Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12

AUTHORS

Pisana Moroni Rawson, Caroline Molette, Melissa Videtta, Laura Altieri, Debora Franceschini, Tiziana Donato, Luigi Finocchi, Antonella Propato, Marino Paroli, Francesca Meloni, Claudio M Mastroianni, Gabriella d'Ettorre, John Sidney, Alessandro Sette, Vincenzo Barnaba

ABSTRACT

We found that the proteome of apoptotic T cells includes prominent fragments of cellular proteins generated by caspases and that a high proportion of distinct T cell epitopes in these fragments is recognized by CD8+ T cells during HIV infection. The frequencies of effector CD8+ T cells that are specific for apoptosis-dependent epitopes correlate with the frequency of circulating apoptotic CD4+ T cells in HIV-1-infected individuals. We propose that these self-reactive effector CD8+ T cells may contribute to the systemic immune activation during chronic HIV infection. The caspase-dependent cleavage of proteins associated with apoptotic cells has a key role in the induction of self-reactive CD8+ T cell responses, as the caspase-cleaved fragments are efficiently targeted to the processing machinery and are cross-presented by dendritic cells. These findings demonstrate a previously undescribed role for caspases in immunopathology. More... »

PAGES

1431-1439

References to SciGraph publications

  • 2004-02. Role of the cytoskeleton during leukocyte responses in NATURE REVIEWS IMMUNOLOGY
  • 2004-09. The abc's (and xyz's) of peptide sequencing in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2003-10. Molecular identification of a danger signal that alerts the immune system to dying cells in NATURE
  • 2005-06. Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells in NATURE IMMUNOLOGY
  • 2006-03. HIV disease: fallout from a mucosal catastrophe? in NATURE IMMUNOLOGY
  • 2002-01. The enemy within: keeping self-reactive T cells at bay in the periphery in NATURE REVIEWS IMMUNOLOGY
  • 1990-05. Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes in NATURE
  • 2006-03. Pathogenesis of HIV infection: what the virus spares is as important as what it destroys in NATURE MEDICINE
  • 2002-02. Epitope spreading in immune-mediated diseases: implications for immunotherapy in NATURE REVIEWS IMMUNOLOGY
  • 2006-12. Microbial translocation is a cause of systemic immune activation in chronic HIV infection in NATURE MEDICINE
  • 2005-03. Cross-presentation by intercellular peptide transfer through gap junctions in NATURE
  • 2004-08. Helping the CD8+ T-cell response in NATURE REVIEWS IMMUNOLOGY
  • 2001-07. Apoptotic cells overexpress vinculin and induce vinculin-specific cytotoxic T-cell cross-priming in NATURE MEDICINE
  • 1970-08. Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm1679

