Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

Adam D Ewing, Kathleen E Houlahan, Yin Hu, Kyle Ellrott, Cristian Caloian, Takafumi N Yamaguchi, J Christopher Bare, Christine P'ng, Daryl Waggott, Veronica Y Sabelnykova, ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Liu Xi, Ninad Dewal, Yu Fan, Wenyi Wang, David Wheeler, Andreas Wilm, Grace Hui Ting, Chenhao Li, Denis Bertrand, Niranjan Nagarajan, Qing-Rong Chen, Chih-Hao Hsu, Ying Hu, Chunhua Yan, Warren Kibbe, Daoud Meerzaman, Kristian Cibulskis, Mara Rosenberg, Louis Bergelson, Adam Kiezun, Amie Radenbaugh, Anne-Sophie Sertier, Anthony Ferrari, Laurie Tonton, Kunal Bhutani, Nancy F Hansen, Difei Wang, Lei Song, Zhongwu Lai, Yang Liao, Wei Shi, José Carbonell-Caballero, Joaquín Dopazo, Cheryl C K Lau, Justin Guinney, Michael R Kellen, Thea C Norman, David Haussler, Stephen H Friend, Gustavo Stolovitzky, Adam A Margolin, Joshua M Stuart, Paul C Boutros

ABSTRACT

The detection of somatic mutations from cancer genome sequences is key to understanding the genetic basis of disease progression, patient survival and response to therapy. Benchmarking is needed for tool assessment and improvement but is complicated by a lack of gold standards, by extensive resource requirements and by difficulties in sharing personal genomic information. To resolve these issues, we launched the ICGC-TCGA DREAM Somatic Mutation Calling Challenge, a crowdsourced benchmark of somatic mutation detection algorithms. Here we report the BAMSurgeon tool for simulating cancer genomes and the results of 248 analyses of three in silico tumors created with it. Different algorithms exhibit characteristic error profiles, and, intriguingly, false positives show a trinucleotide profile very similar to one found in human tumors. Although the three simulated tumors differ in sequence contamination (deviation from normal cell sequence) and in subclonality, an ensemble of pipelines outperforms the best individual pipeline in all cases. BAMSurgeon is available at https://github.com/adamewing/bamsurgeon/. More... »

PAGES

623-630

References to SciGraph publications

  • 2013-12. Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing in GENOME MEDICINE
  • 2011-12. Identification and correction of systematic error in high-throughput sequence data in BMC BIOINFORMATICS
  • 2013-03. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples in NATURE BIOTECHNOLOGY
  • 2010-06. Trial watch: Adaptive BATTLE trial uses biomarkers to guide lung cancer treatment in NATURE REVIEWS DRUG DISCOVERY
  • 2008-12. Conditional variable importance for random forests in BMC BIOINFORMATICS
  • 2013-05-01. Integrated genomic characterization of endometrial carcinoma in NATURE
  • 2013-10. Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas in NATURE GENETICS
  • 2013-06. Parallel comparison of Illumina RNA-Seq and Affymetrix microarray platforms on transcriptomic profiles generated from 5-aza-deoxy-cytidine treated HT-29 colon cancer cells and simulated datasets in BMC BIOINFORMATICS
  • 2014-10. SeqControl: process control for DNA sequencing in NATURE METHODS
  • 2013-10. Emerging landscape of oncogenic signatures across human cancers in NATURE GENETICS
  • 2013-02. Protein function prediction by massive integration of evolutionary analyses and multiple data sources in BMC BIOINFORMATICS
  • 2007-12. Bias in random forest variable importance measures: Illustrations, sources and a solution in BMC BIOINFORMATICS
  • 2014-04. Global optimization of somatic variant identification in cancer genomes with a global community challenge in NATURE GENETICS
  • 2014-09. Toward better benchmarking: challenge-based methods assessment in cancer genomics in GENOME BIOLOGY
  • 2012-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • 2013-04. Discovering motifs that induce sequencing errors in BMC BIOINFORMATICS
  • 2013-12. Comparing somatic mutation-callers: beyond Venn diagrams in BMC BIOINFORMATICS
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2014-01. Discovery and saturation analysis of cancer genes across 21 tumour types in NATURE
  • 2013-08. Signatures of mutational processes in human cancer in NATURE
  • 2012-08. Wisdom of crowds for robust gene network inference in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmeth.3407

