Interrogation of genomes by molecular copy-number counting (MCC) View Full Text


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Article Info

DATE

2006-06

AUTHORS

Alan Forster, Angelika Daser, Grace Chung, Louise Sparrow, Madan Thangavelu, Paul H Dear, Richard Pannell, Terence H Rabbitts

ABSTRACT

Human cancers and some congenital traits are characterized by cytogenetic aberrations including translocations, amplifications, duplications or deletions that can involve gain or loss of genetic material. We have developed a simple method to precisely delineate such regions with known or cryptic genomic alterations. Molecular copy-number counting (MCC) uses PCR to interrogate miniscule amounts of genomic DNA and allows progressive delineation of DNA content to within a few hundred base pairs of a genomic alteration. As an example, we have located the junctions of a recurrent nonreciprocal translocation between chromosomes 3 and 5 in human renal cell carcinoma, facilitating cloning of the breakpoint without recourse to genomic libraries. The analysis also revealed additional cryptic chromosomal changes close to the translocation junction. MCC is a fast and flexible method for characterizing a wide range of chromosomal aberrations. More... »

PAGES

447

Journal

TITLE

Nature Methods

ISSUE

6

VOLUME

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth880

DOI

http://dx.doi.org/10.1038/nmeth880

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002804833

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16721378


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