Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-08

AUTHORS

Gustav Mattiasson, Mehrdad Shamloo, Gunilla Gido, Kavitha Mathi, Gregor Tomasevic, Saili Yi, Craig H. Warden, Roger F. Castilho, Thorsten Melcher, Mirella Gonzalez-Zulueta, Karoly Nikolich, Tadeusz Wieloch

ABSTRACT

Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing human UCP-2, brain damage was diminished after experimental stroke and traumatic brain injury, and neurological recovery was enhanced. In cultured cortical neurons, UCP-2 reduced cell death and inhibited caspase-3 activation induced by oxygen and glucose deprivation. Mild mitochondrial uncoupling by 2,4-dinitrophenol (DNP) reduced neuronal death, and UCP-2 activity was enhanced by palmitic acid in isolated mitochondria. Also in isolated mitochondria, UCP-2 shifted the release of reactive oxygen species from the mitochondrial matrix to the extramitochondrial space. We propose that UCP-2 is an inducible protein that is neuroprotective by activating cellular redox signaling or by inducing mild mitochondrial uncoupling that prevents the release of apoptogenic proteins. More... »

PAGES

1062-1068

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm903

DOI

http://dx.doi.org/10.1038/nm903

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011171935

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12858170


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Injuries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroprotective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stroke", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uncoupling Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uncoupling Protein 2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Wallenberg Neuroscience Center, BMC A13, 221 84 Lund, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mattiasson", 
        "givenName": "Gustav", 
        "id": "sg:person.01264363051.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264363051.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shamloo", 
        "givenName": "Mehrdad", 
        "id": "sg:person.01263370267.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263370267.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Wallenberg Neuroscience Center, BMC A13, 221 84 Lund, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gido", 
        "givenName": "Gunilla", 
        "id": "sg:person.01132554260.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132554260.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathi", 
        "givenName": "Kavitha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Wallenberg Neuroscience Center, BMC A13, 221 84 Lund, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomasevic", 
        "givenName": "Gregor", 
        "id": "sg:person.0627346425.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627346425.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yi", 
        "givenName": "Saili", 
        "id": "sg:person.01043421456.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043421456.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, School of Medicine, University of California, Davis, California 95616, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Warden", 
        "givenName": "Craig H.", 
        "id": "sg:person.01211245320.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211245320.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Department of Clinical Pathology, School of Medical Sciences, State University of Campinas, Campinas, S\u00e3o Paulo 13083-970, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castilho", 
        "givenName": "Roger F.", 
        "id": "sg:person.01333230615.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333230615.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melcher", 
        "givenName": "Thorsten", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez-Zulueta", 
        "givenName": "Mirella", 
        "id": "sg:person.01277754760.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277754760.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nikolich", 
        "givenName": "Karoly", 
        "id": "sg:person.01207660715.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207660715.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Wallenberg Neuroscience Center, BMC A13, 221 84 Lund, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wieloch", 
        "givenName": "Tadeusz", 
        "id": "sg:person.0776320473.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776320473.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m107955200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000399693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.15.8721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002352101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.12.6025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003425878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(99)01401-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007069159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.1.436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008084517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exmp.1999.2288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008521757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199902000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008706669", 
          "https://doi.org/10.1097/00004647-199902000-00009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199902000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008706669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199902000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008706669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.29.9.1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014276628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199607000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016144969", 
          "https://doi.org/10.1097/00004647-199607000-00010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199607000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016144969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199607000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016144969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.4577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016236213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0891-5849(94)00166-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016273268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1990.tb04189.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017855813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019830643", 
          "https://doi.org/10.1038/74994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019830643", 
          "https://doi.org/10.1038/74994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004419900154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021558214", 
          "https://doi.org/10.1007/s004419900154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004419900154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021558214", 
          "https://doi.org/10.1007/s004419900154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0397-269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023017082", 
          "https://doi.org/10.1038/ng0397-269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/niox.1999.0229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026480595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0802257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028430378", 