    DOI

    http://dx.doi.org/10.1038/nmeth.3407

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020099324

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25984700


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Algorithms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Benchmarking", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crowdsourcing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Queensland", 
              "id": "https://www.grid.ac/institutes/grid.1003.2", 
              "name": [
                "Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.", 
                "Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ewing", 
            "givenName": "Adam D", 
            "id": "sg:person.0667343407.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667343407.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Houlahan", 
            "givenName": "Kathleen E", 
            "id": "sg:person.01276344410.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276344410.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sage Bionetworks", 
              "id": "https://www.grid.ac/institutes/grid.430406.5", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Yin", 
            "id": "sg:person.01051552560.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051552560.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Santa Cruz", 
              "id": "https://www.grid.ac/institutes/grid.205975.c", 
              "name": [
                "Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ellrott", 
            "givenName": "Kyle", 
            "id": "sg:person.01070176346.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070176346.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caloian", 
            "givenName": "Cristian", 
            "id": "sg:person.01263725354.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263725354.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamaguchi", 
            "givenName": "Takafumi N", 
            "id": "sg:person.01042231561.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042231561.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sage Bionetworks", 
              "id": "https://www.grid.ac/institutes/grid.430406.5", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bare", 
            "givenName": "J Christopher", 
            "id": "sg:person.01071473722.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071473722.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P'ng", 
            "givenName": "Christine", 
            "id": "sg:person.01130665441.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130665441.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waggott", 
            "givenName": "Daryl", 
            "id": "sg:person.01256775602.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256775602.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sabelnykova", 
            "givenName": "Veronica Y", 
            "id": "sg:person.01176032221.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176032221.25"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "participants", 
            "givenName": "ICGC-TCGA DREAM Somatic Mutation Calling Challenge", 
            "id": "sg:person.015427326220.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015427326220.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Team Wang Wheeler HGSC, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xi", 
            "givenName": "Liu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Team Wang Wheeler HGSC, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dewal", 
            "givenName": "Ninad", 
            "id": "sg:person.0576402465.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576402465.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Team Wang Wheeler HGSC, Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fan", 
            "givenName": "Yu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Team Wang Wheeler HGSC, Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Wenyi", 
            "id": "sg:person.011121241077.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011121241077.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Team Wang Wheeler HGSC, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.", 
                "Team Wang Wheeler HGSC, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wheeler", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Institute of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.418377.e", 
              "name": [
                "Team LoFreq Somatic GIS, Genome Institute of Singapore, Computational and Systems Biology, Singapore.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilm", 
            "givenName": "Andreas", 
            "id": "sg:person.0716312730.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716312730.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Institute of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.418377.e", 
              "name": [
                "Team LoFreq Somatic GIS, Genome Institute of Singapore, Computational and Systems Biology, Singapore.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ting", 
            "givenName": "Grace Hui", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Institute of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.418377.e", 
              "name": [
                "Team LoFreq Somatic GIS, Genome Institute of Singapore, Computational and Systems Biology, Singapore.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Chenhao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Institute of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.418377.e", 
              "name": [
                "Team LoFreq Somatic GIS, Genome Institute of Singapore, Computational and Systems Biology, Singapore.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bertrand", 
            "givenName": "Denis", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Institute of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.418377.e", 
              "name": [
                "Team LoFreq Somatic GIS, Genome Institute of Singapore, Computational and Systems Biology, Singapore.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagarajan", 
            "givenName": "Niranjan", 
            "id": "sg:person.0653720306.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653720306.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Qing-Rong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hsu", 
            "givenName": "Chih-Hao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Ying", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yan", 
            "givenName": "Chunhua", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kibbe", 
            "givenName": "Warren", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meerzaman", 
            "givenName": "Daoud", 
            "id": "sg:person.013732223267.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732223267.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Team Broad, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cibulskis", 
            "givenName": "Kristian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Team Broad, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenberg", 
            "givenName": "Mara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Team Broad, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bergelson", 
            "givenName": "Louis", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Team Broad, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kiezun", 
            "givenName": "Adam", 
            "id": "sg:person.01274672135.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274672135.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Santa Cruz", 
              "id": "https://www.grid.ac/institutes/grid.205975.c", 
              "name": [
                "Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radenbaugh", 
            "givenName": "Amie", 
            "id": "sg:person.0673542511.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673542511.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre L\u00e9on B\u00e9rard", 
              "id": "https://www.grid.ac/institutes/grid.418116.b", 
              "name": [
                "Team SLC Platform, Synergie Lyon Cancer Foundation, Centre L\u00e9on B\u00e9rard, Lyon, France.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sertier", 
            "givenName": "Anne-Sophie", 
            "id": "sg:person.0765035064.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765035064.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre L\u00e9on B\u00e9rard", 
              "id": "https://www.grid.ac/institutes/grid.418116.b", 
              "name": [
                "Team SLC Platform, Synergie Lyon Cancer Foundation, Centre L\u00e9on B\u00e9rard, Lyon, France.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferrari", 
            "givenName": "Anthony", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre L\u00e9on B\u00e9rard", 
              "id": "https://www.grid.ac/institutes/grid.418116.b", 
              "name": [
                "Team SLC Platform, Synergie Lyon Cancer Foundation, Centre L\u00e9on B\u00e9rard, Lyon, France.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tonton", 
            "givenName": "Laurie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Team Virmid, Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, California, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhutani", 
            "givenName": "Kunal", 
            "id": "sg:person.01273152703.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273152703.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Team Shimmer, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hansen", 
            "givenName": "Nancy F", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Georgetown University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.411667.3", 
              "name": [
                "Team 2014, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.", 
                "Team 2014, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Difei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Georgetown University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.411667.3", 
              "name": [
                "Team 2014, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Lei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AstraZeneca (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418152.b", 
              "name": [
                "Team AstraZeneca, AstraZeneca, Waltham, Massachusetts, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lai", 
            "givenName": "Zhongwu", 
            "id": "sg:person.01005050133.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005050133.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Team WEHI-Subread, Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liao", 
            "givenName": "Yang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Team WEHI-Subread, Department of Computing and Information Systems, The University of Melbourne, Melbourne, Victoria, Australia.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shi", 
            "givenName": "Wei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Team Germmatic, Functional Genomics Node (INB) at Pr\u00edncipe Felipe Research Center (CIPF), Valencia, Spain.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carbonell-Caballero", 
            "givenName": "Jos\u00e9", 
            "id": "sg:person.0635001201.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635001201.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Team Germmatic, Functional Genomics Node (INB) at Pr\u00edncipe Felipe Research Center (CIPF), Valencia, Spain.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dopazo", 
            "givenName": "Joaqu\u00edn", 
            "id": "sg:person.0777551331.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777551331.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ontario Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.419890.d", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lau", 
