rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10

AUTHORS

Chun Kit Kwok, Giovanni Marsico, Aleksandr B Sahakyan, Vicki S Chambers, Shankar Balasubramanian

ABSTRACT

We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling with next-generation sequencing. Using rG4-seq on polyadenylated-enriched HeLa RNA, we generated a global in vitro map of thousands of canonical and noncanonical rG4 structures. We characterize rG4 formation relative to cytosine content and alternative RNA structure stability, uncover rG4-dependent differences in RNA folding and show evolutionarily conserved enrichment in transcripts mediating RNA processing and stability. More... »

PAGES

841-844

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth.3965

DOI

http://dx.doi.org/10.1038/nmeth.3965

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043561156

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27571552


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