Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Erzsébet Bartolák-Suki, Jasmin Imsirovic, Harikrishnan Parameswaran, Tyler J. Wellman, Nuria Martinez, Philip G. Allen, Urs Frey, Béla Suki

ABSTRACT

Cells can be exposed to irregular mechanical fluctuations, such as those arising from changes in blood pressure. Here, we report that ATP production, assessed through changes in mitochondrial membrane potential, is downregulated in vascular smooth muscle cells in culture exposed to monotonous stretch cycles when compared with cells exposed to a variable cyclic stretch that incorporates physiological levels of cycle-by-cycle variability in stretch amplitude. Variable stretch enhances ATP production by increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase and its tyrosine phosphorylation, mitofusins and PGC-1α. Such a fluctuation-driven mechanotransduction mechanism is mediated by motor proteins and by the enhancement of microtubule-, actin- and mitochondrial-network complexity. We also show that, in aorta rings isolated from rats, monotonous stretch downregulates-whereas variable stretch maintains-physiological vessel-wall contractility through mitochondrial ATP production. Our results have implications for ATP-dependent and mechanosensitive intracellular processes. More... »

PAGES

1049-1057

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nmat4358

DOI

http://dx.doi.org/10.1038/nmat4358

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052785028

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26213900


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP Synthetase Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalytic Domain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electron Transport Complex IV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP Phosphohydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mechanotransduction, Cellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress, Mechanical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bartol\u00e1k-Suki", 
        "givenName": "Erzs\u00e9bet", 
        "id": "sg:person.010506062527.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010506062527.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imsirovic", 
        "givenName": "Jasmin", 
        "id": "sg:person.0720042314.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720042314.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parameswaran", 
        "givenName": "Harikrishnan", 
        "id": "sg:person.01217531635.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217531635.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wellman", 
        "givenName": "Tyler J.", 
        "id": "sg:person.0610514577.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610514577.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez", 
        "givenName": "Nuria", 
        "id": "sg:person.0611711731.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611711731.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allen", 
        "givenName": "Philip G.", 
        "id": "sg:person.0610354135.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610354135.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Children\u2019s Hospital Basel", 
          "id": "https://www.grid.ac/institutes/grid.412347.7", 
          "name": [
            "University Children\u2019s Hospital Basel, CH-4031 Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frey", 
        "givenName": "Urs", 
        "id": "sg:person.01352205174.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352205174.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University", 
          "id": "https://www.grid.ac/institutes/grid.189504.1", 
          "name": [
            "Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suki", 
        "givenName": "B\u00e9la", 
        "id": "sg:person.0730323706.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730323706.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35014065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001190577", 
          "https://doi.org/10.1038/35014065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35014065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001190577", 
          "https://doi.org/10.1038/35014065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbabio.2006.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003140412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004484652", 
          "https://doi.org/10.1038/nature10316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004484652", 
          "https://doi.org/10.1038/nature10316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004484652", 
          "https://doi.org/10.1038/nature10316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/biom.24650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005606844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.05-5424rev", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006964675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1107402108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007884954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2013.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008786324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e02-06-0330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008909155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80611-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016332582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.75.8.3863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017586223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018642484", 
          "https://doi.org/10.1038/nrm2786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018642484", 
          "https://doi.org/10.1038/nrm2786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.35254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021210357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.2616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024897642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2011.03.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025737296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.90454.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025776510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2009-0073oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025887831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(88)83158-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027102793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00962.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027797798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0270(96)00080-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028366178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e318054dfe3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029155041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e318054dfe3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029155041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m411335200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031936904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034611518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m104029200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035351146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00042.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038162808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038206998", 
          "https://doi.org/10.1038/nrm759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038206998", 
          "https://doi.org/10.1038/nrm759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.100.4.1041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038248220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20071072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039190659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20071072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039190659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0703-599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041368152", 
          "https://doi.org/10.1038/ncb0703-599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0703-599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041368152", 
          "https://doi.org/10.1038/ncb0703-599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m212754200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042889402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m800137-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043147955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000071708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043336233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagen.2009.04.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043778523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00175.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047171625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.017376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047965669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jemt.1070270303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049309533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10237-007-0101-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050673534", 
          "https://doi.org/10.1007/s10237-007-0101-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10237-007-0101-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050673534", 
          "https://doi.org/10.1007/s10237-007-0101-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052077917", 
          "https://doi.org/10.1038/35065745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052077917", 
          "https://doi.org/10.1038/35065745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00069.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052870303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00069.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052870303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.088708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052923037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.088708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052923037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00228a031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055166168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00036.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063195017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.2000.88.4.1365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074617440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077042910", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077400078", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "Cells can be exposed to irregular mechanical fluctuations, such as those arising from changes in blood pressure. Here, we report that ATP production, assessed through changes in mitochondrial membrane potential, is downregulated in vascular smooth muscle cells in culture exposed to monotonous stretch cycles when compared with cells exposed to a variable cyclic stretch that incorporates physiological levels of cycle-by-cycle variability in stretch amplitude. Variable stretch enhances ATP production by increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase and its tyrosine phosphorylation, mitofusins and PGC-1\u03b1. Such a fluctuation-driven mechanotransduction mechanism is mediated by motor proteins and by the enhancement of microtubule-, actin- and mitochondrial-network complexity. We also show that, in aorta rings isolated from rats, monotonous stretch downregulates-whereas variable stretch maintains-physiological vessel-wall contractility through mitochondrial ATP production. Our results have implications for ATP-dependent and mechanosensitive intracellular\u00a0processes. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nmat4358", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2542775", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3624144", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031408", 
        "issn": [
          "1476-1122", 
          "1476-4660"
        ], 
        "name": "Nature Materials", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function", 
    "pagination": "1049-1057", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fb6e70e737860f40051c6980a3700cdcdd5273c1e7388a8bf61498935e748abe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26213900"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101155473"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nmat4358"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052785028"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nmat4358", 
      "https://app.dimensions.ai/details/publication/pub.1052785028"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nmat/journal/v14/n10/full/nmat4358.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nmat4358'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nmat4358'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nmat4358'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nmat4358'