            "givenName": "Cheryl C K", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sage Bionetworks", 
              "id": "https://www.grid.ac/institutes/grid.430406.5", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guinney", 
            "givenName": "Justin", 
            "id": "sg:person.011660703047.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011660703047.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sage Bionetworks", 
              "id": "https://www.grid.ac/institutes/grid.430406.5", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kellen", 
            "givenName": "Michael R", 
            "id": "sg:person.0620314676.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620314676.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sage Bionetworks", 
              "id": "https://www.grid.ac/institutes/grid.430406.5", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Norman", 
            "givenName": "Thea C", 
            "id": "sg:person.0772773367.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772773367.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Santa Cruz", 
              "id": "https://www.grid.ac/institutes/grid.205975.c", 
              "name": [
                "Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haussler", 
            "givenName": "David", 
            "id": "sg:person.01355471663.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355471663.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sage Bionetworks", 
              "id": "https://www.grid.ac/institutes/grid.430406.5", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Friend", 
            "givenName": "Stephen H", 
            "id": "sg:person.0735727565.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735727565.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IBM Research \u2013 Thomas J. Watson Research Center", 
              "id": "https://www.grid.ac/institutes/grid.481554.9", 
              "name": [
                "IBM Computational Biology Center, T.J. Watson Research Center, Yorktown Heights, New York, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stolovitzky", 
            "givenName": "Gustavo", 
            "id": "sg:person.01277712747.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277712747.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oregon Health & Science University", 
              "id": "https://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Sage Bionetworks, Seattle, Washington, USA.", 
                "Computational Biology Program, Oregon Health & Science University, Portland, Oregon, USA.", 
                "Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Margolin", 
            "givenName": "Adam A", 
            "id": "sg:person.01322400234.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322400234.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Santa Cruz", 
              "id": "https://www.grid.ac/institutes/grid.205975.c", 
              "name": [
                "Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stuart", 
            "givenName": "Joshua M", 
            "id": "sg:person.013467131537.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013467131537.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Toronto", 
              "id": "https://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.", 
                "Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.", 
                "Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.", 
                "ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boutros", 
            "givenName": "Paul C", 
            "id": "sg:person.01127752143.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127752143.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/bioinformatics/btr665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000466381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477771", 
              "https://doi.org/10.1038/nbt.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.27817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002827685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004984574", 
              "https://doi.org/10.1038/nature12113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.39.2316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006401474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006541515", 
              "https://doi.org/10.1038/nmeth.1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008270984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-14-s5-s1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013312853", 
              "https://doi.org/10.1186/1471-2105-14-s5-s1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci034160g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013785151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ci034160g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013785151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014954618", 
              "https://doi.org/10.1038/ng.2761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3006112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015623460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btr330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018404011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019307928", 
              "https://doi.org/10.1038/nbt.1754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019739342", 
              "https://doi.org/10.1038/ng.2932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-8-25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019863657", 
              "https://doi.org/10.1186/1471-2105-8-25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/kxj011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020482831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0462-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020949465", 
              "https://doi.org/10.1186/s13059-014-0462-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0462-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020949465", 
              "https://doi.org/10.1186/s13059-014-0462-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023029250", 
              "https://doi.org/10.1038/nmeth.2016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025260149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-14-189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025914035", 
              "https://doi.org/10.1186/1471-2105-14-189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-14-189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025914035", 
              "https://doi.org/10.1186/1471-2105-14-189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028554628", 
              "https://doi.org/10.1186/1471-2105-12-451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029459317", 
              "https://doi.org/10.1038/nrd3199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.22534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031722717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.22534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031722717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.107524.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032096953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gm432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033686767", 
              "https://doi.org/10.1186/gm432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036846543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036892131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-14-s9-s1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038027122", 
              "https://doi.org/10.1186/1471-2105-14-s9-s1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038266369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039045908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042870683", 
              "https://doi.org/10.1186/1471-2105-9-307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043554069", 
              "https://doi.org/10.1038/nature12912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1530509100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044620917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.04.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045709558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0111516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046668666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048811261", 
              "https://doi.org/10.1038/ng.2762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049624779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004918", 
              "https://doi.org/10.1038/nature12477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-14-s3-s1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051469122", 
              "https://doi.org/10.1186/1471-2105-14-s3-s1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052951347", 
              "https://doi.org/10.1038/nmeth.3094"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-07", 
        "datePublishedReg": "2015-07-01", 
        "description": "The detection of somatic mutations from cancer genome sequences is key to understanding the genetic basis of disease progression, patient survival and response to therapy. Benchmarking is needed for tool assessment and improvement but is complicated by a lack of gold standards, by extensive resource requirements and by difficulties in sharing personal genomic information. To resolve these issues, we launched the ICGC-TCGA DREAM Somatic Mutation Calling Challenge, a crowdsourced benchmark of somatic mutation detection algorithms. Here we report the BAMSurgeon tool for simulating cancer genomes and the results of 248 analyses of three in silico tumors created with it. Different algorithms exhibit characteristic error profiles, and, intriguingly, false positives show a trinucleotide profile very similar to one found in human tumors. Although the three simulated tumors differ in sequence contamination (deviation from normal cell sequence) and in subclonality, an ensemble of pipelines outperforms the best individual pipeline in all cases. BAMSurgeon is available at https://github.com/adamewing/bamsurgeon/. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nmeth.3407", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2482454", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2689292", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696336", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2725731", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3805122", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438826", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3860235", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1033763", 
            "issn": [
              "1548-7091", 
              "1548-7105"
            ], 
            "name": "Nature Methods", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection", 
        "pagination": "623-630", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5fc42816bcb118cb45b9080bc19c5ec7dde4dfeadd0116be6454026e28a3c011"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25984700"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101215604"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nmeth.3407"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1020099324"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nmeth.3407", 
          "https://app.dimensions.ai/details/publication/pub.1020099324"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000550.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nmeth.3407"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nmeth.3407'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nmeth.3407'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nmeth.3407'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nmeth.3407'