          "https://doi.org/10.1038/sj.ijo.0802257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0802257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028430378", 
          "https://doi.org/10.1038/sj.ijo.0802257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15216540152845984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029259247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/415096a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029796081", 
          "https://doi.org/10.1038/415096a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/415096a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029796081", 
          "https://doi.org/10.1038/415096a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030371001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030371001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1995.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030536171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1995.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030536171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031480889", 
          "https://doi.org/10.1038/17135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031480889", 
          "https://doi.org/10.1038/17135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m202535200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(02)01166-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035047317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036415800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1988.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036415800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15216540152846064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036625923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1998.0870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039989630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(70)90086-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040506061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(70)90086-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040506061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1385-299x(99)00060-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041059293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1027328510931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043534248", 
          "https://doi.org/10.1023/a:1027328510931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1467-789x.2001.00043.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045005350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(98)01073-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045165612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.012410699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046625848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.6.1302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046842797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-2728(98)00122-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047264973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199907000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047534010", 
          "https://doi.org/10.1097/00004647-199907000-00008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199907000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047534010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199907000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047534010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/82565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049529582", 
          "https://doi.org/10.1038/82565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/82565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049529582", 
          "https://doi.org/10.1038/82565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35046114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049686544", 
          "https://doi.org/10.1038/35046114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1998.tb09913.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051038652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1998.tb09913.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051038652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(02)03734-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053425966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/08977150151070919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059201364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.1995.12.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059299510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.1997.14.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059299671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2000.17.843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059300032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.19-05-01657.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074251928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.2000.89.4.1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074704375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.11.10.9271366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083135211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.18-24-10277.1998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083361392"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-08", 
    "datePublishedReg": "2003-08-01", 
    "description": "Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing human UCP-2, brain damage was diminished after experimental stroke and traumatic brain injury, and neurological recovery was enhanced. In cultured cortical neurons, UCP-2 reduced cell death and inhibited caspase-3 activation induced by oxygen and glucose deprivation. Mild mitochondrial uncoupling by 2,4-dinitrophenol (DNP) reduced neuronal death, and UCP-2 activity was enhanced by palmitic acid in isolated mitochondria. Also in isolated mitochondria, UCP-2 shifted the release of reactive oxygen species from the mitochondrial matrix to the extramitochondrial space. We propose that UCP-2 is an inducible protein that is neuroprotective by activating cellular redox signaling or by inducing mild mitochondrial uncoupling that prevents the release of apoptogenic proteins.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm903", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4550084", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2496208", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma", 
    "pagination": "1062-1068", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "353a2617082c1800dba62371ba267d5262fcd0ac6b48715b6b15a9378c5ef53b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12858170"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm903"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011171935"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm903", 
      "https://app.dimensions.ai/details/publication/pub.1011171935"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87091_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nm903"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm903'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm903'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm903'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm903'


 

This table displays all metadata directly associated to this object as RDF triples.

