Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-03

AUTHORS

Rajnish A Gupta, Dingzhi Wang, Sharada Katkuri, Haibin Wang, Sudhansu K Dey, Raymond N DuBois

ABSTRACT

We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth. More... »

PAGES

245-247

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm993

DOI

http://dx.doi.org/10.1038/nm993

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023220637

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14758356


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