     

    This table displays all metadata directly associated to this object as RDF triples.

    682 TRIPLES      21 PREDICATES      77 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nmeth.3407 schema:about N02199140ee1b473bb47bd717a0c4e533
    2 N33bf7b29848c4c95973e426d3ed9496b
    3 N742fa72d072a471ba03be3b34f863a4b
    4 Nb8011c564cad415891151a0ba734bc72
    5 Ne2650e979f28458d8d344b66c86c5e9f
    6 Nf500774a5ae94691be80b075e165c4de
    7 Nf9a7386fe2c641aab3aeba1b4a261d53
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author N37b931d0386f4afa88c3f3f2aa129382
    11 schema:citation sg:pub.10.1038/nature12113
    12 sg:pub.10.1038/nature12477
    13 sg:pub.10.1038/nature12912
    14 sg:pub.10.1038/nbt.1754
    15 sg:pub.10.1038/nbt.2514
    16 sg:pub.10.1038/ng.2761
    17 sg:pub.10.1038/ng.2762
    18 sg:pub.10.1038/ng.2932
    19 sg:pub.10.1038/nmeth.1923
    20 sg:pub.10.1038/nmeth.2016
    21 sg:pub.10.1038/nmeth.3094
    22 sg:pub.10.1038/nrd3199
    23 sg:pub.10.1186/1471-2105-12-451
    24 sg:pub.10.1186/1471-2105-14-189
    25 sg:pub.10.1186/1471-2105-14-s3-s1
    26 sg:pub.10.1186/1471-2105-14-s5-s1
    27 sg:pub.10.1186/1471-2105-14-s9-s1
    28 sg:pub.10.1186/1471-2105-8-25
    29 sg:pub.10.1186/1471-2105-9-307
    30 sg:pub.10.1186/gm432
    31 sg:pub.10.1186/s13059-014-0462-7
    32 https://doi.org/10.1002/ijc.27817
    33 https://doi.org/10.1002/prot.22534
    34 https://doi.org/10.1016/j.cell.2012.04.024
    35 https://doi.org/10.1021/ci034160g
    36 https://doi.org/10.1073/pnas.1530509100
    37 https://doi.org/10.1093/bioinformatics/btp324
    38 https://doi.org/10.1093/bioinformatics/btp352
    39 https://doi.org/10.1093/bioinformatics/btp373
    40 https://doi.org/10.1093/bioinformatics/btq033
    41 https://doi.org/10.1093/bioinformatics/btq057
    42 https://doi.org/10.1093/bioinformatics/btr330
    43 https://doi.org/10.1093/bioinformatics/btr665
    44 https://doi.org/10.1093/bioinformatics/bts187
    45 https://doi.org/10.1093/bioinformatics/bts271
    46 https://doi.org/10.1093/biostatistics/kxj011
    47 https://doi.org/10.1093/nar/gkr344
    48 https://doi.org/10.1101/gr.107524.110
    49 https://doi.org/10.1126/scitranslmed.3006112
    50 https://doi.org/10.1200/jco.2011.39.2316
    51 https://doi.org/10.1371/journal.pone.0111516
    52 schema:datePublished 2015-07
    53 schema:datePublishedReg 2015-07-01
    54 schema:description The detection of somatic mutations from cancer genome sequences is key to understanding the genetic basis of disease progression, patient survival and response to therapy. Benchmarking is needed for tool assessment and improvement but is complicated by a lack of gold standards, by extensive resource requirements and by difficulties in sharing personal genomic information. To resolve these issues, we launched the ICGC-TCGA DREAM Somatic Mutation Calling Challenge, a crowdsourced benchmark of somatic mutation detection algorithms. Here we report the BAMSurgeon tool for simulating cancer genomes and the results of 248 analyses of three in silico tumors created with it. Different algorithms exhibit characteristic error profiles, and, intriguingly, false positives show a trinucleotide profile very similar to one found in human tumors. Although the three simulated tumors differ in sequence contamination (deviation from normal cell sequence) and in subclonality, an ensemble of pipelines outperforms the best individual pipeline in all cases. BAMSurgeon is available at https://github.com/adamewing/bamsurgeon/.
    55 schema:genre research_article
    56 schema:inLanguage en
    57 schema:isAccessibleForFree true
    58 schema:isPartOf N769d617495e54b32b9b1e0683eca0a63
    59 Necac959ea5474526811f10f1ff1bd517
    60 sg:journal.1033763
    61 schema:name Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection
    62 schema:pagination 623-630
    63 schema:productId N3194873d9a7a4825aa540466bad098d9
    64 N5725e7b69dc443709417d938f22a0245
    65 N9a05219c7a3c492a9aefee0df4a5a233
    66 Nb1a3f5cadf564f6a9e3ed8d18cabbbb7
    67 Nd02d3ac5a69f49c8b2fc070ff7e2159e
    68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020099324
    69 https://doi.org/10.1038/nmeth.3407
    70 schema:sdDatePublished 2019-04-11T00:23
    71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    72 schema:sdPublisher Nc4a104daa9f4492a8b888d45a8df26d1
    73 schema:url http://www.nature.com/articles/nmeth.3407
    74 sgo:license sg:explorer/license/
    75 sgo:sdDataset articles
    76 rdf:type schema:ScholarlyArticle
    77 N00d98f78e3b54f45b61893b80b6b0fbe schema:affiliation https://www.grid.ac/institutes/grid.418377.e
    78 schema:familyName Bertrand
    79 schema:givenName Denis
    80 rdf:type schema:Person
    81 N02199140ee1b473bb47bd717a0c4e533 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    82 schema:name Polymorphism, Single Nucleotide
    83 rdf:type schema:DefinedTerm
    84 N02d5f51f1e47435eba41823cb3bd6e1f rdf:first sg:person.01263725354.52
    85 rdf:rest N692898d8fb8d44d4b25a2fd96c3300a6
    86 N035fa3e8f9b14aaebcbd24133e4f98a3 rdf:first sg:person.01130665441.72
    87 rdf:rest Nd5ce9ade6b3f4cafac1c20c52389412d
    88 N082f007079a548bc825ca36d9b61d476 rdf:first N410d86e79a90449aaebca12f8e8c6899
    89 rdf:rest Nfcaff78dd82a4bb5802cade02ee60010
    90 N08e483e070d24a8cb0ac88958c73d463 rdf:first sg:person.01355471663.56
    91 rdf:rest Necdaa294a05a466dae0aa8663d469863
    92 N0a006821c17541778a6c6332896ef8f9 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    93 schema:familyName Hu
    94 schema:givenName Ying
    95 rdf:type schema:Person
    96 N0acb08632415444fa05fa4de0ea43f21 rdf:first sg:person.01176032221.25
    97 rdf:rest Nd0c39aafc5f447d7abf8ec2b4b09c8d9
    98 N0d91eba2347a43bd95ac07004ecc2484 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    99 schema:familyName Xi
    100 schema:givenName Liu
    101 rdf:type schema:Person
    102 N127df10996a742328c807e179844035d rdf:first sg:person.011660703047.33
    103 rdf:rest N54672990181c4a3491ec38491ea4993d
    104 N1615983d10714ecd80e0e86e59cbfc3c rdf:first Nf159de02170a42a68ceaa0b9207cd82d
    105 rdf:rest N9d3b037adddc4db39fdc08bec760461c
    106 N188d4d7e72a64a3fa92f3c08e857221d schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    107 schema:familyName Shi
    108 schema:givenName Wei
    109 rdf:type schema:Person
    110 N199ea67387034d32b110cf047f1b122e schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    111 schema:familyName Bergelson
    112 schema:givenName Louis
    113 rdf:type schema:Person
    114 N19ea91e2e9584b219cec60e1ced10626 rdf:first Ncb3a538934be47979daa3590cfe54468
    115 rdf:rest N97b966fca7644cb1b19725fb73efa302
    116 N1b49dc76e0cc4ae38abfb4a18791c740 rdf:first N36530797892a42acabc131801858d127
    117 rdf:rest Na151c2f8f9c5456281dfac7b9c594cc1
    118 N1b579efc5bf94b5084151e0bffb1a14b schema:affiliation https://www.grid.ac/institutes/grid.418377.e
    119 schema:familyName Li
    120 schema:givenName Chenhao
    121 rdf:type schema:Person
    122 N1db339d319994518bfb83662babea188 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    123 schema:familyName Kibbe
    124 schema:givenName Warren
    125 rdf:type schema:Person
    126 N1e90e32424354909aad760180bd1117e rdf:first Nb1ec6ce415ae457aac2c2c5325872c95
    127 rdf:rest N1b49dc76e0cc4ae38abfb4a18791c740
    128 N1f92630a35e44155a1d43942dd1d4bc5 rdf:first sg:person.01005050133.50
    129 rdf:rest Nd37a0ca4ca9b41d9b27e2bcd0717f2a3
    130 N231e61e2feea4d88858aa3e2ccd1c725 rdf:first Na721f48a949d4ad390853b594387d696
    131 rdf:rest Nde1832a8b4564f7c82d39ca9f69f46cb
    132 N249d3559f4fb463d82f11a89f334b3ed rdf:first N188d4d7e72a64a3fa92f3c08e857221d
    133 rdf:rest Ncefc94499fa945179a716c7c15577655
    134 N2725c6702af8449aa8c99a94f4c83fee rdf:first sg:person.01071473722.03