    DOI

    http://dx.doi.org/10.1038/nm1679

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032222044

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18026114


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigen Presentation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD8-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caspases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytoskeleton", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epitopes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HIV Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vimentin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sapienza University of Rome", 
              "id": "https://www.grid.ac/institutes/grid.7841.a", 
              "name": [
                "Fondazione Andrea Cesalpino-Dipartimento di Medicina Interna, Sapienza Universit\u00e0 di Roma, 00161 Rome, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rawson", 
            "givenName": "Pisana Moroni", 
            "id": "sg:person.0652236717.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652236717.14"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Molette", 
            "givenName": "Caroline", 
            "id": "sg:person.01215371552.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215371552.00"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Videtta", 
            "givenName": "Melissa", 
            "id": "sg:person.0612016000.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612016000.87"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Altieri", 
            "givenName": "Laura", 
            "id": "sg:person.0740472751.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740472751.47"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Franceschini", 
            "givenName": "Debora", 
            "id": "sg:person.01221173500.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221173500.73"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Donato", 
            "givenName": "Tiziana", 
            "id": "sg:person.01054721351.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054721351.73"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Finocchi", 
            "givenName": "Luigi", 
            "id": "sg:person.01216215735.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216215735.11"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Propato", 
            "givenName": "Antonella", 
            "id": "sg:person.0644171460.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644171460.44"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Paroli", 
            "givenName": "Marino", 
            "id": "sg:person.01237263151.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237263151.77"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Meloni", 
            "givenName": "Francesca", 
            "id": "sg:person.01331464063.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331464063.76"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Mastroianni", 
            "givenName": "Claudio M", 
            "id": "sg:person.01130421036.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130421036.07"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "d'Ettorre", 
            "givenName": "Gabriella", 
            "id": "sg:person.0657532603.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657532603.19"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sidney", 
            "givenName": "John", 
            "id": "sg:person.01027013077.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027013077.15"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sette", 
            "givenName": "Alessandro", 
            "id": "sg:person.016527313277.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016527313277.78"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Barnaba", 
            "givenName": "Vincenzo", 
            "id": "sg:person.0713111670.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713111670.45"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0308345101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004060983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004971191", 
              "https://doi.org/10.1038/ni1316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004971191", 
              "https://doi.org/10.1038/ni1316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006562851", 
              "https://doi.org/10.1038/nature01991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006562851", 
              "https://doi.org/10.1038/nature01991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00449-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008090278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008522146", 
              "https://doi.org/10.1038/ni1201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008522146", 
              "https://doi.org/10.1038/ni1201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.19.1.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008840820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009865103", 
              "https://doi.org/10.1038/nm1380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009865103", 
              "https://doi.org/10.1038/nm1380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/227680a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010419937", 
              "https://doi.org/10.1038/227680a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1096378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012883640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(03)00051-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013419547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m402638200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013652290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018339527", 
              "https://doi.org/10.1038/nri1268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018339527", 
              "https://doi.org/10.1038/nri1268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.143.5.1283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018932677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019284442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20031550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019450229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020064545", 
              "https://doi.org/10.1038/89930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020064545", 
              "https://doi.org/10.1038/89930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020255566", 
              "https://doi.org/10.1038/nri701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020255566", 
              "https://doi.org/10.1038/nri701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bms.1200220605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021130881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bms.1200220605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021130881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mas.10079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022695672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023517203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024193691", 
              "https://doi.org/10.1038/nature03290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024193691", 
              "https://doi.org/10.1038/nature03290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025529346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026493537", 
              "https://doi.org/10.1038/nm1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026493537", 
              "https://doi.org/10.1038/nm1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.15.1.821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028792867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029121021", 
              "https://doi.org/10.1038/nri724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029121021", 
              "https://doi.org/10.1038/nri724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.bor.0000171215.87993.6b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031965302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.bor.0000171215.87993.6b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031965302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.bor.0000171215.87993.6b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031965302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci19799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032283694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.179.4.1109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032628043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032981906", 
              "https://doi.org/10.1038/nri1413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032981906", 
              "https://doi.org/10.1038/nri1413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2005.09.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033492330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.7.1359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034759960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.43.28057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035775190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20051106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037133565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2006.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038192405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1071059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038790461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0198-8859(01)00319-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041238791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0030185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041777978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20050915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041968746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200324539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043476937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/345258a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043946283", 
              "https://doi.org/10.1038/345258a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20051379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045368793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049058911", 
              "https://doi.org/10.1038/nrm1468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049058911", 
              "https://doi.org/10.1038/nrm1468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1096268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062449506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074469636", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.3.1241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075090476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.7.4407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077025413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.2.796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077077130"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2007-12", 
        "datePublishedReg": "2007-12-01", 
        "description": "We found that the proteome of apoptotic T cells includes prominent fragments of cellular proteins generated by caspases and that a high proportion of distinct T cell epitopes in these fragments is recognized by CD8+ T cells during HIV infection. The frequencies of effector CD8+ T cells that are specific for apoptosis-dependent epitopes correlate with the frequency of circulating apoptotic CD4+ T cells in HIV-1-infected individuals. We propose that these self-reactive effector CD8+ T cells may contribute to the systemic immune activation during chronic HIV infection. The caspase-dependent cleavage of proteins associated with apoptotic cells has a key role in the induction of self-reactive CD8+ T cell responses, as the caspase-cleaved fragments are efficiently targeted to the processing machinery and are cross-presented by dendritic cells. These findings demonstrate a previously undescribed role for caspases in immunopathology.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm1679", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "name": "Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection", 
        "pagination": "1431-1439", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "997fdc6879136d499b4aff915335483f125a1bded99cd077ba243af15e4a56c6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18026114"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm1679"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032222044"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm1679", 
          "https://app.dimensions.ai/details/publication/pub.1032222044"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nm/journal/v13/n12/full/nm1679.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm1679'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm1679'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1679'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm1679'


     

    This table displays all metadata directly associated to this object as RDF triples.