427 TRIPLES      21 PREDICATES      104 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm903 schema:about N0dc6a52a2535486e9153cfc7225fc31d
2 N24284ab79b584fa897ae17e41a6ea6d5
3 N2ae7c58d416842c88e92fc14e9ef0f31
4 N2be85e60f36045cfabe6b53a88ccc470
5 N418b742dfa0b49e6afee7de429ef2af4
6 N45798e496da84673867717a06d9b238f
7 N5e4b320a7b2e492ab81c551ca5d41518
8 N7c40db3a957a47308664aa5fb9578bea
9 N81de96b115eb46d7b3e1624929024f16
10 N8b2cd4df03a144dfbceac9388dc4285c
11 N98a93b5c5e7f438f8123d5516670cb59
12 N9b3cbac291094212a25b29d73ab3f2cb
13 N9e4c315ff04445c6b282465d986e612f
14 Na9cf2c8e92a84a1e86535a81bd4f3847
15 Nb7e51bbc94f346f88ec6e7bf9f17f8d6
16 Nbc237ae01f2f4432b56ba1948ad94e24
17 Nbce0120beee54917bacce6ff603b3be4
18 Nc53d8ebe7ccc4054afd0aee6e242ad80
19 Ncd772efad6f641209d941cc865e7dd7f
20 Nd025e95fc11a467ca88f5e34a3f3797e
21 Nd1a84784e53449c1aae531aad79abd07
22 Ndd05c2866be5480ea72203c303a46e19
23 Ned417462dba644248576cde53c1ea9d6
24 Nfddf54ea836940b88a8f482ce7bb9811
25 anzsrc-for:11
26 anzsrc-for:1109
27 schema:author N0a3cd23259cf4f809be12bb1133809b6
28 schema:citation sg:pub.10.1007/s004419900154
29 sg:pub.10.1023/a:1027328510931
30 sg:pub.10.1038/17135
31 sg:pub.10.1038/35046114
32 sg:pub.10.1038/415096a
33 sg:pub.10.1038/74994
34 sg:pub.10.1038/82565
35 sg:pub.10.1038/ng0397-269
36 sg:pub.10.1038/sj.ijo.0802257
37 sg:pub.10.1097/00004647-199607000-00010
38 sg:pub.10.1097/00004647-199902000-00009
39 sg:pub.10.1097/00004647-199907000-00008
40 https://doi.org/10.1006/abbi.1998.0870
41 https://doi.org/10.1006/bbrc.2001.4577
42 https://doi.org/10.1006/exmp.1999.2288
43 https://doi.org/10.1006/niox.1999.0229
44 https://doi.org/10.1016/0005-2760(70)90086-x
45 https://doi.org/10.1016/0891-5849(94)00166-h
46 https://doi.org/10.1016/s0005-2728(98)00122-4
47 https://doi.org/10.1016/s0006-2952(02)01166-8
48 https://doi.org/10.1016/s0014-5793(02)03734-1
49 https://doi.org/10.1016/s0014-5793(98)01073-4
50 https://doi.org/10.1016/s0166-2236(99)01401-0
51 https://doi.org/10.1016/s1385-299x(99)00060-4
52 https://doi.org/10.1038/jcbfm.1988.87
53 https://doi.org/10.1038/jcbfm.1995.7
54 https://doi.org/10.1042/bj20021077
55 https://doi.org/10.1046/j.1467-789x.2001.00043.x
56 https://doi.org/10.1073/pnas.012410699
57 https://doi.org/10.1073/pnas.93.12.6025
58 https://doi.org/10.1073/pnas.96.15.8721
59 https://doi.org/10.1073/pnas.97.1.436
60 https://doi.org/10.1074/jbc.m107955200
61 https://doi.org/10.1074/jbc.m202535200
62 https://doi.org/10.1080/15216540152845984
63 https://doi.org/10.1080/15216540152846064
64 https://doi.org/10.1089/08977150151070919
65 https://doi.org/10.1089/neu.1995.12.169
66 https://doi.org/10.1089/neu.1997.14.23
67 https://doi.org/10.1089/neu.2000.17.843
68 https://doi.org/10.1096/fasebj.11.10.9271366
69 https://doi.org/10.1097/00004647-199607000-00010
70 https://doi.org/10.1097/00004647-199902000-00009
71 https://doi.org/10.1097/00004647-199907000-00008
72 https://doi.org/10.1111/j.1471-4159.1990.tb04189.x
73 https://doi.org/10.1111/j.1749-6632.1998.tb09913.x
74 https://doi.org/10.1152/jappl.2000.89.4.1491
75 https://doi.org/10.1161/01.str.29.9.1937
76 https://doi.org/10.1523/jneurosci.18-24-10277.1998
77 https://doi.org/10.1523/jneurosci.19-05-01657.1999
78 https://doi.org/10.2337/diabetes.50.6.1302
79 schema:datePublished 2003-08
80 schema:datePublishedReg 2003-08-01
81 schema:description Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing human UCP-2, brain damage was diminished after experimental stroke and traumatic brain injury, and neurological recovery was enhanced. In cultured cortical neurons, UCP-2 reduced cell death and inhibited caspase-3 activation induced by oxygen and glucose deprivation. Mild mitochondrial uncoupling by 2,4-dinitrophenol (DNP) reduced neuronal death, and UCP-2 activity was enhanced by palmitic acid in isolated mitochondria. Also in isolated mitochondria, UCP-2 shifted the release of reactive oxygen species from the mitochondrial matrix to the extramitochondrial space. We propose that UCP-2 is an inducible protein that is neuroprotective by activating cellular redox signaling or by inducing mild mitochondrial uncoupling that prevents the release of apoptogenic proteins.
82 schema:genre research_article
83 schema:inLanguage en
84 schema:isAccessibleForFree false
85 schema:isPartOf N0e150a60f92d4715badc0c8b83f92b1d
86 Na0bc954fa7b44ab9813cdf2e01fdc3d7
87 sg:journal.1113716
88 schema:name Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
89 schema:pagination 1062-1068
90 schema:productId N1ea9546218a843eb8b12433863b1b70e
91 N7c476ffb9a8f44c58e209e8e06bf616e
