Fast and sensitive protein alignment using DIAMOND View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Benjamin Buchfink, Chao Xie, Daniel H Huson

ABSTRACT

The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity. More... »

PAGES

59-60

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth.3176

DOI

http://dx.doi.org/10.1038/nmeth.3176

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023901695

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25402007


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