    135 rdf:rest N035fa3e8f9b14aaebcbd24133e4f98a3
    136 N2aa7b962a07f4cf3a402d907fc2a6561 rdf:first N00d98f78e3b54f45b61893b80b6b0fbe
    137 rdf:rest N34785072a9934f53a9963adef1bea605
    138 N3194873d9a7a4825aa540466bad098d9 schema:name readcube_id
    139 schema:value 5fc42816bcb118cb45b9080bc19c5ec7dde4dfeadd0116be6454026e28a3c011
    140 rdf:type schema:PropertyValue
    141 N33bf7b29848c4c95973e426d3ed9496b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Algorithms
    143 rdf:type schema:DefinedTerm
    144 N34785072a9934f53a9963adef1bea605 rdf:first sg:person.0653720306.72
    145 rdf:rest N1e90e32424354909aad760180bd1117e
    146 N36530797892a42acabc131801858d127 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    147 schema:familyName Hsu
    148 schema:givenName Chih-Hao
    149 rdf:type schema:Person
    150 N37b931d0386f4afa88c3f3f2aa129382 rdf:first sg:person.0667343407.95
    151 rdf:rest N4f24d35f5d164216b005a09499953a28
    152 N4038b6e65954490b9848735baed9b3f2 schema:affiliation https://www.grid.ac/institutes/grid.411667.3
    153 schema:familyName Wang
    154 schema:givenName Difei
    155 rdf:type schema:Person
    156 N410d86e79a90449aaebca12f8e8c6899 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    157 schema:familyName Rosenberg
    158 schema:givenName Mara
    159 rdf:type schema:Person
    160 N42b2898ee55e462f98ee012b86e1c388 rdf:first sg:person.0777551331.45
    161 rdf:rest Nd6a8df582078455b9ae44672bf78a2f5
    162 N4de36da556b6406f90311ad2ab6a3daa rdf:first sg:person.0765035064.26
    163 rdf:rest Nc177c2aa774e43ec9f226d4d5eec867c
    164 N4f24d35f5d164216b005a09499953a28 rdf:first sg:person.01276344410.81
    165 rdf:rest N8edd66c2bb6e42a5a4174e3272b398af
    166 N54672990181c4a3491ec38491ea4993d rdf:first sg:person.0620314676.44
    167 rdf:rest Nfb8b6a9f43804bf7bc3d9f9844c580c6
    168 N5725e7b69dc443709417d938f22a0245 schema:name pubmed_id
    169 schema:value 25984700
    170 rdf:type schema:PropertyValue
    171 N62271c4dfa754b7cbfea69c76e36433a rdf:first sg:person.01127752143.12
    172 rdf:rest rdf:nil
    173 N66318fa8070b4c5f8b44fa53d538c4cb rdf:first sg:person.0716312730.25
    174 rdf:rest N231e61e2feea4d88858aa3e2ccd1c725
    175 N682f28d270d645beb711ea1a25061b2a schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    176 schema:familyName Yan
    177 schema:givenName Chunhua
    178 rdf:type schema:Person
    179 N692898d8fb8d44d4b25a2fd96c3300a6 rdf:first sg:person.01042231561.33
    180 rdf:rest N2725c6702af8449aa8c99a94f4c83fee
    181 N6e8e84afffc149f48a489bb1dec1e31b rdf:first N682f28d270d645beb711ea1a25061b2a
    182 rdf:rest Nb63f8662503641769b11c2b2066b371e
    183 N742fa72d072a471ba03be3b34f863a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Crowdsourcing
    185 rdf:type schema:DefinedTerm
    186 N769d617495e54b32b9b1e0683eca0a63 schema:volumeNumber 12
    187 rdf:type schema:PublicationVolume
    188 N83296e77b2834144b702edcf4147de91 rdf:first Nea95108275114395add58a917d25ad20
    189 rdf:rest N1f92630a35e44155a1d43942dd1d4bc5
    190 N838fb87d4d314ef7b20186b5065209f3 schema:affiliation https://www.grid.ac/institutes/grid.418116.b
    191 schema:familyName Ferrari
    192 schema:givenName Anthony
    193 rdf:type schema:Person
    194 N8df0f51b6508450586b881037526dba5 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    195 schema:familyName Lau
    196 schema:givenName Cheryl C K
    197 rdf:type schema:Person
    198 N8edd66c2bb6e42a5a4174e3272b398af rdf:first sg:person.01051552560.34
    199 rdf:rest Nfddc6ae10b1d4f588a7e134da8ea9325
    200 N8f858709db04478aa260d747f868f175 rdf:first sg:person.013467131537.65
    201 rdf:rest N62271c4dfa754b7cbfea69c76e36433a
    202 N8f91a9ca2e7f442a8f63dfa52f38b4a5 rdf:first N4038b6e65954490b9848735baed9b3f2
    203 rdf:rest N83296e77b2834144b702edcf4147de91
    204 N97b966fca7644cb1b19725fb73efa302 rdf:first sg:person.01273152703.54
    205 rdf:rest Naf2ad5fea94a47f69b6a07ece53837e8
    206 N9a05219c7a3c492a9aefee0df4a5a233 schema:name nlm_unique_id
    207 schema:value 101215604
    208 rdf:type schema:PropertyValue
    209 N9cc63a82195c41d1bb5a0ca21f014636 rdf:first sg:person.013732223267.18
    210 rdf:rest Nb8bc4f3c3d944549a8055cd1bd21afb7
    211 N9d3b037adddc4db39fdc08bec760461c rdf:first sg:person.011121241077.29
    212 rdf:rest Nee75983c8b5145e8a6091ba13f055610
    213 Na151c2f8f9c5456281dfac7b9c594cc1 rdf:first N0a006821c17541778a6c6332896ef8f9
    214 rdf:rest N6e8e84afffc149f48a489bb1dec1e31b
    215 Na721f48a949d4ad390853b594387d696 schema:affiliation https://www.grid.ac/institutes/grid.418377.e
    216 schema:familyName Ting
    217 schema:givenName Grace Hui
    218 rdf:type schema:Person
    219 Naf2ad5fea94a47f69b6a07ece53837e8 rdf:first Nbed0bd3d8a0944fa82c8b6df1fa8c2b4
    220 rdf:rest N8f91a9ca2e7f442a8f63dfa52f38b4a5
    221 Nb1a3f5cadf564f6a9e3ed8d18cabbbb7 schema:name dimensions_id
    222 schema:value pub.1020099324
    223 rdf:type schema:PropertyValue
    224 Nb1ec6ce415ae457aac2c2c5325872c95 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    225 schema:familyName Chen
    226 schema:givenName Qing-Rong
    227 rdf:type schema:Person
    228 Nb63f8662503641769b11c2b2066b371e rdf:first N1db339d319994518bfb83662babea188
    229 rdf:rest N9cc63a82195c41d1bb5a0ca21f014636
    230 Nb7660e8d9395418fb52bbdfa689fda72 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    231 schema:familyName Wheeler
    232 schema:givenName David
    233 rdf:type schema:Person
    234 Nb8011c564cad415891151a0ba734bc72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Genome
    236 rdf:type schema:DefinedTerm
    237 Nb8bc4f3c3d944549a8055cd1bd21afb7 rdf:first Ncc5dbfab3bc54d6985f7c756cdf51985
    238 rdf:rest N082f007079a548bc825ca36d9b61d476
    239 Nbed0bd3d8a0944fa82c8b6df1fa8c2b4 schema:affiliation Nc0b9ed0e2c8c432db7c9d82a0a974563
    240 schema:familyName Hansen
    241 schema:givenName Nancy F
    242 rdf:type schema:Person
    243 Nbfe272675abc49188de74dc0446d8152 rdf:first sg:person.01277712747.19
    244 rdf:rest Nd22a6ec662c543c4907cf17a9902fb39
    245 Nc0b9ed0e2c8c432db7c9d82a0a974563 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    246 Team Shimmer, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
    247 rdf:type schema:Organization
    248 Nc0e02242d04841e1bc6574ec61257d71 rdf:first sg:person.0673542511.51
    249 rdf:rest N4de36da556b6406f90311ad2ab6a3daa
    250 Nc177c2aa774e43ec9f226d4d5eec867c rdf:first N838fb87d4d314ef7b20186b5065209f3
    251 rdf:rest N19ea91e2e9584b219cec60e1ced10626
    252 Nc4a104daa9f4492a8b888d45a8df26d1 schema:name Springer Nature - SN SciGraph project
    253 rdf:type schema:Organization
    254 Ncb3a538934be47979daa3590cfe54468 schema:affiliation https://www.grid.ac/institutes/grid.418116.b
    255 schema:familyName Tonton
    256 schema:givenName Laurie
    257 rdf:type schema:Person
    258 Ncc09f92f2b2b489d812780eab1a1f44c rdf:first sg:person.0576402465.48
    259 rdf:rest N1615983d10714ecd80e0e86e59cbfc3c
    260 Ncc5dbfab3bc54d6985f7c756cdf51985 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    261 schema:familyName Cibulskis
    262 schema:givenName Kristian
    263 rdf:type schema:Person
    264 Ncefc94499fa945179a716c7c15577655 rdf:first sg:person.0635001201.16
    265 rdf:rest N42b2898ee55e462f98ee012b86e1c388
    266 Nd02d3ac5a69f49c8b2fc070ff7e2159e schema:name doi
    267 schema:value 10.1038/nmeth.3407
    268 rdf:type schema:PropertyValue
    269 Nd0c39aafc5f447d7abf8ec2b4b09c8d9 rdf:first sg:person.015427326220.97
    270 rdf:rest Ne6438745f311479aaf24464dfb4a48ed
    271 Nd22a6ec662c543c4907cf17a9902fb39 rdf:first sg:person.01322400234.33
    272 rdf:rest N8f858709db04478aa260d747f868f175