92 N96b5907bd59a4cecaf8831e6ed9e80e0
93 Nb2cbc6ef11ad435699baa8b414580410
94 Nb394ebe397c54e7fac48ecd74984907d
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011171935
96 https://doi.org/10.1038/nm903
97 schema:sdDatePublished 2019-04-11T12:23
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher Nc05c572f676d4c368c0cc8cab5b0c629
100 schema:url http://www.nature.com/articles/nm903
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N00fb765cb1084ac7b0e0c2f9c02391ee rdf:first sg:person.01263370267.25
105 rdf:rest N1378f4ee9e8b4958b11c318610005886
106 N0841d77722fa43ac93f03ebafced75dc schema:name AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA.
107 rdf:type schema:Organization
108 N0a030b9949894fa89869109f5f4a39bd schema:name AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA.
109 rdf:type schema:Organization
110 N0a3cd23259cf4f809be12bb1133809b6 rdf:first sg:person.01264363051.89
111 rdf:rest N00fb765cb1084ac7b0e0c2f9c02391ee
112 N0d74e922a7a34435a407f40083793e84 schema:name AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA.
113 rdf:type schema:Organization
114 N0dc6a52a2535486e9153cfc7225fc31d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Uncoupling Agents
116 rdf:type schema:DefinedTerm
117 N0e150a60f92d4715badc0c8b83f92b1d schema:issueNumber 8
118 rdf:type schema:PublicationIssue
119 N11ba63259c7747c8b3ad8467035d8b47 rdf:first N7edbc6a710e145eebb7bf53647b0886a
120 rdf:rest Nc7d03fd9fd224d48a695ebbeeb21908e
121 N1378f4ee9e8b4958b11c318610005886 rdf:first sg:person.01132554260.38
122 rdf:rest N11ba63259c7747c8b3ad8467035d8b47
123 N1bfdbe4cdff14e1a84ba894347f597fa schema:name AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA.
124 rdf:type schema:Organization
125 N1ea9546218a843eb8b12433863b1b70e schema:name nlm_unique_id
126 schema:value 9502015
127 rdf:type schema:PropertyValue
128 N24284ab79b584fa897ae17e41a6ea6d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Neuroprotective Agents
130 rdf:type schema:DefinedTerm
131 N29ff48decad540a89576074b494ed1e3 rdf:first sg:person.01207660715.06
132 rdf:rest N3791ea53d67344aaae86a096e72c9569
133 N2ae7c58d416842c88e92fc14e9ef0f31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Proteins
135 rdf:type schema:DefinedTerm
136 N2be85e60f36045cfabe6b53a88ccc470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Rats
138 rdf:type schema:DefinedTerm
139 N3791ea53d67344aaae86a096e72c9569 rdf:first sg:person.0776320473.38
140 rdf:rest rdf:nil
141 N418b742dfa0b49e6afee7de429ef2af4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Caspases
143 rdf:type schema:DefinedTerm
144 N45798e496da84673867717a06d9b238f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Mitochondrial Proteins
146 rdf:type schema:DefinedTerm
147 N5e4b320a7b2e492ab81c551ca5d41518 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Ion Channels
149 rdf:type schema:DefinedTerm
150 N68e3bc1c9cb64624b698dbc7ece454bf rdf:first sg:person.01043421456.89
151 rdf:rest N81b11f29d52a4f3d91b9d650f3d1bf31
152 N7c40db3a957a47308664aa5fb9578bea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Stroke
154 rdf:type schema:DefinedTerm
155 N7c476ffb9a8f44c58e209e8e06bf616e schema:name dimensions_id
156 schema:value pub.1011171935
157 rdf:type schema:PropertyValue
158 N7edbc6a710e145eebb7bf53647b0886a schema:affiliation N0d74e922a7a34435a407f40083793e84
159 schema:familyName Mathi
160 schema:givenName Kavitha
161 rdf:type schema:Person
162 N81b11f29d52a4f3d91b9d650f3d1bf31 rdf:first sg:person.01211245320.44
163 rdf:rest Naa472f757f394a83a993a1145fc06d98
164 N81de96b115eb46d7b3e1624929024f16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Membrane Transport Proteins
166 rdf:type schema:DefinedTerm
167 N8b2cd4df03a144dfbceac9388dc4285c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 N8e6444866fc64a3b9a9060386534e9fc rdf:first sg:person.01277754760.57
171 rdf:rest N29ff48decad540a89576074b494ed1e3
172 N96b5907bd59a4cecaf8831e6ed9e80e0 schema:name readcube_id
173 schema:value 353a2617082c1800dba62371ba267d5262fcd0ac6b48715b6b15a9378c5ef53b
174 rdf:type schema:PropertyValue
175 N98a93b5c5e7f438f8123d5516670cb59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Brain
177 rdf:type schema:DefinedTerm
178 N9b3cbac291094212a25b29d73ab3f2cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Neurons
180 rdf:type schema:DefinedTerm
181 N9e4c315ff04445c6b282465d986e612f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Uncoupling Protein 2
183 rdf:type schema:DefinedTerm
184 Na0bc954fa7b44ab9813cdf2e01fdc3d7 schema:volumeNumber 9
185 rdf:type schema:PublicationVolume
