Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-09-21

AUTHORS

Catherine Uyttenhove, Luc Pilotte, Ivan Théate, Vincent Stroobant, Didier Colau, Nicolas Parmentier, Thierry Boon, Benoît J Van den Eynde

ABSTRACT

T lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme that is expressed in placenta and catalyzes tryptophan degradation. Here we show that most human tumors constitutively express IDO. We also observed that expression of IDO by immunogenic mouse tumor cells prevents their rejection by preimmunized mice. This effect is accompanied by a lack of accumulation of specific T cells at the tumor site and can be partly reverted by systemic treatment of mice with an inhibitor of IDO, in the absence of noticeable toxicity. These results suggest that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor. More... »

PAGES

1269-1274

Journal

TITLE

Nature Medicine

ISSUE

10

VOLUME

9

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm934

    DOI

    http://dx.doi.org/10.1038/nm934

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015972513

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14502282


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    67 results
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    72 therapeutic vaccination
    73 toxicity
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