    273 Nd37a0ca4ca9b41d9b27e2bcd0717f2a3 rdf:first Nfe721e4508a0448881df62d8f60b737e
    274 rdf:rest N249d3559f4fb463d82f11a89f334b3ed
    275 Nd5ce9ade6b3f4cafac1c20c52389412d rdf:first sg:person.01256775602.15
    276 rdf:rest N0acb08632415444fa05fa4de0ea43f21
    277 Nd6a8df582078455b9ae44672bf78a2f5 rdf:first N8df0f51b6508450586b881037526dba5
    278 rdf:rest N127df10996a742328c807e179844035d
    279 Nde1832a8b4564f7c82d39ca9f69f46cb rdf:first N1b579efc5bf94b5084151e0bffb1a14b
    280 rdf:rest N2aa7b962a07f4cf3a402d907fc2a6561
    281 Ne2650e979f28458d8d344b66c86c5e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    282 schema:name Neoplasms
    283 rdf:type schema:DefinedTerm
    284 Ne6438745f311479aaf24464dfb4a48ed rdf:first N0d91eba2347a43bd95ac07004ecc2484
    285 rdf:rest Ncc09f92f2b2b489d812780eab1a1f44c
    286 Nea95108275114395add58a917d25ad20 schema:affiliation https://www.grid.ac/institutes/grid.411667.3
    287 schema:familyName Song
    288 schema:givenName Lei
    289 rdf:type schema:Person
    290 Necac959ea5474526811f10f1ff1bd517 schema:issueNumber 7
    291 rdf:type schema:PublicationIssue
    292 Necdaa294a05a466dae0aa8663d469863 rdf:first sg:person.0735727565.23
    293 rdf:rest Nbfe272675abc49188de74dc0446d8152
    294 Nee75983c8b5145e8a6091ba13f055610 rdf:first Nb7660e8d9395418fb52bbdfa689fda72
    295 rdf:rest N66318fa8070b4c5f8b44fa53d538c4cb
    296 Nf159de02170a42a68ceaa0b9207cd82d schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    297 schema:familyName Fan
    298 schema:givenName Yu
    299 rdf:type schema:Person
    300 Nf500774a5ae94691be80b075e165c4de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    301 schema:name Humans
    302 rdf:type schema:DefinedTerm
    303 Nf519f5d5838442bab7cf92f57b9d1b93 rdf:first sg:person.01274672135.88
    304 rdf:rest Nc0e02242d04841e1bc6574ec61257d71
    305 Nf9a7386fe2c641aab3aeba1b4a261d53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    306 schema:name Benchmarking
    307 rdf:type schema:DefinedTerm
    308 Nfb8b6a9f43804bf7bc3d9f9844c580c6 rdf:first sg:person.0772773367.25
    309 rdf:rest N08e483e070d24a8cb0ac88958c73d463
    310 Nfcaff78dd82a4bb5802cade02ee60010 rdf:first N199ea67387034d32b110cf047f1b122e
    311 rdf:rest Nf519f5d5838442bab7cf92f57b9d1b93
    312 Nfddc6ae10b1d4f588a7e134da8ea9325 rdf:first sg:person.01070176346.73
    313 rdf:rest N02d5f51f1e47435eba41823cb3bd6e1f
    314 Nfe721e4508a0448881df62d8f60b737e schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    315 schema:familyName Liao
    316 schema:givenName Yang
    317 rdf:type schema:Person
    318 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    319 schema:name Medical and Health Sciences
    320 rdf:type schema:DefinedTerm
    321 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    322 schema:name Oncology and Carcinogenesis
    323 rdf:type schema:DefinedTerm
    324 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    325 rdf:type schema:MonetaryGrant
    326 sg:grant.2482454 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    327 rdf:type schema:MonetaryGrant
    328 sg:grant.2689292 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    329 rdf:type schema:MonetaryGrant
    330 sg:grant.2696336 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    331 rdf:type schema:MonetaryGrant
    332 sg:grant.2725731 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    333 rdf:type schema:MonetaryGrant
    334 sg:grant.3805122 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    335 rdf:type schema:MonetaryGrant
    336 sg:grant.3860235 http://pending.schema.org/fundedItem sg:pub.10.1038/nmeth.3407
    337 rdf:type schema:MonetaryGrant
    338 sg:journal.1033763 schema:issn 1548-7091
    339 1548-7105
    340 schema:name Nature Methods
    341 rdf:type schema:Periodical
    342 sg:person.01005050133.50 schema:affiliation https://www.grid.ac/institutes/grid.418152.b
    343 schema:familyName Lai
    344 schema:givenName Zhongwu
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005050133.50
    346 rdf:type schema:Person
    347 sg:person.01042231561.33 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    348 schema:familyName Yamaguchi
    349 schema:givenName Takafumi N
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042231561.33
    351 rdf:type schema:Person
    352 sg:person.01051552560.34 schema:affiliation https://www.grid.ac/institutes/grid.430406.5
    353 schema:familyName Hu
    354 schema:givenName Yin
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051552560.34
    356 rdf:type schema:Person
    357 sg:person.01070176346.73 schema:affiliation https://www.grid.ac/institutes/grid.205975.c
    358 schema:familyName Ellrott
    359 schema:givenName Kyle
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070176346.73
    361 rdf:type schema:Person
    362 sg:person.01071473722.03 schema:affiliation https://www.grid.ac/institutes/grid.430406.5
    363 schema:familyName Bare
    364 schema:givenName J Christopher
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071473722.03
    366 rdf:type schema:Person
    367 sg:person.011121241077.29 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    368 schema:familyName Wang
    369 schema:givenName Wenyi
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011121241077.29
    371 rdf:type schema:Person
    372 sg:person.01127752143.12 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
    373 schema:familyName Boutros
    374 schema:givenName Paul C
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127752143.12
    376 rdf:type schema:Person
    377 sg:person.01130665441.72 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    378 schema:familyName P'ng
    379 schema:givenName Christine
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130665441.72
    381 rdf:type schema:Person
    382 sg:person.011660703047.33 schema:affiliation https://www.grid.ac/institutes/grid.430406.5
    383 schema:familyName Guinney
    384 schema:givenName Justin
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011660703047.33
    386 rdf:type schema:Person
    387 sg:person.01176032221.25 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    388 schema:familyName Sabelnykova
    389 schema:givenName Veronica Y
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176032221.25
    391 rdf:type schema:Person
    392 sg:person.01256775602.15 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    393 schema:familyName Waggott
    394 schema:givenName Daryl
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256775602.15
    396 rdf:type schema:Person
    397 sg:person.01263725354.52 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    398 schema:familyName Caloian
    399 schema:givenName Cristian
    400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263725354.52
    401 rdf:type schema:Person
    402 sg:person.01273152703.54 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    403 schema:familyName Bhutani
    404 schema:givenName Kunal
    405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273152703.54
    406 rdf:type schema:Person
    407 sg:person.01274672135.88 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    408 schema:familyName Kiezun
    409 schema:givenName Adam
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274672135.88
    411 rdf:type schema:Person
    412 sg:person.01276344410.81 schema:affiliation https://www.grid.ac/institutes/grid.419890.d
    413 schema:familyName Houlahan
    414 schema:givenName Kathleen E
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276344410.81
    416 rdf:type schema:Person
    417 sg:person.01277712747.19 schema:affiliation https://www.grid.ac/institutes/grid.481554.9
    418 schema:familyName Stolovitzky
    419 schema:givenName Gustavo