    367 TRIPLES      21 PREDICATES      91 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm1679 schema:about N13bc32b4e9144503baca80a83130b2c7
    2 N2ff02ca2c1844b2eaabb502728a3efb7
    3 N533c04f39e9a4f60becc150b7750b609
    4 N5772befd501d4abe96929da87228bdbd
    5 N5df109990211433d95ff16a8e574b1f2
    6 N81dff1822ea349f7b8339d59c91414ca
    7 N84e606ff44794565ae2d720ee7676d07
    8 N8e02dc5d62c04e64949c02c0172614d2
    9 N97e82696bfb24165af17195ddfd8e5b2
    10 N9dc3840034ee41379e1e9060c98eacaa
    11 Nb306d895a6b74e62ab201cb53f4a6812
    12 Nb877aa28db6c40a69d1c752045c0bbde
    13 Nb8cd89b91d634e508201830735d90d3f
    14 Ne8f6d79f8c264b588742336d86f649fc
    15 Nf7da6b30708a4eb2b3be9fe75f0c72b3
    16 anzsrc-for:11
    17 anzsrc-for:1107
    18 schema:author Nbabf6ae80ebb4250b39f8bb09fa14586
    19 schema:citation sg:pub.10.1038/227680a0
    20 sg:pub.10.1038/345258a0
    21 sg:pub.10.1038/89930
    22 sg:pub.10.1038/nature01991
    23 sg:pub.10.1038/nature03290
    24 sg:pub.10.1038/ni1201
    25 sg:pub.10.1038/ni1316
    26 sg:pub.10.1038/nm1380
    27 sg:pub.10.1038/nm1511
    28 sg:pub.10.1038/nri1268
    29 sg:pub.10.1038/nri1413
    30 sg:pub.10.1038/nri701
    31 sg:pub.10.1038/nri724
    32 sg:pub.10.1038/nrm1468
    33 https://app.dimensions.ai/details/publication/pub.1074469636
    34 https://doi.org/10.1002/bms.1200220605
    35 https://doi.org/10.1002/eji.200324539
    36 https://doi.org/10.1002/mas.10079
    37 https://doi.org/10.1016/0003-2697(76)90527-3
    38 https://doi.org/10.1016/j.coi.2005.09.018
    39 https://doi.org/10.1016/j.it.2006.09.006
    40 https://doi.org/10.1016/s0092-8674(01)00449-4
    41 https://doi.org/10.1016/s0198-8859(01)00319-6
    42 https://doi.org/10.1016/s1074-7613(03)00051-7
    43 https://doi.org/10.1073/pnas.0308345101
    44 https://doi.org/10.1074/jbc.273.43.28057
    45 https://doi.org/10.1074/jbc.m402638200
    46 https://doi.org/10.1084/jem.143.5.1283
    47 https://doi.org/10.1084/jem.179.4.1109
    48 https://doi.org/10.1084/jem.188.7.1359
    49 https://doi.org/10.1084/jem.20031550
    50 https://doi.org/10.1084/jem.20050915
    51 https://doi.org/10.1084/jem.20051106
    52 https://doi.org/10.1084/jem.20051379
    53 https://doi.org/10.1097/01.bor.0000171215.87993.6b
    54 https://doi.org/10.1126/science.1071059
    55 https://doi.org/10.1126/science.1096268
    56 https://doi.org/10.1126/science.1096378
    57 https://doi.org/10.1146/annurev.immunol.15.1.821
    58 https://doi.org/10.1146/annurev.immunol.19.1.47
    59 https://doi.org/10.1146/annurev.immunol.21.120601.141040
    60 https://doi.org/10.1146/annurev.immunol.21.120601.141053
    61 https://doi.org/10.1172/jci19799
    62 https://doi.org/10.1371/journal.pbio.0030185
    63 https://doi.org/10.4049/jimmunol.169.3.1241
    64 https://doi.org/10.4049/jimmunol.174.7.4407
    65 https://doi.org/10.4049/jimmunol.175.2.796
    66 schema:datePublished 2007-12
    67 schema:datePublishedReg 2007-12-01
    68 schema:description We found that the proteome of apoptotic T cells includes prominent fragments of cellular proteins generated by caspases and that a high proportion of distinct T cell epitopes in these fragments is recognized by CD8+ T cells during HIV infection. The frequencies of effector CD8+ T cells that are specific for apoptosis-dependent epitopes correlate with the frequency of circulating apoptotic CD4+ T cells in HIV-1-infected individuals. We propose that these self-reactive effector CD8+ T cells may contribute to the systemic immune activation during chronic HIV infection. The caspase-dependent cleavage of proteins associated with apoptotic cells has a key role in the induction of self-reactive CD8+ T cell responses, as the caspase-cleaved fragments are efficiently targeted to the processing machinery and are cross-presented by dendritic cells. These findings demonstrate a previously undescribed role for caspases in immunopathology.
    69 schema:genre research_article
    70 schema:inLanguage en
    71 schema:isAccessibleForFree false
    72 schema:isPartOf N192030f5571d4253a0c00a2102cb7a40
    73 Ndfeb8ebccd6f4db0a48a676e40949deb
    74 sg:journal.1113716
    75 schema:name Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection
    76 schema:pagination 1431-1439
    77 schema:productId N4cd338ea3a354343995b9b21c6db59f2
    78 N90b2196942ff43ca8cb9a85c1a239fa8
    79 Na70a7d91441548dd94888d089b910fa9
    80 Nb048b49145ef40499c337ab8714736a8
    81 Nc2ac281def3441c697c488e50aa26248
    82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032222044
    83 https://doi.org/10.1038/nm1679
    84 schema:sdDatePublished 2019-04-10T19:45
    85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    86 schema:sdPublisher N7e044842dc6043be81975ee2f4e16bf3
    87 schema:url http://www.nature.com/nm/journal/v13/n12/full/nm1679.html
    88 sgo:license sg:explorer/license/
    89 sgo:sdDataset articles
    90 rdf:type schema:ScholarlyArticle
    91 N00d90e21879e4c05a3268145793b5d1a rdf:first sg:person.0657532603.19
