Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-06

AUTHORS

Silvana Obici, Zhaohui Feng, Arduino Arduini, Roberto Conti, Luciano Rossetti

ABSTRACT

The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty acid (LCFA) entry into mitochondria, where the LCFAs undergo beta-oxidation. To investigate the mechanism(s) by which central metabolism of lipids can modulate energy balance, we selectively reduced lipid oxidation in the hypothalamus. We decreased the activity of CPT1 by administering to rats a ribozyme-containing plasmid designed specifically to decrease the expression of this enzyme or by infusing pharmacological inhibitors of its activity into the third cerebral ventricle. Either genetic or biochemical inhibition of hypothalamic CPT1 activity was sufficient to substantially diminish food intake and endogenous glucose production. These results indicated that changes in the rate of lipid oxidation in selective hypothalamic neurons signaled nutrient availability to the hypothalamus, which in turn modulated the exogenous and endogenous inputs of nutrients into the circulation. More... »

PAGES

756

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm873

DOI

http://dx.doi.org/10.1038/nm873

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003936654

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12754501


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Agouti-Related Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carnitine O-Palmitoyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropeptide Y", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Catalytic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obici", 
        "givenName": "Silvana", 
        "id": "sg:person.01301621053.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301621053.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Zhaohui", 
        "id": "sg:person.01347734253.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347734253.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Metabolism & Endocrinology, Sigma Tau Pharmaceutical Industries, Via Pontina km 30,400, 00040 Pomezia, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arduini", 
        "givenName": "Arduino", 
        "id": "sg:person.01176452124.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176452124.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Metabolism & Endocrinology, Sigma Tau Pharmaceutical Industries, Via Pontina km 30,400, 00040 Pomezia, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conti", 
        "givenName": "Roberto", 
        "id": "sg:person.01231252217.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231252217.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossetti", 
        "givenName": "Luciano", 
        "id": "sg:person.0726655573.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726655573.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.012606199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000982773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002281544", 
          "https://doi.org/10.1038/31474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002281544", 
          "https://doi.org/10.1038/31474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.2.271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004441756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)90267-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004764018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35071088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014015421", 
          "https://doi.org/10.1038/35071088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35071088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014015421", 
          "https://doi.org/10.1038/35071088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1987.tb01021.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014705606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci108764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017952828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.16.7297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018266629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382250a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019931158", 
          "https://doi.org/10.1038/382250a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1994.62041530.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022478936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn0602-861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022530334", 
          "https://doi.org/10.1038/nn0602-861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn0602-861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022530334", 
          "https://doi.org/10.1038/nn0602-861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m211495200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027858626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1999.721759.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029779978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036745532", 
          "https://doi.org/10.1038/35007534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036745532", 
          "https://doi.org/10.1038/35007534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037649840", 
          "https://doi.org/10.1038/35007504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35007504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037649840", 
          "https://doi.org/10.1038/35007504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(73)90290-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038960030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(73)90290-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038960030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0202-179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038993554", 
          "https://doi.org/10.1038/nm0202-179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0202-179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038993554", 
          "https://doi.org/10.1038/nm0202-179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.47.31160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039744733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(85)90434-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041290814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/282503a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046852793", 