186 Na9cf2c8e92a84a1e86535a81bd4f3847 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Cells, Cultured
188 rdf:type schema:DefinedTerm
189 Naa472f757f394a83a993a1145fc06d98 rdf:first sg:person.01333230615.79
190 rdf:rest Ncedbfa0463604575aa3d4f4948c39c88
191 Nb2cbc6ef11ad435699baa8b414580410 schema:name doi
192 schema:value 10.1038/nm903
193 rdf:type schema:PropertyValue
194 Nb394ebe397c54e7fac48ecd74984907d schema:name pubmed_id
195 schema:value 12858170
196 rdf:type schema:PropertyValue
197 Nb7e51bbc94f346f88ec6e7bf9f17f8d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Animals
199 rdf:type schema:DefinedTerm
200 Nbc237ae01f2f4432b56ba1948ad94e24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Brain Injuries
202 rdf:type schema:DefinedTerm
203 Nbce0120beee54917bacce6ff603b3be4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Oligonucleotide Array Sequence Analysis
205 rdf:type schema:DefinedTerm
206 Nc05c572f676d4c368c0cc8cab5b0c629 schema:name Springer Nature - SN SciGraph project
207 rdf:type schema:Organization
208 Nc53d8ebe7ccc4054afd0aee6e242ad80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Caspase 3
210 rdf:type schema:DefinedTerm
211 Nc7d03fd9fd224d48a695ebbeeb21908e rdf:first sg:person.0627346425.72
212 rdf:rest N68e3bc1c9cb64624b698dbc7ece454bf
213 Ncd772efad6f641209d941cc865e7dd7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Cell Death
215 rdf:type schema:DefinedTerm
216 Ncedbfa0463604575aa3d4f4948c39c88 rdf:first Nd626c7e6419b4a1db6203ba5afbd80c2
217 rdf:rest N8e6444866fc64a3b9a9060386534e9fc
218 Nd025e95fc11a467ca88f5e34a3f3797e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Reactive Oxygen Species
220 rdf:type schema:DefinedTerm
221 Nd1a84784e53449c1aae531aad79abd07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Mitochondria
223 rdf:type schema:DefinedTerm
224 Nd4df026aef174bda9fc83e543441d142 schema:name AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA.
225 rdf:type schema:Organization
226 Nd626c7e6419b4a1db6203ba5afbd80c2 schema:affiliation N0841d77722fa43ac93f03ebafced75dc
227 schema:familyName Melcher
228 schema:givenName Thorsten
229 rdf:type schema:Person
230 Ndd05c2866be5480ea72203c303a46e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Mice
232 rdf:type schema:DefinedTerm
233 Ned417462dba644248576cde53c1ea9d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Ischemia
235 rdf:type schema:DefinedTerm
236 Nfa6f8bb664e64573be348d71a8498f4b schema:name AGY Therapeutics Inc., 290 Utah Ave, South San Francisco, California 94080, USA.
237 rdf:type schema:Organization
238 Nfddf54ea836940b88a8f482ce7bb9811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Mice, Transgenic
240 rdf:type schema:DefinedTerm
241 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
242 schema:name Medical and Health Sciences
243 rdf:type schema:DefinedTerm
244 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
245 schema:name Neurosciences
246 rdf:type schema:DefinedTerm
247 sg:grant.2496208 http://pending.schema.org/fundedItem sg:pub.10.1038/nm903
248 rdf:type schema:MonetaryGrant
249 sg:grant.4550084 http://pending.schema.org/fundedItem sg:pub.10.1038/nm903
250 rdf:type schema:MonetaryGrant
251 sg:journal.1113716 schema:issn 1078-8956
252 1546-170X
253 schema:name Nature Medicine
254 rdf:type schema:Periodical
255 sg:person.01043421456.89 schema:affiliation N0a030b9949894fa89869109f5f4a39bd
256 schema:familyName Yi
257 schema:givenName Saili
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043421456.89
259 rdf:type schema:Person
260 sg:person.01132554260.38 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
261 schema:familyName Gido
262 schema:givenName Gunilla
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132554260.38
264 rdf:type schema:Person
265 sg:person.01207660715.06 schema:affiliation Nfa6f8bb664e64573be348d71a8498f4b
266 schema:familyName Nikolich
267 schema:givenName Karoly
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207660715.06
269 rdf:type schema:Person
270 sg:person.01211245320.44 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
271 schema:familyName Warden
272 schema:givenName Craig H.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211245320.44
274 rdf:type schema:Person
275 sg:person.01263370267.25 schema:affiliation N1bfdbe4cdff14e1a84ba894347f597fa
276 schema:familyName Shamloo
277 schema:givenName Mehrdad
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263370267.25
279 rdf:type schema:Person
280 sg:person.01264363051.89 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
281 schema:familyName Mattiasson