    92 rdf:rest N741b4ed6cad943a48d6f2b9b15926a6b
    93 N038b9d99f31040e28c5137b462cee00b rdf:first sg:person.01237263151.77
    94 rdf:rest N46b14449f01a4f1b88f076d814d4cc3a
    95 N0dc787eb882f41678f40e7fed6917283 rdf:first sg:person.0740472751.47
    96 rdf:rest N77f169344b5148be963f40701c54fdd3
    97 N13bc32b4e9144503baca80a83130b2c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name CD4-Positive T-Lymphocytes
    99 rdf:type schema:DefinedTerm
    100 N192030f5571d4253a0c00a2102cb7a40 schema:volumeNumber 13
    101 rdf:type schema:PublicationVolume
    102 N2ff02ca2c1844b2eaabb502728a3efb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Antigen Presentation
    104 rdf:type schema:DefinedTerm
    105 N3575382267a6477b84396f1ecb37b9a7 rdf:first sg:person.01054721351.73
    106 rdf:rest Nf64fa882b32e427da509504a911dfc34
    107 N46b14449f01a4f1b88f076d814d4cc3a rdf:first sg:person.01331464063.76
    108 rdf:rest N4b08c473a4664df49d396a8c8a184a81
    109 N4b08c473a4664df49d396a8c8a184a81 rdf:first sg:person.01130421036.07
    110 rdf:rest N00d90e21879e4c05a3268145793b5d1a
    111 N4cd338ea3a354343995b9b21c6db59f2 schema:name readcube_id
    112 schema:value 997fdc6879136d499b4aff915335483f125a1bded99cd077ba243af15e4a56c6
    113 rdf:type schema:PropertyValue
    114 N533c04f39e9a4f60becc150b7750b609 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name CD8-Positive T-Lymphocytes
    116 rdf:type schema:DefinedTerm
    117 N5772befd501d4abe96929da87228bdbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Dendritic Cells
    119 rdf:type schema:DefinedTerm
    120 N5df109990211433d95ff16a8e574b1f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Middle Aged
    122 rdf:type schema:DefinedTerm
    123 N741b4ed6cad943a48d6f2b9b15926a6b rdf:first sg:person.01027013077.15
    124 rdf:rest Nb6a563e8a2094a72ac4b7464d98500ff
    125 N7791157a324e4415bbd0ec753ef75332 rdf:first sg:person.01215371552.00
    126 rdf:rest Nbf27433de3034af5bcbb820914abe71f
    127 N77f169344b5148be963f40701c54fdd3 rdf:first sg:person.01221173500.73
    128 rdf:rest N3575382267a6477b84396f1ecb37b9a7
    129 N7e044842dc6043be81975ee2f4e16bf3 schema:name Springer Nature - SN SciGraph project
    130 rdf:type schema:Organization
    131 N81dff1822ea349f7b8339d59c91414ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Caspases
    133 rdf:type schema:DefinedTerm
    134 N84e606ff44794565ae2d720ee7676d07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Vimentin
    136 rdf:type schema:DefinedTerm
    137 N8e02dc5d62c04e64949c02c0172614d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Female
    139 rdf:type schema:DefinedTerm
    140 N90b2196942ff43ca8cb9a85c1a239fa8 schema:name nlm_unique_id
    141 schema:value 9502015
    142 rdf:type schema:PropertyValue
    143 N97d62aba8f544e13be9f2a0cbfd9244e rdf:first sg:person.0713111670.45
    144 rdf:rest rdf:nil
    145 N97e82696bfb24165af17195ddfd8e5b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Adult
    147 rdf:type schema:DefinedTerm
    148 N9dc3840034ee41379e1e9060c98eacaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name HIV Infections
    150 rdf:type schema:DefinedTerm
    151 Na70a7d91441548dd94888d089b910fa9 schema:name pubmed_id
    152 schema:value 18026114
    153 rdf:type schema:PropertyValue
    154 Nb048b49145ef40499c337ab8714736a8 schema:name doi
    155 schema:value 10.1038/nm1679
    156 rdf:type schema:PropertyValue
    157 Nb306d895a6b74e62ab201cb53f4a6812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Apoptosis
    159 rdf:type schema:DefinedTerm
    160 Nb6a563e8a2094a72ac4b7464d98500ff rdf:first sg:person.016527313277.78
    161 rdf:rest N97d62aba8f544e13be9f2a0cbfd9244e
    162 Nb877aa28db6c40a69d1c752045c0bbde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Epitopes
    164 rdf:type schema:DefinedTerm
    165 Nb8cd89b91d634e508201830735d90d3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Cytoskeleton
    167 rdf:type schema:DefinedTerm
    168 Nbabf6ae80ebb4250b39f8bb09fa14586 rdf:first sg:person.0652236717.14
    169 rdf:rest N7791157a324e4415bbd0ec753ef75332
    170 Nbc4fb0da99504932af922c2df430c6c6 rdf:first sg:person.0644171460.44
    171 rdf:rest N038b9d99f31040e28c5137b462cee00b
    172 Nbf27433de3034af5bcbb820914abe71f rdf:first sg:person.0612016000.87
    173 rdf:rest N0dc787eb882f41678f40e7fed6917283
    174 Nc2ac281def3441c697c488e50aa26248 schema:name dimensions_id
    175 schema:value pub.1032222044
    176 rdf:type schema:PropertyValue
    177 Ndfeb8ebccd6f4db0a48a676e40949deb schema:issueNumber 12
    178 rdf:type schema:PublicationIssue
    179 Ne8f6d79f8c264b588742336d86f649fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Male
    181 rdf:type schema:DefinedTerm
    182 Nf64fa882b32e427da509504a911dfc34 rdf:first sg:person.01216215735.11
    183 rdf:rest Nbc4fb0da99504932af922c2df430c6c6
    184 Nf7da6b30708a4eb2b3be9fe75f0c72b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Humans
