Whole-genome genotyping with the single-base extension assay View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

Frank J Steemers, Weihua Chang, Grace Lee, David L Barker, Richard Shen, Kevin L Gunderson

ABSTRACT

We describe an efficient, accurate and robust whole-genome genotyping (WGG) assay based on a two-color, single-base extension (SBE), single-nucleotide polymorphism (SNP)-scoring step. We report genotyping results for biallelic International HapMap quality control (QC) SNPs using a single probe per locus. We show scalability, throughput and accuracy of the system by resequencing homozygous loci from our 100k Human-1 Genotyping BeadChip. More... »

PAGES

31-33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth842

DOI

http://dx.doi.org/10.1038/nmeth842

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031918541

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16369550


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