    420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277712747.19
    421 rdf:type schema:Person
    422 sg:person.01322400234.33 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
    423 schema:familyName Margolin
    424 schema:givenName Adam A
    425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322400234.33
    426 rdf:type schema:Person
    427 sg:person.013467131537.65 schema:affiliation https://www.grid.ac/institutes/grid.205975.c
    428 schema:familyName Stuart
    429 schema:givenName Joshua M
    430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013467131537.65
    431 rdf:type schema:Person
    432 sg:person.01355471663.56 schema:affiliation https://www.grid.ac/institutes/grid.205975.c
    433 schema:familyName Haussler
    434 schema:givenName David
    435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355471663.56
    436 rdf:type schema:Person
    437 sg:person.013732223267.18 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    438 schema:familyName Meerzaman
    439 schema:givenName Daoud
    440 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732223267.18
    441 rdf:type schema:Person
    442 sg:person.015427326220.97 schema:familyName participants
    443 schema:givenName ICGC-TCGA DREAM Somatic Mutation Calling Challenge
    444 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015427326220.97
    445 rdf:type schema:Person
    446 sg:person.0576402465.48 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    447 schema:familyName Dewal
    448 schema:givenName Ninad
    449 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576402465.48
    450 rdf:type schema:Person
    451 sg:person.0620314676.44 schema:affiliation https://www.grid.ac/institutes/grid.430406.5
    452 schema:familyName Kellen
    453 schema:givenName Michael R
    454 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620314676.44
    455 rdf:type schema:Person
    456 sg:person.0635001201.16 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    457 schema:familyName Carbonell-Caballero
    458 schema:givenName José
    459 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635001201.16
    460 rdf:type schema:Person
    461 sg:person.0653720306.72 schema:affiliation https://www.grid.ac/institutes/grid.418377.e
    462 schema:familyName Nagarajan
    463 schema:givenName Niranjan
    464 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653720306.72
    465 rdf:type schema:Person
    466 sg:person.0667343407.95 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
    467 schema:familyName Ewing
    468 schema:givenName Adam D
    469 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667343407.95
    470 rdf:type schema:Person
    471 sg:person.0673542511.51 schema:affiliation https://www.grid.ac/institutes/grid.205975.c
    472 schema:familyName Radenbaugh
    473 schema:givenName Amie
    474 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673542511.51
    475 rdf:type schema:Person
    476 sg:person.0716312730.25 schema:affiliation https://www.grid.ac/institutes/grid.418377.e
    477 schema:familyName Wilm
    478 schema:givenName Andreas
    479 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716312730.25
    480 rdf:type schema:Person
    481 sg:person.0735727565.23 schema:affiliation https://www.grid.ac/institutes/grid.430406.5
    482 schema:familyName Friend
    483 schema:givenName Stephen H
    484 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735727565.23
    485 rdf:type schema:Person
    486 sg:person.0765035064.26 schema:affiliation https://www.grid.ac/institutes/grid.418116.b
    487 schema:familyName Sertier
    488 schema:givenName Anne-Sophie
    489 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765035064.26
    490 rdf:type schema:Person
    491 sg:person.0772773367.25 schema:affiliation https://www.grid.ac/institutes/grid.430406.5
    492 schema:familyName Norman
    493 schema:givenName Thea C
    494 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772773367.25
    495 rdf:type schema:Person
    496 sg:person.0777551331.45 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    497 schema:familyName Dopazo
    498 schema:givenName Joaquín
    499 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777551331.45
    500 rdf:type schema:Person
    501 sg:pub.10.1038/nature12113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004984574
    502 https://doi.org/10.1038/nature12113
    503 rdf:type schema:CreativeWork
    504 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
    505 https://doi.org/10.1038/nature12477
    506 rdf:type schema:CreativeWork
    507 sg:pub.10.1038/nature12912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043554069
    508 https://doi.org/10.1038/nature12912
    509 rdf:type schema:CreativeWork
    510 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
    511 https://doi.org/10.1038/nbt.1754
    512 rdf:type schema:CreativeWork
    513 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
    514 https://doi.org/10.1038/nbt.2514
    515 rdf:type schema:CreativeWork
    516 sg:pub.10.1038/ng.2761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014954618
    517 https://doi.org/10.1038/ng.2761
    518 rdf:type schema:CreativeWork
    519 sg:pub.10.1038/ng.2762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048811261
    520 https://doi.org/10.1038/ng.2762
    521 rdf:type schema:CreativeWork
    522 sg:pub.10.1038/ng.2932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019739342
    523 https://doi.org/10.1038/ng.2932
    524 rdf:type schema:CreativeWork
    525 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
    526 https://doi.org/10.1038/nmeth.1923
    527 rdf:type schema:CreativeWork
    528 sg:pub.10.1038/nmeth.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023029250
    529 https://doi.org/10.1038/nmeth.2016
    530 rdf:type schema:CreativeWork
    531 sg:pub.10.1038/nmeth.3094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052951347
    532 https://doi.org/10.1038/nmeth.3094
    533 rdf:type schema:CreativeWork
    534 sg:pub.10.1038/nrd3199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029459317
    535 https://doi.org/10.1038/nrd3199
    536 rdf:type schema:CreativeWork
    537 sg:pub.10.1186/1471-2105-12-451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028554628
    538 https://doi.org/10.1186/1471-2105-12-451
    539 rdf:type schema:CreativeWork
    540 sg:pub.10.1186/1471-2105-14-189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025914035
    541 https://doi.org/10.1186/1471-2105-14-189
    542 rdf:type schema:CreativeWork
    543 sg:pub.10.1186/1471-2105-14-s3-s1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051469122
    544 https://doi.org/10.1186/1471-2105-14-s3-s1
    545 rdf:type schema:CreativeWork
    546 sg:pub.10.1186/1471-2105-14-s5-s1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013312853
    547 https://doi.org/10.1186/1471-2105-14-s5-s1
    548 rdf:type schema:CreativeWork
    549 sg:pub.10.1186/1471-2105-14-s9-s1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038027122
    550 https://doi.org/10.1186/1471-2105-14-s9-s1
    551 rdf:type schema:CreativeWork
    552 sg:pub.10.1186/1471-2105-8-25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019863657
    553 https://doi.org/10.1186/1471-2105-8-25
    554 rdf:type schema:CreativeWork
    555 sg:pub.10.1186/1471-2105-9-307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042870683
    556 https://doi.org/10.1186/1471-2105-9-307
    557 rdf:type schema:CreativeWork
    558 sg:pub.10.1186/gm432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033686767
    559 https://doi.org/10.1186/gm432
    560 rdf:type schema:CreativeWork
    561 sg:pub.10.1186/s13059-014-0462-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020949465
