Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-22

AUTHORS

Alexandra E. Livanos, Thomas U. Greiner, Pajau Vangay, Wimal Pathmasiri, Delisha Stewart, Susan McRitchie, Huilin Li, Jennifer Chung, Jiho Sohn, Sara Kim, Zhan Gao, Cecily Barber, Joanne Kim, Sandy Ng, Arlin B. Rogers, Susan Sumner, Xue-Song Zhang, Ken Cadwell, Dan Knights, Alexander Alekseyenko, Fredrik Bäckhed, Martin J. Blaser

ABSTRACT

The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been increasing substantially in recent decades, we hypothesized that early-life antibiotic use alters gut microbiota, which predisposes to disease. Using non-obese diabetic mice that are genetically susceptible to T1D, we examined the effects of exposure to either continuous low-dose antibiotics or pulsed therapeutic antibiotics (PAT) early in life, mimicking childhood exposures. We found that in mice receiving PAT, T1D incidence was significantly higher, and microbial community composition and structure differed compared with controls. In pre-diabetic male PAT mice, the intestinal lamina propria had lower Th17 and Treg proportions and intestinal SAA expression than in controls, suggesting key roles in transducing the altered microbiota signals. PAT affected microbial lipid metabolism and host cholesterol biosynthetic gene expression. These findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice. More... »

PAGES

16140

References to SciGraph publications

  • 2010-02-02. Th17 Cytokines and the Gut Mucosal Barrier in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2002-11. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease in NATURE
  • 2011-12-01. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2001-10. Random Forests in MACHINE LEARNING
  • 2012-03-08. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-02-29. Integrating metabolomic signatures and psychosocial parameters in responsivity to an immersion treatment model for adolescent obesity in METABOLOMICS
  • 2012-05-09. Human gut microbiome viewed across age and geography in NATURE
  • 2007-10-25. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts in NATURE PROTOCOLS
  • 2013-08-25. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences in NATURE BIOTECHNOLOGY
  • 2010-02-07. Metabolomics of urine for the assessment of microvesicular lipid accumulation in the liver following isoniazid exposure in METABOLOMICS
  • 2008-12-18. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2008-02-22. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies in DIABETOLOGIA
  • 2015-08-14. Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-01-17. Metabolomics of brain and reproductive organs: characterizing the impact of gestational exposure to butylbenzyl phthalate on dams and resultant offspring in METABOLOMICS
  • 2014-07-23. Diabetes associated metabolomic perturbations in NOD mice in METABOLOMICS
  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2013-11-13. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells in NATURE
  • 2015-06-30. Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment in NATURE COMMUNICATIONS
  • 2010-11-25. Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases in NATURE REVIEWS IMMUNOLOGY
  • 2011-04-06. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease in NATURE
  • 2008-09-21. Innate immunity and intestinal microbiota in the development of Type 1 diabetes in NATURE
  • 2011-06-24. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2012-05-10. Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse in DIABETOLOGIA
  • 2010-07-08. Toward defining the autoimmune microbiome for type 1 diabetes in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2006-10-07. Increased intestinal permeability precedes clinical onset of type 1 diabetes in DIABETOLOGIA
  • 2012-08-22. Antibiotics in early life alter the murine colonic microbiome and adiposity in NATURE
  • Journal

    TITLE

    Nature Microbiology

    ISSUE

    11

    VOLUME

    1

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmicrobiol.2016.140

    DOI

    http://dx.doi.org/10.1038/nmicrobiol.2016.140

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022996683

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27782139


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