Ontology type: schema:ScholarlyArticle
2017-03
AUTHORSMichele Chirichella, Simonetta Lisi, Marco Fantini, Martina Goracci, Mariantonietta Calvello, Rossella Brandi, Ivan Arisi, Mara D'Onofrio, Cristina Di Primio, Antonino Cattaneo
ABSTRACTThe ability to selectively interfere with post-translationally modified proteins would have many biological and therapeutic applications. However, post-translational modifications cannot be selectively targeted by nucleic-acid-based interference approaches. Here we describe post-translational intracellular silencing antibody technology (PISA), a method for selecting intrabodies against post-translationally modified proteins. We demonstrate our method by generating intrabodies against native acetylated proteins and showing functional interference in living cells. More... »
PAGES279-282
http://scigraph.springernature.com/pub.10.1038/nmeth.4144
DOIhttp://dx.doi.org/10.1038/nmeth.4144
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