Ontology type: schema:ScholarlyArticle
2002-06-24
AUTHORSHaidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis, Lieping Chen
ABSTRACTB7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of tumor cell lines. Cancer cell–associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-1+ tumors in vivo. These findings have implications for the design of T cell–based cancer immunotherapy. More... »
PAGES793-800
http://scigraph.springernature.com/pub.10.1038/nm730
DOIhttp://dx.doi.org/10.1038/nm730
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1043110107
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12091876
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antigens, CD",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antigens, Surface",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis Regulatory Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B7-1 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B7-H1 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Separation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fas Ligand Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Flow Cytometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Activation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Melanoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred Strains",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peptides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Programmed Cell Death 1 Receptor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recombinant Fusion Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Lymphocytes, Cytotoxic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "TNF-Related Apoptosis-Inducing Ligand",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Cells, Cultured",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Escape",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Necrosis Factor-alpha",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Dong",
"givenName": "Haidong",
"id": "sg:person.0641174237.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641174237.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Strome",
"givenName": "Scott E.",
"id": "sg:person.01362243375.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362243375.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Salomao",
"givenName": "Diva R.",
"id": "sg:person.01117612001.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117612001.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Tamura",
"givenName": "Hideto",
"id": "sg:person.014473672754.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014473672754.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Hirano",
"givenName": "Fumiya",
"id": "sg:person.01011641736.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011641736.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Flies",
"givenName": "Dallas B.",
"id": "sg:person.01057755136.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057755136.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Roche",
"givenName": "Patrick C.",
"id": "sg:person.012074526072.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012074526072.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Lu",
"givenName": "Jun",
"id": "sg:person.0662003705.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662003705.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Zhu",
"givenName": "Gefeng",
"id": "sg:person.01274747456.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274747456.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Tamada",
"givenName": "Koji",
"id": "sg:person.01310432136.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310432136.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA",
"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Lennon",
"givenName": "Vanda A.",
"id": "sg:person.0575723637.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575723637.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Celis",
"givenName": "Esteban",
"id": "sg:person.01244260402.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244260402.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Lieping",
"id": "sg:person.016303325577.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016303325577.21"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1385/1-59259-079-9:247",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005835347",
"https://doi.org/10.1385/1-59259-079-9:247"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/86297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022248670",
"https://doi.org/10.1038/86297"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/6477",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052580067",
"https://doi.org/10.1038/6477"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/11383",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016885432",
"https://doi.org/10.1038/11383"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/70932",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005008226",
"https://doi.org/10.1038/70932"
],
"type": "CreativeWork"
}
],
"datePublished": "2002-06-24",
"datePublishedReg": "2002-06-24",
"description": "B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-\u03b3 upregulates B7-H1 on the surface of tumor cell lines. Cancer cell\u2013associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-1+ tumors in vivo. These findings have implications for the design of T cell\u2013based cancer immunotherapy.",
"genre": "article",
"id": "sg:pub.10.1038/nm730",
"inLanguage": "en",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2474115",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2473997",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2474832",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2438813",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2474421",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2467914",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1113716",
"issn": [
"1078-8956",
"1546-170X"
],
"name": "Nature Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"keywords": [
"B7-H1",
"tumor-associated B7-H1",
"pro-inflammatory cytokine interferon",
"cell-based cancer immunotherapy",
"PD-1 receptor",
"humoral immune response",
"normal human tissues",
"PD-1",
"P815 tumor",
"costimulatory molecules",
"cancer immunotherapy",
"B7 family",
"cytokine interferon",
"B7-1",
"immune response",
"immune evasion",
"tumor cell lines",
"cell clones",
"macrophage lineage",
"more receptors",
"human carcinomas",
"cell apoptosis",
"potential mechanisms",
"apoptotic effects",
"cell lines",
"tumors",
"apoptosis",
"receptors",
"human tissues",
"cells",
"immunotherapy",
"carcinoma",
"lung",
"interferon",
"colon",
"melanoma",
"vitro",
"vivo",
"tissue",
"evasion",
"expression",
"findings",
"response",
"regulation",
"clones",
"contrast",
"effect",
"mechanism",
"family",
"addition",
"members",
"lineages",
"lines",
"implications",
"growth",
"molecules",
"design",
"surface"
],
"name": "Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion",
"pagination": "793-800",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1043110107"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nm730"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12091876"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nm730",
"https://app.dimensions.ai/details/publication/pub.1043110107"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:50",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_361.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nm730"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm730'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm730'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm730'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm730'
This table displays all metadata directly associated to this object as RDF triples.
362 TRIPLES
22 PREDICATES
119 URIs
106 LITERALS
37 BLANK NODES