225de5af0d448ada3278df9900b7e7e
    130 N4c9aedf5dd584ba3ba8f3734dcc944aa schema:name readcube_id
    131 schema:value f5d9e372cdd0bef8f3b0721eb75508a4bbc1dcac5af64bd8febc3fc8cf0b9a49
    132 rdf:type schema:PropertyValue
    133 N53965cc243c6477dae1432b5ea07a4ee schema:name nlm_unique_id
    134 schema:value 101674869
    135 rdf:type schema:PropertyValue
    136 N54113f7785144cfbbf7e7ca66bdc8aab rdf:first sg:person.01205153066.16
    137 rdf:rest rdf:nil
    138 N566e8163ca914c05b1e4fb3a728e827d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Trans-Activators
    140 rdf:type schema:DefinedTerm
    141 N5ecf52c81350441e908a16d58d555608 schema:name pubmed_id
    142 schema:value 28248290
    143 rdf:type schema:PropertyValue
    144 N6420ac3547c640df9fbb1260c6ddeb57 rdf:first sg:person.01317250141.29
    145 rdf:rest N7bb98c233e2a4aa594529821a1320648
    146 N6b53ae347f774059bc660d7015e253df rdf:first sg:person.0662322003.56
    147 rdf:rest N26c27dfbb6324eb1a6ed6bbf4aed9bde
    148 N6fbd44c8c2ae4417893031342b36dc52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Immunity, Innate
    150 rdf:type schema:DefinedTerm
    151 N7954d99c0f1b405b8995e470b0671758 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name RNA, Viral
    153 rdf:type schema:DefinedTerm
    154 N7bb98c233e2a4aa594529821a1320648 rdf:first sg:person.01175654043.83
    155 rdf:rest N345a54fb60654a06b15b5092df2eb7e8
    156 N841f92e598784edbb80a26d333d89e85 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    157 schema:familyName Galvez
    158 schema:givenName Felipe
    159 rdf:type schema:Person
    160 N8a9f8c4802ad4cd195180ac7e4c3f75f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Protein Binding
    162 rdf:type schema:DefinedTerm
    163 N8b512e238fa84a2d95ce172278317755 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Influenza A Virus, H1N1 Subtype
    165 rdf:type schema:DefinedTerm
    166 N94c7f729c7464c29acec2abe6d3114b7 schema:issueNumber 5
    167 rdf:type schema:PublicationIssue
    168 N9601e01d84bb471ba48098598d41ea50 rdf:first sg:person.0671716101.23
    169 rdf:rest Nbf6fadadbe8441a7bceb641cc9d9ab4c
    170 N986e4602f3ef4e71b6448d95656d35c6 rdf:first sg:person.0764674043.81
    171 rdf:rest Nc779ddc2eb544f31aa63a1581cf4a134
    172 N9e32105b87a543c2ab61d551253d9b42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Signal Transduction
    174 rdf:type schema:DefinedTerm
    175 Nb811cce144894c549660a6df7e641fa8 rdf:first N841f92e598784edbb80a26d333d89e85
    176 rdf:rest N6420ac3547c640df9fbb1260c6ddeb57
    177 Nbb2ca6d0d2bc4063b316bd47fe866efe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name RNA-Binding Proteins
    179 rdf:type schema:DefinedTerm
    180 Nbf6fadadbe8441a7bceb641cc9d9ab4c rdf:first sg:person.01121140573.18
    181 rdf:rest Ne3d07664858d4737bac2dbc547e6ac39
    182 Nc779ddc2eb544f31aa63a1581cf4a134 rdf:first sg:person.0613100042.95
    183 rdf:rest Nd17e690b0d6f4045bdf6f981fb21d5fc
    184 Ncd7a1592d9924f00894abf1f33373dfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Protein Interaction Mapping
    186 rdf:type schema:DefinedTerm
    187 Nd06cdbaf9b1d4296a649a0ab76cbbfaa schema:name dimensions_id
    188 schema:value pub.1084129348
    189 rdf:type schema:PropertyValue
    190 Nd17e690b0d6f4045bdf6f981fb21d5fc rdf:first sg:person.01370061066.45
    191 rdf:rest N370d2761a9ff4cd1b7736bf53d80fa5a
    192 Ne3d07664858d4737bac2dbc547e6ac39 rdf:first sg:person.01235367173.34
    193 rdf:rest N986e4602f3ef4e71b6448d95656d35c6
    194 Neb08c47494d1417b90a23e38ccc13d55 rdf:first sg:person.01073751341.59
    195 rdf:rest N9601e01d84bb471ba48098598d41ea50
    196 Nf1c6a5e5328c427ab93e6ff5828a0f59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Protein Interaction Maps
    198 rdf:type schema:DefinedTerm
    199 Nfc36202cd904469da6328de8b329225e schema:name Springer Nature - SN SciGraph project
    200 rdf:type schema:Organization
    201 Nfe9b4b021fde4efd88dd93eebf271ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name DEAD Box Protein 58
    203 rdf:type schema:DefinedTerm
    204 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Biological Sciences
    206 rdf:type schema:DefinedTerm
    207 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Biochemistry and Cell Biology
    209 rdf:type schema:DefinedTerm
