MALDI imaging mass spectrometry: molecular snapshots of biochemical systems View Full Text


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Article Info

DATE

2007-10

AUTHORS

Dale S Cornett, Michelle L Reyzer, Pierre Chaurand, Richard M Caprioli

ABSTRACT

Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is emerging as a powerful tool for investigating the distribution of molecules within biological systems through the direct analysis of thin tissue sections. Unique among imaging methods, MALDI-IMS can determine the distribution of hundreds of unknown compounds in a single measurement. We discuss the current state of the art of MALDI-IMS along with some recent applications and technological developments that illustrate not only its current capabilities but also the future potential of the technique to provide a better understanding of the underlying molecular mechanisms of biological processes. More... »

PAGES

828

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth1094

DOI

http://dx.doi.org/10.1038/nmeth1094

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026462539

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17901873


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