Post-translational selective intracellular silencing of acetylated proteins with de novo selected intrabodies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Michele Chirichella, Simonetta Lisi, Marco Fantini, Martina Goracci, Mariantonietta Calvello, Rossella Brandi, Ivan Arisi, Mara D'Onofrio, Cristina Di Primio, Antonino Cattaneo

ABSTRACT

The ability to selectively interfere with post-translationally modified proteins would have many biological and therapeutic applications. However, post-translational modifications cannot be selectively targeted by nucleic-acid-based interference approaches. Here we describe post-translational intracellular silencing antibody technology (PISA), a method for selecting intrabodies against post-translationally modified proteins. We demonstrate our method by generating intrabodies against native acetylated proteins and showing functional interference in living cells. More... »

PAGES

279-282

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth.4144

DOI

http://dx.doi.org/10.1038/nmeth.4144

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023347132

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28092690


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