Delivery materials for siRNA therapeutics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Daniel Anderson

ABSTRACT

RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the most effective and clinically advanced classes of siRNA delivery systems, including lipid nanoparticles and siRNA conjugates, are designed to surmount these challenges. The systems that we discuss are diverse in their approaches to the delivery problem, and provide valuable insight to guide the design of future siRNA delivery materials. More... »

PAGES

967-977

References to SciGraph publications

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  • Journal

    TITLE

    Nature Materials

    ISSUE

    11

    VOLUME

    12

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nmat3765

    DOI

    http://dx.doi.org/10.1038/nmat3765

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001818681

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24150415


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