Microarray-based genomic selection for high-throughput resequencing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-11

AUTHORS

David T Okou, Karyn Meltz Steinberg, Christina Middle, David J Cutler, Thomas J Albert, Michael E Zwick

ABSTRACT

We developed a general method, microarray-based genomic selection (MGS), capable of selecting and enriching targeted sequences from complex eukaryotic genomes without the repeat blocking steps necessary for bacterial artificial chromosome (BAC)-based genomic selection. We demonstrate that large human genomic regions, on the order of hundreds of kilobases, can be enriched and resequenced with resequencing arrays. MGS, when combined with a next-generation resequencing technology, can enable large-scale resequencing in single-investigator laboratories. More... »

PAGES

907-909

Journal

TITLE

Nature Methods

ISSUE

11

VOLUME

4

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  • Method And Systems For Enrichment Of Target Genomic Sequences
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  • Compositions And Methods For Targeted Nucleic Acid Sequence Selection And Amplification
  • Multiplex Capture Of Nucleic Acids
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmeth1109

    DOI

    http://dx.doi.org/10.1038/nmeth1109

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009647980

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17934469


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