A chemical platform for improved induction of human iPSCs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10-18

AUTHORS

Tongxiang Lin, Rajesh Ambasudhan, Xu Yuan, Wenlin Li, Simon Hilcove, Ramzey Abujarour, Xiangyi Lin, Heung Sik Hahm, Ergeng Hao, Alberto Hayek, Sheng Ding

ABSTRACT

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells. More... »

PAGES

805-808

References to SciGraph publications

Journal

TITLE

Nature Methods

ISSUE

11

VOLUME

6

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmeth.1393

    DOI

    http://dx.doi.org/10.1038/nmeth.1393

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029588621

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19838168


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