          "https://doi.org/10.1038/282503a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/282503a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046852793", 
          "https://doi.org/10.1038/282503a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047202492", 
          "https://doi.org/10.1038/sj.gt.3300635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047202492", 
          "https://doi.org/10.1038/sj.gt.3300635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.4.733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047208344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-136-35478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049021715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-136-35478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049021715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1997.t01-3-00001.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052765359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5368.1371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5475.2379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062570085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.289.5487.2122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci12954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.3.393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.46.3.393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070743513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077646274", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082811458", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-06", 
    "datePublishedReg": "2003-06-01", 
    "description": "The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty acid (LCFA) entry into mitochondria, where the LCFAs undergo beta-oxidation. To investigate the mechanism(s) by which central metabolism of lipids can modulate energy balance, we selectively reduced lipid oxidation in the hypothalamus. We decreased the activity of CPT1 by administering to rats a ribozyme-containing plasmid designed specifically to decrease the expression of this enzyme or by infusing pharmacological inhibitors of its activity into the third cerebral ventricle. Either genetic or biochemical inhibition of hypothalamic CPT1 activity was sufficient to substantially diminish food intake and endogenous glucose production. These results indicated that changes in the rate of lipid oxidation in selective hypothalamic neurons signaled nutrient availability to the hypothalamus, which in turn modulated the exogenous and endogenous inputs of nutrients into the circulation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm873", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2627710", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2494679", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634820", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2495274", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production", 
    "pagination": "756", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "12c18a66108ddcdc7c635be4b87daa202aa9a6c842b50f6daeba186f1ac0a758"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12754501"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm873"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003936654"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm873", 
      "https://app.dimensions.ai/details/publication/pub.1003936654"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87100_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nm873"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm873'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm873'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm873'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm873'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      80 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm873 schema:about N01d2880c3e60422289b93d9a88f32b9d
2 N05904c3444b2489e8617efbacca5a8c7
3 N118d914593e748409ae6c5ac03be16f8
4 N1638b34293f44062aba17cf667a7483c
5 N184b9eff04404b42841765d3ecb3d56d
6 N26258d20fde5464da823268c27fed967
7 N523cd27694f841d4843b547dfa04e1c5
8 N5ef849be6cc247c4a63710ede872ad4b
9 N8467d703982a4ca881cc6671ed80cfb8
10 N8b5caee5aee84f6ea2cd24b2f537a6b5
11 N8e69cc1f43a04b19bf3691aacc248fb5
12 N9985ab7badfd4533b7909ef8f5b8c42a
13 N9d49897a0de84425974be72dc467a9bf
14 Nd086f4f4787a42cca79f2dcc553ea263
15 Nd099d3f52cff4c8584abf97415141357
16 Nd0f86c94aa0e42a79faaed86882739f2
17 Ne2d7713aac604ea3843ebcff451fa5f8
18 Ne7ee05d5da324abda5654d0ee4b84290
19 Nf7158827ea54450b8e2330bab5020e50
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author Na0171d0c6fca40639862aa71895e8fcc
23 schema:citation sg:pub.10.1038/282503a0
24 sg:pub.10.1038/31474
25 sg:pub.10.1038/35007504
26 sg:pub.10.1038/35007534
27 sg:pub.10.1038/35071088
28 sg:pub.10.1038/382250a0
29 sg:pub.10.1038/nm0202-179
30 sg:pub.10.1038/nn0602-861
31 sg:pub.10.1038/sj.gt.3300635
32 https://app.dimensions.ai/details/publication/pub.1077646274
33 https://app.dimensions.ai/details/publication/pub.1082811458
34 https://doi.org/10.1016/0003-2697(85)90434-8
35 https://doi.org/10.1016/0006-8993(73)90290-4
36 https://doi.org/10.1016/s0140-6736(98)90267-7
37 https://doi.org/10.1046/j.1471-4159.1994.62041530.x
38 https://doi.org/10.1046/j.1471-4159.1999.721759.x
39 https://doi.org/10.1073/pnas.012606199
40 https://doi.org/10.1073/pnas.92.16.7297
41 https://doi.org/10.1074/jbc.273.47.31160
42 https://doi.org/10.1074/jbc.m211495200
43 https://doi.org/10.1111/j.1432-1033.1997.t01-3-00001.x
44 https://doi.org/10.1111/j.1471-4159.1987.tb01021.x
45 https://doi.org/10.1126/science.280.5368.1371
46 https://doi.org/10.1126/science.288.5475.2379
47 https://doi.org/10.1126/science.289.5487.2122
48 https://doi.org/10.1172/jci108764
49 https://doi.org/10.1172/jci12954
50 https://doi.org/10.2337/diab.46.3.393
51 https://doi.org/10.2337/diabetes.46.3.393
52 https://doi.org/10.2337/diabetes.50.4.733
53 https://doi.org/10.2337/diabetes.51.2.271
54 https://doi.org/10.3181/00379727-136-35478
55 schema:datePublished 2003-06
56 schema:datePublishedReg 2003-06-01
