The development of a bioengineered organ germ method View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03

AUTHORS

Kazuhisa Nakao, Ritsuko Morita, Yasumitsu Saji, Kentaro Ishida, Yusuke Tomita, Miho Ogawa, Masahiro Saitoh, Yasuhiro Tomooka, Takashi Tsuji

ABSTRACT

To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies. More... »

PAGES

227-230

References to SciGraph publications

  • 1999-04. Tissue engineering: the challenges ahead. in SCIENTIFIC AMERICAN
  • 2004-07. The cutting-edge of mammalian development; how the embryo makes teeth in NATURE REVIEWS GENETICS
  • 2005-08. Test-Tube Teeth in SCIENTIFIC AMERICAN
  • Journal

    TITLE

    Nature Methods

    ISSUE

    3

    VOLUME

    4

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmeth1012

    DOI

    http://dx.doi.org/10.1038/nmeth1012

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016290026

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17322892


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