Direct determination of haplotypes from single DNA molecules View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

Ming Xiao, Eunice Wan, Catherine Chu, Wen-Chi Hsueh, Yang Cao, Pui-Yan Kwok

ABSTRACT

Determining the long-range haplotypes in a diploid individual is a major technical challenge. Here we report a method of molecular haplotyping by directly imaging multiple polymorphic sites on individual human DNA molecules simultaneously. We demonstrate the utility of this technology by accurately determining the haplotypes consisting of up to 16 single-nucleotide polymorphisms in genomic regions up to 50 kilobases. More... »

PAGES

199-201

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmeth.1301

DOI

http://dx.doi.org/10.1038/nmeth.1301

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026196282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19198595


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