 

This table displays all metadata directly associated to this object as RDF triples.

358 TRIPLES      21 PREDICATES      97 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nmat4358 schema:about N0837e1d5051f4ec7883fd854c7f78d8f
2 N0a34d79469a2496ea870222f3ab1d622
3 N11637166744d4b6d98f0024e2d4057c9
4 N19557935715a4fb4ae16b97bbbb432f4
5 N2a2506950201490fba831888115d7b13
6 N42fb6f8fb63c444c91425c7d67e4e8a2
7 N50c2df52c91c4e4c9f8d358e6859d510
8 N559ab0646c694db7aa227e8d8002161a
9 N58ac7cc08bce498da86f288e225cc62e
10 N60440687ba444d7ba3efc7b4a233ae01
11 N62666b7c4b264d269db3ce761fb53ba6
12 N76d1da84465146f483e8d7a0ff08903d
13 N7d0390b4a82b40198be4de0d3fc56350
14 N83bc627ddfb34bdc904eb6e00558d0d6
15 N9b8450f60ddf47d5a35945744c9e4170
16 N9cb7c98dc0774ccc8273a7e4571b7693
17 Na867112325d5471ca1d8863ad118cd2d
18 Nb78a5b632c9546228e0d32f29d18663a
19 Nd00d92fd460d4e8f914d8d45d685c0a2
20 Nec7da604cd164fc780f7fd77b346369a
21 Nee1c74aa418b49c69f9e9657555f12be
22 Nf4776188587948f6b50272ced55f135d
23 Nf6e2cd42d8ef42cea929c21b29ebca3b
24 Nf846bcc000594b49875e02fba4e4b60b
25 anzsrc-for:06
26 anzsrc-for:0601
27 schema:author N2d896e3daa9946e9b182f35888b13c43
28 schema:citation sg:pub.10.1007/s10237-007-0101-2
29 sg:pub.10.1038/35014065
30 sg:pub.10.1038/35065745
31 sg:pub.10.1038/nature10316
32 sg:pub.10.1038/ncb0703-599
33 sg:pub.10.1038/nrm2786
34 sg:pub.10.1038/nrm759
35 https://app.dimensions.ai/details/publication/pub.1077042910
36 https://app.dimensions.ai/details/publication/pub.1077400078
37 https://doi.org/10.1002/jbm.a.35254
38 https://doi.org/10.1002/jemt.1070270303
39 https://doi.org/10.1006/bbrc.2000.2616
40 https://doi.org/10.1016/j.bbabio.2006.04.013
41 https://doi.org/10.1016/j.bbagen.2009.04.019
42 https://doi.org/10.1016/j.bbamcr.2013.02.002
43 https://doi.org/10.1016/j.cmet.2011.03.024
44 https://doi.org/10.1016/s0006-3495(88)83158-8
45 https://doi.org/10.1016/s0092-8674(00)80611-x
46 https://doi.org/10.1016/s0165-0270(96)00080-5
47 https://doi.org/10.1021/bi00228a031
48 https://doi.org/10.1042/bj20071072
49 https://doi.org/10.1073/pnas.1107402108
50 https://doi.org/10.1073/pnas.75.8.3863
51 https://doi.org/10.1074/jbc.m104029200
52 https://doi.org/10.1074/jbc.m109.017376
53 https://doi.org/10.1074/jbc.m212754200
54 https://doi.org/10.1074/jbc.m411335200
55 https://doi.org/10.1074/mcp.m800137-mcp200
56 https://doi.org/10.1083/jcb.100.4.1041
57 https://doi.org/10.1091/mbc.e02-06-0330
58 https://doi.org/10.1096/fj.05-5424rev
59 https://doi.org/10.1097/shk.0b013e318054dfe3
60 https://doi.org/10.1152/ajplung.00036.2003
61 https://doi.org/10.1152/ajplung.00069.2005
62 https://doi.org/10.1152/ajplung.00175.2011
63 https://doi.org/10.1152/ajplung.90454.2008
64 https://doi.org/10.1152/jappl.2000.88.4.1365
65 https://doi.org/10.1152/japplphysiol.00962.2013
66 https://doi.org/10.1152/physiol.00042.2009
67 https://doi.org/10.1159/000071708
68 https://doi.org/10.1161/hypertensionaha.107.088708
69 https://doi.org/10.1165/rcmb.2009-0073oc
70 https://doi.org/10.1242/jcs.00479
71 https://doi.org/10.4161/biom.24650
72 schema:datePublished 2015-10
73 schema:datePublishedReg 2015-10-01
74 schema:description Cells can be exposed to irregular mechanical fluctuations, such as those arising from changes in blood pressure. Here, we report that ATP production, assessed through changes in mitochondrial membrane potential, is downregulated in vascular smooth muscle cells in culture exposed to monotonous stretch cycles when compared with cells exposed to a variable cyclic stretch that incorporates physiological levels of cycle-by-cycle variability in stretch amplitude. Variable stretch enhances ATP production by increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase and its tyrosine phosphorylation, mitofusins and PGC-1α. Such a fluctuation-driven mechanotransduction mechanism is mediated by motor proteins and by the enhancement of microtubule-, actin- and mitochondrial-network complexity. We also show that, in aorta rings isolated from rats, monotonous stretch downregulates-whereas variable stretch maintains-physiological vessel-wall contractility through mitochondrial ATP production. Our results have implications for ATP-dependent and mechanosensitive intracellular processes.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N6545699036e248f3930d3468dd4bdc1c
79 N6b3c5645742f4ac7ac51d32e1a9695d6
80 sg:journal.1031408
81 schema:name Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function
82 schema:pagination 1049-1057
83 schema:productId N0664f45bcb2b4e16804bc779480c37bc
84 N4a31c6251ff340a7a47d51518ff23e99
85 N6cc5bb3992404506b78d26e5384e46e5
86 N89d1eb4620b147d5abd1f367c264e6b0
87 Nbcfb7108371042259f738ab0863262e8
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052785028
89 https://doi.org/10.1038/nmat4358