57 schema:description The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty acid (LCFA) entry into mitochondria, where the LCFAs undergo beta-oxidation. To investigate the mechanism(s) by which central metabolism of lipids can modulate energy balance, we selectively reduced lipid oxidation in the hypothalamus. We decreased the activity of CPT1 by administering to rats a ribozyme-containing plasmid designed specifically to decrease the expression of this enzyme or by infusing pharmacological inhibitors of its activity into the third cerebral ventricle. Either genetic or biochemical inhibition of hypothalamic CPT1 activity was sufficient to substantially diminish food intake and endogenous glucose production. These results indicated that changes in the rate of lipid oxidation in selective hypothalamic neurons signaled nutrient availability to the hypothalamus, which in turn modulated the exogenous and endogenous inputs of nutrients into the circulation.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N0b2cdfadd1844cab86bea4f2a50cf34b
62 Nff4534b225f4441aa139cd4c88eeb946
63 sg:journal.1113716
64 schema:name Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
65 schema:pagination 756
66 schema:productId N058e278fd4b34c27985cfcc6ffb1e576
67 N41b597ef9a1e42a8a214b93f8d6d7f47
68 N7827789ee6054b99a07d328d7c9224fa
69 Na5f65e70895749a99a628da12a643383
70 Na890cc74d2984a11bf470905bc8e10d1
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003936654
72 https://doi.org/10.1038/nm873
73 schema:sdDatePublished 2019-04-11T12:24
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N369c9d5cc4114670b6f40de5437efaa8
76 schema:url https://www.nature.com/articles/nm873
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N01d2880c3e60422289b93d9a88f32b9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Rats
82 rdf:type schema:DefinedTerm
83 N02b57e2ee73d49498741b72909f0698d rdf:first sg:person.01347734253.62
84 rdf:rest Nd3109997fca142aa8e21c2ed817767e2
85 N058e278fd4b34c27985cfcc6ffb1e576 schema:name pubmed_id
86 schema:value 12754501
87 rdf:type schema:PropertyValue
88 N05904c3444b2489e8617efbacca5a8c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Hypothalamus
90 rdf:type schema:DefinedTerm
91 N0b2cdfadd1844cab86bea4f2a50cf34b schema:volumeNumber 9
92 rdf:type schema:PublicationVolume
93 N118d914593e748409ae6c5ac03be16f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Neuropeptide Y
95 rdf:type schema:DefinedTerm
96 N1638b34293f44062aba17cf667a7483c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Intercellular Signaling Peptides and Proteins
98 rdf:type schema:DefinedTerm
99 N184b9eff04404b42841765d3ecb3d56d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Oxidation-Reduction
101 rdf:type schema:DefinedTerm
102 N1a48da3e72584108a7b803544c0cf523 schema:name Department of Metabolism & Endocrinology, Sigma Tau Pharmaceutical Industries, Via Pontina km 30,400, 00040 Pomezia, Italy.
103 rdf:type schema:Organization
104 N26258d20fde5464da823268c27fed967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Proteins
106 rdf:type schema:DefinedTerm
107 N369c9d5cc4114670b6f40de5437efaa8 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N41b597ef9a1e42a8a214b93f8d6d7f47 schema:name doi
110 schema:value 10.1038/nm873
111 rdf:type schema:PropertyValue
112 N523cd27694f841d4843b547dfa04e1c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Eating
114 rdf:type schema:DefinedTerm
115 N5ef849be6cc247c4a63710ede872ad4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Insulin
117 rdf:type schema:DefinedTerm
118 N7827789ee6054b99a07d328d7c9224fa schema:name nlm_unique_id
119 schema:value 9502015
120 rdf:type schema:PropertyValue
121 N8467d703982a4ca881cc6671ed80cfb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Liver
123 rdf:type schema:DefinedTerm
124 N8b5caee5aee84f6ea2cd24b2f537a6b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Carnitine O-Palmitoyltransferase
126 rdf:type schema:DefinedTerm
127 N8e69cc1f43a04b19bf3691aacc248fb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Glucose
129 rdf:type schema:DefinedTerm
130 N8f4517d65604437586a0d2d54b5cb0bd rdf:first sg:person.0726655573.63
131 rdf:rest rdf:nil
132 N9985ab7badfd4533b7909ef8f5b8c42a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Nucleic Acid Conformation
134 rdf:type schema:DefinedTerm
135 N9cd76864d6b84a20bcb5ee773c43bf88 rdf:first sg:person.01231252217.30
136 rdf:rest N8f4517d65604437586a0d2d54b5cb0bd
137 N9d49897a0de84425974be72dc467a9bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Agouti-Related Protein
139 rdf:type schema:DefinedTerm
140 Na0171d0c6fca40639862aa71895e8fcc rdf:first sg:person.01301621053.96
141 rdf:rest N02b57e2ee73d49498741b72909f0698d
142 Na5f65e70895749a99a628da12a643383 schema:name readcube_id
143 schema:value 12c18a66108ddcdc7c635be4b87daa202aa9a6c842b50f6daeba186f1ac0a758
144 rdf:type schema:PropertyValue
145 Na890cc74d2984a11bf470905bc8e10d1 schema:name dimensions_id
146 schema:value pub.1003936654
147 rdf:type schema:PropertyValue
148 Nb6ad48da3cb640ca9d996facd7420b77 schema:name Department of Metabolism & Endocrinology, Sigma Tau Pharmaceutical Industries, Via Pontina km 30,400, 00040 Pomezia, Italy.
149 rdf:type schema:Organization
150 Nd086f4f4787a42cca79f2dcc553ea263 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Male
152 rdf:type schema:DefinedTerm
153 Nd099d3f52cff4c8584abf97415141357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Base Sequence
155 rdf:type schema:DefinedTerm
156 Nd0f86c94aa0e42a79faaed86882739f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Fatty Acids
158 rdf:type schema:DefinedTerm
159 Nd3109997fca142aa8e21c2ed817767e2 rdf:first sg:person.01176452124.36
160 rdf:rest N9cd76864d6b84a20bcb5ee773c43bf88
161 Ne2d7713aac604ea3843ebcff451fa5f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name RNA, Catalytic
163 rdf:type schema:DefinedTerm
164 Ne7ee05d5da324abda5654d0ee4b84290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 Nf7158827ea54450b8e2330bab5020e50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Rats, Sprague-Dawley
169 rdf:type schema:DefinedTerm
170 Nff4534b225f4441aa139cd4c88eeb946 schema:issueNumber 6
171 rdf:type schema:PublicationIssue
172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biological Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biochemistry and Cell Biology
177 rdf:type schema:DefinedTerm
