BEAMing up for detection and quantification of rare sequence variants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-02

AUTHORS

Meng Li, Frank Diehl, Devin Dressman, Bert Vogelstein, Kenneth W Kinzler

ABSTRACT

BEAMing allows the one-to-one conversion of a population of DNA fragments into a population of beads. We used rolling circle amplification to increase the number of copies bound to such beads by more than 100-fold. This allowed enumeration of mutant and wild-type sequences even when they were present at ratios less than 1:10,000 and was sensitive enough to directly quantify the error rate of DNA polymerases used for PCR. More... »

PAGES

95-97

Journal

TITLE

Nature Methods

ISSUE

2

VOLUME

3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth850

DOI

http://dx.doi.org/10.1038/nmeth850

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017857571

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16432518


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