    210 sg:grant.2438843 http://pending.schema.org/fundedItem sg:pub.10.1038/nmicrobiol.2017.22
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.2440541 http://pending.schema.org/fundedItem sg:pub.10.1038/nmicrobiol.2017.22
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.2695907 http://pending.schema.org/fundedItem sg:pub.10.1038/nmicrobiol.2017.22
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.3857079 http://pending.schema.org/fundedItem sg:pub.10.1038/nmicrobiol.2017.22
    217 rdf:type schema:MonetaryGrant
    218 sg:journal.1052984 schema:issn 2058-5276
    219 schema:name Nature Microbiology
    220 rdf:type schema:Periodical
    221 sg:person.01032051536.52 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    222 schema:familyName Soonthornvacharin
    223 schema:givenName Stephen
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032051536.52
    225 rdf:type schema:Person
    226 sg:person.01062036517.84 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
    227 schema:familyName Balasubramaniam
    228 schema:givenName Vinod R. M. T.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062036517.84
    230 rdf:type schema:Person
    231 sg:person.01073751341.59 schema:affiliation https://www.grid.ac/institutes/grid.4391.f
    232 schema:familyName Stein
    233 schema:givenName David A.
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073751341.59
    235 rdf:type schema:Person
    236 sg:person.01102561516.89 schema:affiliation https://www.grid.ac/institutes/grid.418185.1
    237 schema:familyName Zhou
    238 schema:givenName Yingyao
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102561516.89
    240 rdf:type schema:Person
    241 sg:person.01121140573.18 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    242 schema:familyName De Jesus
    243 schema:givenName Paul D.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121140573.18
    245 rdf:type schema:Person
    246 sg:person.01162655176.14 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    247 schema:familyName Rodriguez-Frandsen
    248 schema:givenName Ariel
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162655176.14
    250 rdf:type schema:Person
    251 sg:person.01175654043.83 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
    252 schema:familyName Tripathi
    253 schema:givenName Shashank
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175654043.83
    255 rdf:type schema:Person
    256 sg:person.01205153066.16 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    257 schema:familyName Chanda
    258 schema:givenName Sumit K.
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205153066.16
    260 rdf:type schema:Person
    261 sg:person.01235367173.34 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    262 schema:familyName Nguyen
    263 schema:givenName Quy
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235367173.34
    265 rdf:type schema:Person
    266 sg:person.01264246230.11 schema:affiliation https://www.grid.ac/institutes/grid.4391.f
    267 schema:familyName Moulton
    268 schema:givenName Hong
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264246230.11
    270 rdf:type schema:Person
    271 sg:person.012673345265.90 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    272 schema:familyName Inoue
    273 schema:givenName Atsushi
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012673345265.90
    275 rdf:type schema:Person
    276 sg:person.01317250141.29 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    277 schema:familyName Huffmaster
    278 schema:givenName Nicholas J.
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317250141.29
    280 rdf:type schema:Person
    281 sg:person.01333444233.21 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    282 schema:familyName Yoh
    283 schema:givenName Sunnie M.
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333444233.21
    285 rdf:type schema:Person
    286 sg:person.01370061066.45 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
    287 schema:familyName García-Sastre
    288 schema:givenName Adolfo
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370061066.45
    290 rdf:type schema:Person
    291 sg:person.0613100042.95 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    292 schema:familyName Krogan
    293 schema:givenName Nevan J.
