Engineering an allosteric transcription factor to respond to new ligands View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-21

AUTHORS

Noah D Taylor, Alexander S Garruss, Rocco Moretti, Sum Chan, Mark A Arbing, Duilio Cascio, Jameson K Rogers, Farren J Isaacs, Sriram Kosuri, David Baker, Stanley Fields, George M Church, Srivatsan Raman

ABSTRACT

The combination of computational protein design and single-site saturation mutagenesis enables engineering of allosteric transcription factors to respond to new small molecules.

PAGES

177-183

Journal

TITLE

Nature Methods

ISSUE

2

VOLUME

13

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth.3696

DOI

http://dx.doi.org/10.1038/nmeth.3696

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011151909

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26689263


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