α1β1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

Curdin Conrad, Onur Boyman, Giulia Tonel, Adrian Tun-Kyi, Ute Laggner, Antonin de Fougerolles, Victor Kotelianski, Humphrey Gardner, Frank O Nestle

ABSTRACT

Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of alpha1beta1 integrin (VLA-1) with collagen prevented accumulation of epidermal T cells and immunopathology of psoriasis. Alpha1beta1 integrin, a major collagen-binding surface receptor, was exclusively expressed by epidermal but not dermal T cells. Alpha1beta1-positive T cells showed characteristic surface markers of effector memory cells and contained high levels of interferon-gamma but not interleukin-4. Blockade of alpha1beta1 inhibited migration of T cells into the epidermis in a clinically relevant xenotransplantation model. This was paralleled by a complete inhibition of psoriasis development, comparable to that caused by tumor necrosis factor-alpha blockers. These results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment focusing on T cell-extracellular matrix interactions. More... »

PAGES

836-842

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm1605

DOI

http://dx.doi.org/10.1038/nm1605

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036182073

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17603494


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm1605'

RDF/XML is a standard XML format for linked data.

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