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613100042.95
    295 rdf:type schema:Person
    296 sg:person.0662322003.56 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
    297 schema:familyName de Castro
    298 schema:givenName Elisa
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662322003.56
    300 rdf:type schema:Person
    301 sg:person.0671716101.23 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
    302 schema:familyName Sánchez-Aparicio
    303 schema:givenName María Teresa
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671716101.23
    305 rdf:type schema:Person
    306 sg:person.0764674043.81 schema:affiliation https://www.grid.ac/institutes/grid.425396.f
    307 schema:familyName König
    308 schema:givenName Renate
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764674043.81
    310 rdf:type schema:Person
    311 sg:pub.10.1007/s12192-012-0346-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017379684
    312 https://doi.org/10.1007/s12192-012-0346-2
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nature04193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007004360
    315 https://doi.org/10.1038/nature04193
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/nature04734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012209674
    318 https://doi.org/10.1038/nature04734
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nature05732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016015496
    321 https://doi.org/10.1038/nature05732
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/nature07106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034720331
    324 https://doi.org/10.1038/nature07106
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/nature08138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003910485
    327 https://doi.org/10.1038/nature08138
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/nature08699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032984965
    330 https://doi.org/10.1038/nature08699
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/nature10719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015293498
    333 https://doi.org/10.1038/nature10719
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/nature12542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032197443
    336 https://doi.org/10.1038/nature12542
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/ni.1815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023590081
    339 https://doi.org/10.1038/ni.1815
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/ni.2948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051273727
    342 https://doi.org/10.1038/ni.2948
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/ni1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032695282
    345 https://doi.org/10.1038/ni1087
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/ni1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011334518
    348 https://doi.org/10.1038/ni1347
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nmeth1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003969366
    351 https://doi.org/10.1038/nmeth1089
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    354 https://doi.org/10.1038/nprot.2013.143
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/sj.cr.7310019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016411836
    357 https://doi.org/10.1038/sj.cr.7310019
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1186/1743-422x-3-63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000911842
    360 https://doi.org/10.1186/1743-422x-3-63
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1002/0471250953.bi0819s49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033173762
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/j.cell.2009.04.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047383113
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/j.chom.2009.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011020668
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/j.chom.2012.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009074101
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/j.chom.2013.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017005864
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/j.chom.2015.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030292768
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/j.coi.2014.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040618299
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/j.cyto.2008.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013322900
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/j.febslet.2004.08.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003770331
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/j.immuni.2011.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002914189
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/j.immuni.2012.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051223800
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.immuni.2012.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021800213
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/j.it.2012.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023527609
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/j.molcel.2007.10.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026886470
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/j.molcel.2007.11.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016295820
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/j.virol.2006.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045837952
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/j.ymeth.2010.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040606833
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/s0960-9822(00)00583-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019077225
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/s0960-9822(01)00487-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000785187
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1038/emboj.2008.126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015039534
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1038/embor.2008.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050977475
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1038/embor.2013.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012859224
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1073/pnas.1005077107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045391764
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1074/jbc.m510326200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037783115
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1089/jir.2013.0143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003453275
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1097/bor.0b013e3283025ed4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018849333
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1101/gr.1239303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052744398
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1111/j.1749-6632.2011.06220.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009725261
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1126/science.1132998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023018481
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1126/science.1209126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009514309
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1126/science.1231143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019873131
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1126/science.287.5453.664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009295156
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1128/jvi.01258-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002166598
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1128/jvi.01265-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008684515
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1128/jvi.76.15.7453-7459.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031807816
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1128/mcb.05073-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019003836
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1128/mmbr.05015-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042998980
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1146/annurev.immunol.18.1.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004644354
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1371/journal.ppat.1004081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005794652
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.15252/embj.201592586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030108901
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.2337/diacare.27.3.813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019161418
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.3389/fncel.2014.00438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048527313
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.3791/51415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071424344
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.4049/jimmunol.0901646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048334007
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.4049/jimmunol.0903748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042421750
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.4049/jimmunol.172.2.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076620721
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.4049/jimmunol.175.8.5260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921461
    455 rdf:type schema:CreativeWork
    456 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
    457 schema:name Department of Cellular and Molecular Pharmacology, University of California San Francisco, 1700 4th Street, Byers Hall 308D, Box 2530, San Francisco, California 94158, USA
    458 rdf:type schema:Organization
    459 https://www.grid.ac/institutes/grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation
    460 schema:name Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA
    461 rdf:type schema:Organization
    462 https://www.grid.ac/institutes/grid.425396.f schema:alternateName Paul Ehrlich Institut
    463 schema:name Host-Pathogen-Interactions, Paul-Ehrlich-Institute, German Center for Infection Research (DZIF), Paul-Ehrlich-Straße 51–59, 63225 Langen, Germany
    464 Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    465 rdf:type schema:Organization
    466 https://www.grid.ac/institutes/grid.4391.f schema:alternateName Oregon State University
    467 schema:name Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, 450 SW 30th Street, Oregon 97331, USA
    468 rdf:type schema:Organization
    469 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
    470 schema:name Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    471 Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    472 The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA
    473 rdf:type schema:Organization
    474 https://www.grid.ac/institutes/grid.59734.3c schema:alternateName Icahn School of Medicine at Mount Sinai
    475 schema:name Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA
    476 Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA
    477 Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA
    478 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...