282 schema:givenName Gustav
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264363051.89
284 rdf:type schema:Person
285 sg:person.01277754760.57 schema:affiliation Nd4df026aef174bda9fc83e543441d142
286 schema:familyName Gonzalez-Zulueta
287 schema:givenName Mirella
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277754760.57
289 rdf:type schema:Person
290 sg:person.01333230615.79 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
291 schema:familyName Castilho
292 schema:givenName Roger F.
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333230615.79
294 rdf:type schema:Person
295 sg:person.0627346425.72 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
296 schema:familyName Tomasevic
297 schema:givenName Gregor
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627346425.72
299 rdf:type schema:Person
300 sg:person.0776320473.38 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
301 schema:familyName Wieloch
302 schema:givenName Tadeusz
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776320473.38
304 rdf:type schema:Person
305 sg:pub.10.1007/s004419900154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021558214
306 https://doi.org/10.1007/s004419900154
307 rdf:type schema:CreativeWork
308 sg:pub.10.1023/a:1027328510931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043534248
309 https://doi.org/10.1023/a:1027328510931
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/17135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031480889
312 https://doi.org/10.1038/17135
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/35046114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049686544
315 https://doi.org/10.1038/35046114
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/415096a schema:sameAs https://app.dimensions.ai/details/publication/pub.1029796081
318 https://doi.org/10.1038/415096a
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/74994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019830643
321 https://doi.org/10.1038/74994
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/82565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049529582
324 https://doi.org/10.1038/82565
325 rdf:type schema:CreativeWork
326 sg:pub.10.1038/ng0397-269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023017082
327 https://doi.org/10.1038/ng0397-269
328 rdf:type schema:CreativeWork
329 sg:pub.10.1038/sj.ijo.0802257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028430378
330 https://doi.org/10.1038/sj.ijo.0802257
331 rdf:type schema:CreativeWork
332 sg:pub.10.1097/00004647-199607000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016144969
333 https://doi.org/10.1097/00004647-199607000-00010
334 rdf:type schema:CreativeWork
335 sg:pub.10.1097/00004647-199902000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008706669
336 https://doi.org/10.1097/00004647-199902000-00009
337 rdf:type schema:CreativeWork
338 sg:pub.10.1097/00004647-199907000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047534010
339 https://doi.org/10.1097/00004647-199907000-00008
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1006/abbi.1998.0870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039989630
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1006/bbrc.2001.4577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016236213
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1006/exmp.1999.2288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008521757
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1006/niox.1999.0229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026480595
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/0005-2760(70)90086-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040506061
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/0891-5849(94)00166-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1016273268
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/s0005-2728(98)00122-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047264973
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/s0006-2952(02)01166-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035047317
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/s0014-5793(02)03734-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053425966
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/s0014-5793(98)01073-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045165612
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/s0166-2236(99)01401-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007069159