    562 https://doi.org/10.1186/s13059-014-0462-7
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1002/ijc.27817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002827685
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1002/prot.22534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031722717
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1016/j.cell.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045709558
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1021/ci034160g schema:sameAs https://app.dimensions.ai/details/publication/pub.1013785151
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1073/pnas.1530509100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044620917
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1093/bioinformatics/btp373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008270984
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1093/bioinformatics/btq033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036892131
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1093/bioinformatics/btq057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025260149
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1093/bioinformatics/btr330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018404011
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1093/bioinformatics/btr665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000466381
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1093/bioinformatics/bts187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039045908
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1093/bioinformatics/bts271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036846543
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1093/biostatistics/kxj011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020482831
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1093/nar/gkr344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049624779
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1126/scitranslmed.3006112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015623460
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1200/jco.2011.39.2316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006401474
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1371/journal.pone.0111516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046668666
    603 rdf:type schema:CreativeWork
    604 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
    605 schema:name Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.
    606 ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    607 Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.
    608 rdf:type schema:Organization
    609 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
    610 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    611 Team WEHI-Subread, Department of Computing and Information Systems, The University of Melbourne, Melbourne, Victoria, Australia.
    612 Team WEHI-Subread, Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
    613 rdf:type schema:Organization
    614 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
    615 schema:name Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
    616 Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
    617 ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    618 Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
    619 rdf:type schema:Organization
    620 https://www.grid.ac/institutes/grid.205975.c schema:alternateName University of California, Santa Cruz
    621 schema:name Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, USA.
    622 ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    623 rdf:type schema:Organization
    624 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    625 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    626 Team Wang Wheeler HGSC, Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    627 rdf:type schema:Organization
    628 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
    629 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    630 Team Virmid, Bioinformatics and Systems Biology, University of California, San Diego, La Jolla, California, USA.
    631 rdf:type schema:Organization
    632 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
    633 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    634 Team Wang Wheeler HGSC, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
    635 Team Wang Wheeler HGSC, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
    636 rdf:type schema:Organization
    637 https://www.grid.ac/institutes/grid.411667.3 schema:alternateName Georgetown University Medical Center
    638 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    639 Team 2014, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
    640 Team 2014, Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.
    641 rdf:type schema:Organization
    642 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
    643 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    644 Team Germmatic, Functional Genomics Node (INB) at Príncipe Felipe Research Center (CIPF), Valencia, Spain.
    645 rdf:type schema:Organization
    646 https://www.grid.ac/institutes/grid.418116.b schema:alternateName Centre Léon Bérard
    647 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    648 Team SLC Platform, Synergie Lyon Cancer Foundation, Centre Léon Bérard, Lyon, France.
    649 rdf:type schema:Organization
    650 https://www.grid.ac/institutes/grid.418152.b schema:alternateName AstraZeneca (United States)
    651 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    652 Team AstraZeneca, AstraZeneca, Waltham, Massachusetts, USA.
    653 rdf:type schema:Organization
    654 https://www.grid.ac/institutes/grid.418377.e schema:alternateName Genome Institute of Singapore
    655 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    656 Team LoFreq Somatic GIS, Genome Institute of Singapore, Computational and Systems Biology, Singapore.
    657 rdf:type schema:Organization
    658 https://www.grid.ac/institutes/grid.419890.d schema:alternateName Ontario Institute for Cancer Research
    659 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    660 Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
    661 rdf:type schema:Organization
    662 https://www.grid.ac/institutes/grid.430406.5 schema:alternateName Sage Bionetworks
    663 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    664 Sage Bionetworks, Seattle, Washington, USA.
    665 rdf:type schema:Organization
    666 https://www.grid.ac/institutes/grid.481554.9 schema:alternateName IBM Research – Thomas J. Watson Research Center
    667 schema:name IBM Computational Biology Center, T.J. Watson Research Center, Yorktown Heights, New York, USA.
    668 rdf:type schema:Organization
    669 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
    670 schema:name Computational Biology Program, Oregon Health & Science University, Portland, Oregon, USA.
    671 Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
    672 ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    673 Sage Bionetworks, Seattle, Washington, USA.
    674 rdf:type schema:Organization
    675 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
    676 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    677 Team Broad, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
    678 rdf:type schema:Organization
    679 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
    680 schema:name ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants
    681 Team DMUT, Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.
    682 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...