90 schema:sdDatePublished 2019-04-10T22:19
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N27468de2a77a4940a41d4bcc83dff872
93 schema:url http://www.nature.com/nmat/journal/v14/n10/full/nmat4358.html
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0664f45bcb2b4e16804bc779480c37bc schema:name doi
98 schema:value 10.1038/nmat4358
99 rdf:type schema:PropertyValue
100 N077ab1ce04544a0aa5d64e8fda7cffa9 rdf:first sg:person.0610514577.48
101 rdf:rest Nfed80969051d48f9acf5a8da8c537d0d
102 N0837e1d5051f4ec7883fd854c7f78d8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Electron Transport Complex IV
104 rdf:type schema:DefinedTerm
105 N0a34d79469a2496ea870222f3ab1d622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Animals
107 rdf:type schema:DefinedTerm
108 N11637166744d4b6d98f0024e2d4057c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adolescent
110 rdf:type schema:DefinedTerm
111 N19557935715a4fb4ae16b97bbbb432f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Membrane Potentials
113 rdf:type schema:DefinedTerm
114 N27468de2a77a4940a41d4bcc83dff872 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N2a2506950201490fba831888115d7b13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Phosphorylation
118 rdf:type schema:DefinedTerm
119 N2d896e3daa9946e9b182f35888b13c43 rdf:first sg:person.010506062527.53
120 rdf:rest Nab4d9b93b7c442639cad01d8e5ccffd2
121 N33df9842c4454311b9fba68f3b307fdc rdf:first sg:person.0610354135.24
122 rdf:rest N4af3e5bb1bf54cd5bec62038d72c7037
123 N42fb6f8fb63c444c91425c7d67e4e8a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Stress, Mechanical
125 rdf:type schema:DefinedTerm
126 N4a31c6251ff340a7a47d51518ff23e99 schema:name dimensions_id
127 schema:value pub.1052785028
128 rdf:type schema:PropertyValue
129 N4af3e5bb1bf54cd5bec62038d72c7037 rdf:first sg:person.01352205174.11
130 rdf:rest N9f6e9612989d4184908fa40059a79d8e
131 N50c2df52c91c4e4c9f8d358e6859d510 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Middle Aged
133 rdf:type schema:DefinedTerm
134 N559ab0646c694db7aa227e8d8002161a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Tyrosine
136 rdf:type schema:DefinedTerm
137 N58ac7cc08bce498da86f288e225cc62e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mitochondrial Membrane Transport Proteins
139 rdf:type schema:DefinedTerm
140 N60440687ba444d7ba3efc7b4a233ae01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adult
142 rdf:type schema:DefinedTerm
143 N62666b7c4b264d269db3ce761fb53ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Young Adult
145 rdf:type schema:DefinedTerm
146 N6545699036e248f3930d3468dd4bdc1c schema:issueNumber 10
147 rdf:type schema:PublicationIssue
148 N6b3c5645742f4ac7ac51d32e1a9695d6 schema:volumeNumber 14
149 rdf:type schema:PublicationVolume
150 N6cc5bb3992404506b78d26e5384e46e5 schema:name pubmed_id
151 schema:value 26213900
152 rdf:type schema:PropertyValue
153 N76d1da84465146f483e8d7a0ff08903d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Muscle, Smooth, Vascular
155 rdf:type schema:DefinedTerm
156 N7d0390b4a82b40198be4de0d3fc56350 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Aorta
158 rdf:type schema:DefinedTerm
159 N83bc627ddfb34bdc904eb6e00558d0d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name ATP Synthetase Complexes
161 rdf:type schema:DefinedTerm
162 N89d1eb4620b147d5abd1f367c264e6b0 schema:name readcube_id
163 schema:value fb6e70e737860f40051c6980a3700cdcdd5273c1e7388a8bf61498935e748abe
164 rdf:type schema:PropertyValue
165 N9b8450f60ddf47d5a35945744c9e4170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Adenosine Triphosphate
167 rdf:type schema:DefinedTerm
168 N9cb7c98dc0774ccc8273a7e4571b7693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Mechanotransduction, Cellular
170 rdf:type schema:DefinedTerm
171 N9f6e9612989d4184908fa40059a79d8e rdf:first sg:person.0730323706.34
172 rdf:rest rdf:nil
173 Na867112325d5471ca1d8863ad118cd2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name GTP Phosphohydrolases
175 rdf:type schema:DefinedTerm
176 Nab4d9b93b7c442639cad01d8e5ccffd2 rdf:first sg:person.0720042314.49
177 rdf:rest Nbcc01f88381942baae312fcfee2ca03c
178 Nb78a5b632c9546228e0d32f29d18663a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Transcription Factors
180 rdf:type schema:DefinedTerm
181 Nbcc01f88381942baae312fcfee2ca03c rdf:first sg:person.01217531635.53
182 rdf:rest N077ab1ce04544a0aa5d64e8fda7cffa9
183 Nbcfb7108371042259f738ab0863262e8 schema:name nlm_unique_id
184 schema:value 101155473
185 rdf:type schema:PropertyValue
186 Nd00d92fd460d4e8f914d8d45d685c0a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Mitochondria
188 rdf:type schema:DefinedTerm
189 Nec7da604cd164fc780f7fd77b346369a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Catalytic Domain