178 sg:grant.2494679 http://pending.schema.org/fundedItem sg:pub.10.1038/nm873
179 rdf:type schema:MonetaryGrant
180 sg:grant.2495274 http://pending.schema.org/fundedItem sg:pub.10.1038/nm873
181 rdf:type schema:MonetaryGrant
182 sg:grant.2627710 http://pending.schema.org/fundedItem sg:pub.10.1038/nm873
183 rdf:type schema:MonetaryGrant
184 sg:grant.2634820 http://pending.schema.org/fundedItem sg:pub.10.1038/nm873
185 rdf:type schema:MonetaryGrant
186 sg:journal.1113716 schema:issn 1078-8956
187 1546-170X
188 schema:name Nature Medicine
189 rdf:type schema:Periodical
190 sg:person.01176452124.36 schema:affiliation Nb6ad48da3cb640ca9d996facd7420b77
191 schema:familyName Arduini
192 schema:givenName Arduino
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176452124.36
194 rdf:type schema:Person
195 sg:person.01231252217.30 schema:affiliation N1a48da3e72584108a7b803544c0cf523
196 schema:familyName Conti
197 schema:givenName Roberto
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231252217.30
199 rdf:type schema:Person
200 sg:person.01301621053.96 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
201 schema:familyName Obici
202 schema:givenName Silvana
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301621053.96
204 rdf:type schema:Person
205 sg:person.01347734253.62 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
206 schema:familyName Feng
207 schema:givenName Zhaohui
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347734253.62
209 rdf:type schema:Person
210 sg:person.0726655573.63 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
211 schema:familyName Rossetti
212 schema:givenName Luciano
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726655573.63
214 rdf:type schema:Person
215 sg:pub.10.1038/282503a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046852793
216 https://doi.org/10.1038/282503a0
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/31474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002281544
219 https://doi.org/10.1038/31474
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/35007504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037649840
222 https://doi.org/10.1038/35007504
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/35007534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036745532
225 https://doi.org/10.1038/35007534
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/35071088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014015421
228 https://doi.org/10.1038/35071088
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/382250a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019931158
231 https://doi.org/10.1038/382250a0
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nm0202-179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038993554
234 https://doi.org/10.1038/nm0202-179
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nn0602-861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022530334
237 https://doi.org/10.1038/nn0602-861
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/sj.gt.3300635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047202492
240 https://doi.org/10.1038/sj.gt.3300635
241 rdf:type schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1077646274 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082811458 schema:CreativeWork
244 https://doi.org/10.1016/0003-2697(85)90434-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041290814
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0006-8993(73)90290-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038960030
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0140-6736(98)90267-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004764018
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1046/j.1471-4159.1994.62041530.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022478936
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1046/j.1471-4159.1999.721759.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029779978
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.012606199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000982773
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.92.16.7297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018266629
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1074/jbc.273.47.31160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039744733
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1074/jbc.m211495200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027858626
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1432-1033.1997.t01-3-00001.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765359
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1471-4159.1987.tb01021.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014705606
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1126/science.280.5368.1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561249
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/science.288.5475.2379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570085
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1126/science.289.5487.2122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571004
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1172/jci108764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017952828
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1172/jci12954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416086
275 rdf:type schema:CreativeWork
276 https://doi.org/10.2337/diab.46.3.393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738131
277 rdf:type schema:CreativeWork
278 https://doi.org/10.2337/diabetes.46.3.393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070743513
279 rdf:type schema:CreativeWork
280 https://doi.org/10.2337/diabetes.50.4.733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047208344
281 rdf:type schema:CreativeWork
282 https://doi.org/10.2337/diabetes.51.2.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004441756
283 rdf:type schema:CreativeWork
284 https://doi.org/10.3181/00379727-136-35478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049021715
285 rdf:type schema:CreativeWork
286 https://www.grid.ac/institutes/grid.251993.5 schema:alternateName Albert Einstein College of Medicine
287 schema:name Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...