Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-01-25

AUTHORS

Christopher G Willett, Yves Boucher, Emmanuelle di Tomaso, Dan G Duda, Lance L Munn, Ricky T Tong, Daniel C Chung, Dushyant V Sahani, Sanjeeva P Kalva, Sergey V Kozin, Mari Mino, Kenneth S Cohen, David T Scadden, Alan C Hartford, Alan J Fischman, Jeffrey W Clark, David P Ryan, Andrew X Zhu, Lawrence S Blaszkowsky, Helen X Chen, Paul C Shellito, Gregory Y Lauwers, Rakesh K Jain

ABSTRACT

The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, circulating endothelial and progenitor cells, and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients. These data indicate that VEGF blockade has a direct and rapid antivascular effect in human tumors. More... »

PAGES

145-147

Journal

TITLE

Nature Medicine

ISSUE

2

VOLUME

10

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm988

    DOI

    http://dx.doi.org/10.1038/nm988

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003700365

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14745444


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