191 rdf:type schema:DefinedTerm
192 Nee1c74aa418b49c69f9e9657555f12be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Rats
194 rdf:type schema:DefinedTerm
195 Nf4776188587948f6b50272ced55f135d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Cattle
197 rdf:type schema:DefinedTerm
198 Nf6e2cd42d8ef42cea929c21b29ebca3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
200 rdf:type schema:DefinedTerm
201 Nf846bcc000594b49875e02fba4e4b60b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Humans
203 rdf:type schema:DefinedTerm
204 Nfed80969051d48f9acf5a8da8c537d0d rdf:first sg:person.0611711731.09
205 rdf:rest N33df9842c4454311b9fba68f3b307fdc
206 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
207 schema:name Biological Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
210 schema:name Biochemistry and Cell Biology
211 rdf:type schema:DefinedTerm
212 sg:grant.2542775 http://pending.schema.org/fundedItem sg:pub.10.1038/nmat4358
213 rdf:type schema:MonetaryGrant
214 sg:grant.3624144 http://pending.schema.org/fundedItem sg:pub.10.1038/nmat4358
215 rdf:type schema:MonetaryGrant
216 sg:journal.1031408 schema:issn 1476-1122
217 1476-4660
218 schema:name Nature Materials
219 rdf:type schema:Periodical
220 sg:person.010506062527.53 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
221 schema:familyName Bartolák-Suki
222 schema:givenName Erzsébet
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010506062527.53
224 rdf:type schema:Person
225 sg:person.01217531635.53 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
226 schema:familyName Parameswaran
227 schema:givenName Harikrishnan
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217531635.53
229 rdf:type schema:Person
230 sg:person.01352205174.11 schema:affiliation https://www.grid.ac/institutes/grid.412347.7
231 schema:familyName Frey
232 schema:givenName Urs
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352205174.11
234 rdf:type schema:Person
235 sg:person.0610354135.24 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
236 schema:familyName Allen
237 schema:givenName Philip G.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610354135.24
239 rdf:type schema:Person
240 sg:person.0610514577.48 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
241 schema:familyName Wellman
242 schema:givenName Tyler J.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610514577.48
244 rdf:type schema:Person
245 sg:person.0611711731.09 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
246 schema:familyName Martinez
247 schema:givenName Nuria
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611711731.09
249 rdf:type schema:Person
250 sg:person.0720042314.49 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
251 schema:familyName Imsirovic
252 schema:givenName Jasmin
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720042314.49
254 rdf:type schema:Person
255 sg:person.0730323706.34 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
256 schema:familyName Suki
257 schema:givenName Béla
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730323706.34
259 rdf:type schema:Person
260 sg:pub.10.1007/s10237-007-0101-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050673534
261 https://doi.org/10.1007/s10237-007-0101-2
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/35014065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001190577
264 https://doi.org/10.1038/35014065
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/35065745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052077917
267 https://doi.org/10.1038/35065745
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nature10316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004484652
270 https://doi.org/10.1038/nature10316
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/ncb0703-599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041368152
273 https://doi.org/10.1038/ncb0703-599
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nrm2786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018642484
276 https://doi.org/10.1038/nrm2786
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nrm759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038206998
279 https://doi.org/10.1038/nrm759
280 rdf:type schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1077042910 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1077400078 schema:CreativeWork
283 https://doi.org/10.1002/jbm.a.35254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021210357
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/jemt.1070270303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049309533
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1006/bbrc.2000.2616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024897642
