A bioinformatic assay for pluripotency in human cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Franz-Josef Müller, Bernhard M Schuldt, Roy Williams, Dylan Mason, Gulsah Altun, Eirini P Papapetrou, Sandra Danner, Johanna E Goldmann, Arne Herbst, Nils O Schmidt, Josef B Aldenhoff, Louise C Laurent, Jeanne F Loring

ABSTRACT

Pluripotent stem cells (PSCs) are defined by their potential to generate all cell types of an organism. The standard assay for pluripotency of mouse PSCs is cell transmission through the germline, but for human PSCs researchers depend on indirect methods such as differentiation into teratomas in immunodeficient mice. Here we report PluriTest, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles. More... »

PAGES

315

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth.1580

DOI

http://dx.doi.org/10.1038/nmeth.1580

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033394588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21378979


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