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/s1385-299x(99)00060-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041059293
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1038/jcbfm.1988.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036415800
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1038/jcbfm.1995.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030536171
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1042/bj20021077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030371001
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1046/j.1467-789x.2001.00043.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045005350
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1073/pnas.012410699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046625848
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1073/pnas.93.12.6025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003425878
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1073/pnas.96.15.8721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002352101
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1073/pnas.97.1.436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008084517
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1074/jbc.m107955200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000399693
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1074/jbc.m202535200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031768057
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1080/15216540152845984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029259247
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1080/15216540152846064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036625923
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1089/08977150151070919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059201364
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1089/neu.1995.12.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059299510
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1089/neu.1997.14.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059299671
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1089/neu.2000.17.843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059300032
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1096/fasebj.11.10.9271366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083135211
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1097/00004647-199607000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016144969
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1097/00004647-199902000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008706669
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1097/00004647-199907000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047534010
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1111/j.1471-4159.1990.tb04189.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017855813
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1111/j.1749-6632.1998.tb09913.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051038652
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1152/jappl.2000.89.4.1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074704375
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1161/01.str.29.9.1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014276628
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1523/jneurosci.18-24-10277.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083361392
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1523/jneurosci.19-05-01657.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074251928
416 rdf:type schema:CreativeWork
417 https://doi.org/10.2337/diabetes.50.6.1302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046842797
418 rdf:type schema:CreativeWork
419 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
420 schema:name Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, School of Medicine, University of California, Davis, California 95616, USA.
421 rdf:type schema:Organization
422 https://www.grid.ac/institutes/grid.411087.b schema:alternateName State University of Campinas
423 schema:name Department of Clinical Pathology, School of Medical Sciences, State University of Campinas, Campinas, São Paulo 13083-970, Brazil.
424 rdf:type schema:Organization
425 https://www.grid.ac/institutes/grid.4514.4 schema:alternateName Lund University
426 schema:name Wallenberg Neuroscience Center, BMC A13, 221 84 Lund, Sweden.
427 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...