Catching bird flu in a droplet View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Juergen Pipper, Masafumi Inoue, Lisa F-P Ng, Pavel Neuzil, Yi Zhang, Lukas Novak

ABSTRACT

It is assumed that a timely mass administration of antiviral drugs, backed by quarantines and social distancing, could contain a nascent influenza epidemic at its source, provided that the first clusters of cases were localized within a short time. However, effective routine surveillance may be impossible in countries lacking basic public health resources. For a global containment strategy to be successful, low-cost, easy-to-use handheld units that permit decentralized testing would be vital. Here we present a microfluidic platform that can detect the highly pathogenic avian influenza virus H5N1 in a throat swab sample by using magnetic forces to manipulate a free droplet containing superparamagnetic particles. In a sequential process, the viral RNA is isolated, purified, preconcentrated by 50,000% and subjected to ultrafast real-time RT-PCR. Compared to commercially available tests, the bioassay is equally sensitive and is 440% faster and 2,000-5,000% cheaper. More... »

PAGES

1259-1263

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1634

DOI

http://dx.doi.org/10.1038/nm1634

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021009102

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17891145


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