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.bbabio.2006.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003140412
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.bbagen.2009.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043778523
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.bbamcr.2013.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008786324
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.cmet.2011.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025737296
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0006-3495(88)83158-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027102793
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0092-8674(00)80611-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016332582
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0165-0270(96)00080-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028366178
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1021/bi00228a031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055166168
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1042/bj20071072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039190659
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.1107402108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007884954
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.75.8.3863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017586223
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1074/jbc.m104029200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035351146
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.m109.017376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047965669
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1074/jbc.m212754200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042889402
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.m411335200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031936904
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/mcp.m800137-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043147955
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1083/jcb.100.4.1041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038248220
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1091/mbc.e02-06-0330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008909155
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1096/fj.05-5424rev schema:sameAs https://app.dimensions.ai/details/publication/pub.1006964675
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/shk.0b013e318054dfe3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029155041
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1152/ajplung.00036.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063195017
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1152/ajplung.00069.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052870303
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1152/ajplung.00175.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047171625
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1152/ajplung.90454.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025776510
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1152/jappl.2000.88.4.1365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074617440
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1152/japplphysiol.00962.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027797798
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1152/physiol.00042.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038162808
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1159/000071708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043336233
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1161/hypertensionaha.107.088708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052923037
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1165/rcmb.2009-0073oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1025887831
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1242/jcs.00479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034611518
350 rdf:type schema:CreativeWork
351 https://doi.org/10.4161/biom.24650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005606844
352 rdf:type schema:CreativeWork
353 https://www.grid.ac/institutes/grid.189504.1 schema:alternateName Boston University
354 schema:name Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
355 rdf:type schema:Organization
356 https://www.grid.ac/institutes/grid.412347.7 schema:alternateName University Children’s Hospital Basel
357 schema:name University Children’s Hospital Basel, CH-4031 Basel, Switzerland
358 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...