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Medical and Health Sciences
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Immunology
    192 rdf:type schema:DefinedTerm
    193 sg:journal.1113716 schema:issn 1078-8956
    194 1546-170X
    195 schema:name Nature Medicine
    196 rdf:type schema:Periodical
    197 sg:person.01027013077.15 schema:familyName Sidney
    198 schema:givenName John
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027013077.15
    200 rdf:type schema:Person
    201 sg:person.01054721351.73 schema:familyName Donato
    202 schema:givenName Tiziana
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054721351.73
    204 rdf:type schema:Person
    205 sg:person.01130421036.07 schema:familyName Mastroianni
    206 schema:givenName Claudio M
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130421036.07
    208 rdf:type schema:Person
    209 sg:person.01215371552.00 schema:familyName Molette
    210 schema:givenName Caroline
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215371552.00
    212 rdf:type schema:Person
    213 sg:person.01216215735.11 schema:familyName Finocchi
    214 schema:givenName Luigi
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216215735.11
    216 rdf:type schema:Person
    217 sg:person.01221173500.73 schema:familyName Franceschini
    218 schema:givenName Debora
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221173500.73
    220 rdf:type schema:Person
    221 sg:person.01237263151.77 schema:familyName Paroli
    222 schema:givenName Marino
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237263151.77
    224 rdf:type schema:Person
    225 sg:person.01331464063.76 schema:familyName Meloni
    226 schema:givenName Francesca
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331464063.76
    228 rdf:type schema:Person
    229 sg:person.016527313277.78 schema:familyName Sette
    230 schema:givenName Alessandro
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016527313277.78
    232 rdf:type schema:Person
    233 sg:person.0612016000.87 schema:familyName Videtta
    234 schema:givenName Melissa
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612016000.87
    236 rdf:type schema:Person
    237 sg:person.0644171460.44 schema:familyName Propato
    238 schema:givenName Antonella
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644171460.44
    240 rdf:type schema:Person
    241 sg:person.0652236717.14 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
    242 schema:familyName Rawson
    243 schema:givenName Pisana Moroni
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652236717.14
    245 rdf:type schema:Person
    246 sg:person.0657532603.19 schema:familyName d'Ettorre
    247 schema:givenName Gabriella
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657532603.19
    249 rdf:type schema:Person
    250 sg:person.0713111670.45 schema:familyName Barnaba
    251 schema:givenName Vincenzo
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713111670.45
    253 rdf:type schema:Person
    254 sg:person.0740472751.47 schema:familyName Altieri
    255 schema:givenName Laura
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740472751.47
    257 rdf:type schema:Person
    258 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
    259 https://doi.org/10.1038/227680a0
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/345258a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043946283
    262 https://doi.org/10.1038/345258a0
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/89930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020064545
    265 https://doi.org/10.1038/89930
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nature01991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006562851
    268 https://doi.org/10.1038/nature01991
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nature03290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024193691
    271 https://doi.org/10.1038/nature03290
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/ni1201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008522146
    274 https://doi.org/10.1038/ni1201
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/ni1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004971191
    277 https://doi.org/10.1038/ni1316
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nm1380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009865103
    280 https://doi.org/10.1038/nm1380
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nm1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026493537
    283 https://doi.org/10.1038/nm1511
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nri1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018339527
    286 https://doi.org/10.1038/nri1268
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/nri1413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032981906
    289 https://doi.org/10.1038/nri1413
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nri701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020255566
    292 https://doi.org/10.1038/nri701
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nri724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029121021
    295 https://doi.org/10.1038/nri724
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nrm1468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049058911
    298 https://doi.org/10.1038/nrm1468
    299 rdf:type schema:CreativeWork
    300 https://app.dimensions.ai/details/publication/pub.1074469636 schema:CreativeWork
    301 https://doi.org/10.1002/bms.1200220605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021130881
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1002/eji.200324539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043476937
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/mas.10079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022695672
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.coi.2005.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033492330
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.it.2006.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038192405
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0092-8674(01)00449-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008090278
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0198-8859(01)00319-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041238791
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s1074-7613(03)00051-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013419547
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.0308345101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004060983
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1074/jbc.273.43.28057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035775190
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1074/jbc.m402638200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013652290
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1084/jem.143.5.1283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018932677
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1084/jem.179.4.1109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032628043
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1084/jem.188.7.1359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034759960
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1084/jem.20031550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019450229
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1084/jem.20050915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041968746
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1084/jem.20051106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037133565
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1084/jem.20051379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045368793
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1097/01.bor.0000171215.87993.6b schema:sameAs https://app.dimensions.ai/details/publication/pub.1031965302
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1126/science.1071059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038790461
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1126/science.1096268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449506
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.1096378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012883640
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1146/annurev.immunol.15.1.821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028792867
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1146/annurev.immunol.19.1.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008840820
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1146/annurev.immunol.21.120601.141040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019284442
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1146/annurev.immunol.21.120601.141053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023517203
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1172/jci19799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032283694
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1371/journal.pbio.0030185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041777978
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.4049/jimmunol.169.3.1241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075090476
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.4049/jimmunol.174.7.4407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077025413
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.4049/jimmunol.175.2.796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077077130
    364 rdf:type schema:CreativeWork
    365 https://www.grid.ac/institutes/grid.7841.a schema:alternateName Sapienza University of Rome
    366 schema:name Fondazione Andrea Cesalpino-Dipartimento di Medicina Interna, Sapienza Università di Roma, 00161 Rome, Italy.
    367 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...